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Fungal Infections, Pathogenesis and Treatment

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Presentation on theme: "Fungal Infections, Pathogenesis and Treatment"— Presentation transcript:

1 Fungal Infections, Pathogenesis and Treatment

2 Fungal infections 400 out of 75,000 Primary infections
Opportunistic infections Myco-toxins Allergy

3 Mycoses Superficial and cutaneous Subcutaneous Deep (systemic)

4 Examples of yeast of medical importance
Candida species Cryptococcus neoformans Malassezia species

5 Examples of moulds of medical importance
Dermatophytes Aspergillus species Zygomycetes

6 Superficial and Cutaneous Mycoses
Skin, hair, nail and mucus membranes Most common World-wide Ringworm infections du to Dermatophytes Yeast infections due to Candida

7 pityriasis versicolor

8 pityriasis versicolor
Direct examination pityriasis versicolor Filaments are not seen at unaffected skin sites or in culture

9 Tinea nigra

10 Skin scrapings Tinea nigra

11 Intertrigo caused by Canddia albicans

12 Dermatophytosis Dermatophytosis caused by M. canis following contact with infectious cat

13 Dermatophytosis direct skin examination

14 Dermatophytosis

15 Fungal nail infection

16 Subcutaneous Mycoses Skin, subcutaneous tissues, fascia and bone
Localized Trauma More in tropics Mycetoma, chromomycosis and sporotrichosis

17 Mycetoma

18 Mycetoma

19 Sporotrichosis A 60-year-old woman developed multiple subcutaneous
nodules and abscesses on her right hand and forearm 7 days after finger thorn prick

20 Chromoblastomycosis: Fonsecaea pedrosoi
Classical Chromoblastomycosis: Fonsecaea pedrosoi De Hoog, Centraalbureau voor Schimmelcultures

21 Nodulose chromoblastomycosis (Senegal): Fonsecaea pedrosoi
De Hoog, Centraalbureau voor Schimmelcultures

22 Systemic Mycoses Deep-seated Inhalation Primary (restricted)
Opportunistic (world-wide)

23 Opportunistic fungal infections
Aspergillosis Pulmonary Disseminated Para nasal sinusitis Candidiasis Candidemia Cryptococcus meningitis

24 Polyene antifungal agents
Amphotericin B Nystatin

25 Azoles antifungal agents
Clotrimazole Econazole Ketoconazole Miconazole Fluconazole Itraconazole Posaconazole Voriconazole

26 Other antifungal agents
Echinocandins Anidulafungin Caspofungin Micafungin Terbinafine 5-fluorocytosine

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