2 ILUMIEN™ PCI Optimization System The real voyage of discovery consists of not in seeking new landscapes,but in having new eyes Marcel Proust
3 il·lu·mi·nate That which illuminates gives light; especially, adjective, noun ,verb (used with object)to supply or brighten with light; light up. (OCT)to make lucid or clear; throw light on (a subject). (FFR+OCT)to enlighten, as with knowledge. (FFR+OCT)That which illuminates gives light; especially,intellectual light or knowledge.
5 Optimize PCIWhat to treat (FFR) → How to treat (OCT)Knowing which lesion to treat and how to treat it is the key to optimizing interventional treatment strategies.
6 PCI Optimized by FFR and OCT FFR OCT FFR guides PCI by identifying culprit lesions responsible for ischemia, ensuring a fully functional revascularization. Compared to PCI guided with angiography alone, FFR-guided PCI greatly improves outcomes.1↓PCIOptimized byFFR and OCTFFR‘WHAT TO TREAT’IDENTIFY culprit lesionsfor full functionalrevascularizationOCT‘HOW TO TREAT’OPTIMIZE Stentimplantation withsuperior visualization↑The ultra high resolution of OCT makes it the ideal tool to visualize vasculature, optimize stent implantation, strut coverage, neointimal response and follow-up.²,³
7 One Platform. Light Years Ahead. Moving Forward.
8 Mobile Integration“The ease of use of an integrated system — with the flexibility and cost efficiency of a mobile unit”
10 Mobile Integration Fast Easy Flexible Wireless FFR setup in one or multiple labsMove between FFR and OCT modalities with one touchEasyQuick and easy movement between multiple labsEasy on-screen guide simplifies proceduresFlexibleIntegrated case storage and easy patient ID retrievalSoftware upgradeable
11 The first system combining FFR and OCT The Clear AdvantageFFR: FAME Study1 and Wireless TechnologyFAME Shows that FFR:Reduces rates of death, myocardial, infarction and repeat revascularizationIdentifies culprit lesions that can cause ischemia,Is cost saving and does not prolong procedure time.ILUMIEN has Wireless FFR.PressureWire™ Aeris™OCT: Original and Superior(to any existing imaging)ILUMIEN OCT resolution is 10 times better and 20 times faster than IVUS.4-8Optimize stents:Implantation, placement, strut coverage, neointimal response and follow-up.2,3Differentiate and classify plaque.9The first system combining FFR and OCT
12 The Clear AdvantageFirst to combine FFR and OCT in one convenient systemWireless (FFR) for easy set-upQuick, easy transition between roomsSole sponsor of the FAME trial with PressureWire AerisProvides physicians with more information to optimize PCI
14 REFERENCESTonino PA , De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360(3):Murata A, Wallace-Bradley D, Tellez A, et al. Accuracy of optical coherence tomography in the evaluation of neointimal coverage after stent implantation. JACC Cardiovasc Imaging. 2010;3:76-84.Santos MC, Lin T, and Barlis P. In-stent restenosis associated with stent malapposition: Seven year optical coherence tomography findings. Int J Cardiol. (2010), doi: /j.ijcardNissen SE, Yock P; Intravascular Ultrasound: Novel Pathophysiological Insights and Current Clinical Applications. Circulation 2001;103;Dijkstra J, Koning G, Reiber JHC; Quantitative Measurements in IVUS Image. International Journal of Cardiac Imaging 15: , 1999.St. Jude Medical. Data on file.Volcano Corporation, R-100 Instructions for Use.Boston Scientific Corporation, Galaxy Instructions for Use.Prati F, Regar E, Mintz GS, et al. Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: Physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis. Eur Heart J. 2010;31(4):