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Le CRNH-IdF Centre de Recherches en Nutrition Humaine d’Ile de France Alain GRYNBERG.

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Presentation on theme: "Le CRNH-IdF Centre de Recherches en Nutrition Humaine d’Ile de France Alain GRYNBERG."— Presentation transcript:

1 Le CRNH-IdF Centre de Recherches en Nutrition Humaine d’Ile de France Alain GRYNBERG

2 Clinical investigation Basic science CV risk diabetes (Jean Verdier) Food economy (INRA) Obesity center genotyping (La Pitié) Gut, satiety digestion CRV ( Avicennes ) Epidemiology (INRA-INSERM-Paris13) Protein, satiety digestion (INRA, AgroParisTech) Adipose tissue (INSERM, Paris 6) 150100/y

3 URA 1303 ALISS LG Soler INRA Ivry Gastroenterology -Hepatology R Benamouzig AVC-UP13 CRV R Benamouzig AVC-UP13 Nutrition JM Oppert LPS-UP6 Genotyping K Clément Ambulatory Exploration JM Oppert LPS-UP6 Endocrinology- diabetology- Nutrition P Valensi JV-UP13 UMR Inserm U872 K Clément UP6 U914 D Tome Agroparistech Endocrinology- Diabetology G Reach AVC-UP13 COPIL Scientific council Direction UMR U557 /U1125 S Hercberg SMBH-UP13 Gut, satiety Obesity / AdT compliance Risk factors Clinical investigations Epidemiology Economy

4 Scientific Activity 1 Dietary behaviour & food consumption General population Specific populations Variability Typologies dietary behaviour and consumption children, elderly, socio-demographic and socio- economic categories, diseased populations evolution of behaviour, regional variations food consumption data collection & new tools design, methodology for global nutrition and creation of dietary typologies

5 Scientific Activity 2 Determinant factors of behaviour on food consumption & nutritional status economical social sensorial psycho-physiological physio-pathological costs vs nutritional quality, socio-economic level, food supply vs demand taste training, food acceptability, lifestyle, life cycles, … hunger & satiety, satiety in the course of meal, attitudes and beliefs, energy density in food, portion size, conviviality & stimuli initiation and stop of eating, mechanisms of nycthemeral periodicity; conditioning and training physical activity, physiological and pathological situations

6 Scientific Activity 3 Dietary behaviour & health Quality of life Physiological functions Risk factors Morbi-mortality Interactions genetic factors / risk factors / behaviour hormonal, cardiovascular, adipose, digestive overweight, HTA, dyslipidemia, metabolic syndrome

7 Prevention strategies Market & behaviour Social marketing of information Transfer to population Effects of information on behaviour & corpulence Effects of information and product characteristics on food choices Education strategies for health considering population specificities. Compliance to nutritional recommendations Scientific Activity 4

8 Main clinical explorations available in Paris-13 sites Indirect calorimetry stable isotope tracers biphotonic absorptiometry Avicenne Pr R Benamouzig, Dr G Airinei Gastro-entero-hepatology  300 m2 heavy clinical exploration  Body composition  Ambulatory and resting energy expenditure  Qualitative and quantitative analysis of dietary behaviour  Metabolic & hormonal profile  Behaviour study boxes  Intestinal perfusion coupled to stable isotope tracers  Gut motility and gastric emptying (stable isotopes-echography)  Digestive tract biopsies, faecal and colonic flora

9 Main clinical explorations available in Paris-13 sites Jean Verdier Hospital Pr Paul Valensi, Pr Emmanuel Cosson Endocrinology, CV risk factors  Body composition  Ambulatory and resting energy expenditure  Qualitative and quantitative analysis of dietary behaviour  Metabolic & hormonal profile  Insulin-resistance coupled to calorimetry  Insulin secretion and sensibility to insulin  Peripheral endothelial function, artery compliance and CV autonomic activity  CV activity & echocardiography  Non invasive AGE measurement  Continuous glycaemic profile (G-Holter) Microcirculation by laser doppler Arterial compliance endothelial function Body composition

10 Main clinical explorations available in Paris 6 site La Pitié Salpétrière Pr JM Oppert, Pr K. Clément Obesity, adipose tissue  Unit of ambulatory exploration in obesity  Ambulatory and resting energy expenditure  Body composition  Qualitative and quantitative analysis of dietary behaviour  Metabolic & hormonal profile  Exercice training for obese patients  Adipose tissue phenotyping  Functional genomic  Genetic epidemiology, mutations & polymorphisms

11 The Projet : Phenotyping Harmonization Body composition Hormonal & metabolic profile endothelial function glycaemic profile Free living investigations technical protocols & equipment harmonization CRNH IdF AVC LPS JV AVC LPS JV IdF Auvergne Ouest Rhone Alpes

12 The Projet : Scientific Development Diabetes, CVD Subclinical cardio-vascular changes in the alterations of vago- sympathetic balance in prediabetes Postprandial changes in the vago-sympathetic balance across the glycemic continuum from normoglycemia to prediabetes and diabetes Geographic origin, psycho-social deprivation and diet as predictive factors for gestational diabetes mellitus Digestion, Satiety Microbiota Quality of the source of proteins Obesity Microbiota


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