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Fungal Infections, Pathogenesis and Treatment
400 out of 75,000 Primary infections Opportunistic infections Myco-toxins Allergy
Superficial and cutaneous Subcutaneous Deep (systemic)
Examples of yeast of medical importance Candida species Candida species Cryptococcus neoformans Cryptococcus neoformans Malassezia species Malassezia species
Examples of moulds of medical importance Dermatophytes Dermatophytes Aspergillus species Aspergillus species Zygomycetes Zygomycetes
Skin, hair, nail and mucus membranes Most common World-wide Ringworm infections du to Dermatophytes Yeast infections due to Candida
Dermatophytosis caused by M. canis following contact with infectious cat Dermatophytosis
Skin, subcutaneous tissues, fascia and bone Localized Trauma More in tropics Mycetoma, chromomycosis and sporotrichosis
Sporotrichosis A 60-year-old woman developed multiple subcutaneous nodules and abscesses on her right hand and forearm 7 days after finger thorn prick
Classical Chromoblastomycosis: Fonsecaea pedrosoi De Hoog, Centraalbureau voor Schimmelcultures
Nodulose chromoblastomycosis (Senegal): Fonsecaea pedrosoi De Hoog, Centraalbureau voor Schimmelcultures
Deep-seated Inhalation Primary (restricted) Opportunistic (world-wide)
Aspergillosis Pulmonary Disseminated Para nasal sinusitis Candidiasis Pulmonary Candidemia Cryptococcus meningitis
Amphotericin B Nystatin
Clotrimazole Econazole Ketoconazole Miconazole Fluconazole Itraconazole Posaconazole Voriconazole
Echinocandins Anidulafungin Caspofungin Micafungin Terbinafine 5-fluorocytosine
OPPORTUNISTIC MYCOSES Sevtap Arikan, MD. OPPORTUNISTIC MYCOSES General features CAUSATIVE AGENTS Saprophyte in nature/found in normal flora HOST Immunosupressed.
An Introduction to Anti-fungal Pharmacology The following slides were generously supplied by Professor Russell E. Lewis, Pharm.D., BCPS University of Houston.
Phase I/ Module VII Dr Ekta, Microbiology 1 Classification & General Properties of Fungi.
FUNGAL KERATITIS IN MAN Andrew Tullo Royal Eye Hospital, Manchester.
FUNGAL DISEASES IN THE RESPIRATORY, EXCRETORY & CIRCULATORY SYSTEMS By: Macatangay, Rachel C. BS BIO 3A.
Microbiology 205 Georgetta Seidel. Definitions Mycologists--scientists who study fungi Mycology--scientific discipline dealing with fungi Mycoses--diseases.
1 Adult Cutaneous Fungal Infections Medical Student Core Curriculum in Dermatology Last updated May 23, 2011.
Clin Med II Infectious Disease Lecture 1 – Fungal Diseases – Spirochetal Diseases – Mycobacterial Diseases.
Recent Update In The Management Of Invasive Candidiasis.
Dr Ekta Chourasia,Microbiology Laboratory Diagnosis of Fungal Infections III MBBS.
Epidemiology & Risk Factors Adilia Warris, MD Nijmegen University Center of Infectious Diseases, UMC St Radboud Adilia Warris MD PhD Pediatric infectious.
MOST COMMONLY PRESCRIBED ANTIFUNGAL AND ANTIVIRAL MEDICATIONS Anneliese Bodding-Long University of Washington Doctor of Pharmacy Candidate, 2012
Antifungal treatment: Past and Present Malcolm Richardson PhD, FIBiol, FRCPath University of Helsinki.
Farmaci antifunginei 1] Dermatophytes MicrosporumMicrosporum, Epidermophyton e TrichophytonEpidermophytonTrichophyton 2] Candida 3] Aspergillus 4] Cryptococcus.
REVIEW OF MEDICAL MICROBIOLOGY Infections of Respiratory tract Cardiovascular system Gastrointestinal tract Skin and soft tissue Central nervous system.
Lipid Amphotericin B Formulations and the Echinocandins Russell E. Lewis, Pharm.D. Assistant Professor.
My Home Town a Few Days Ago. Relevance of Combination Antifungal Therapy: Some Key Questions Is there a need for combination therapy in the first place?
C RYPTOCOCCAL M ENINGITIS Learning Objectives Introduction C.Neoformans C. Gatti Clinical Features Space Occupying CryptococcusSpace Occupying Cryptococcus.
Amphotericin- or Echinocandin-Based Antifungal Prophylaxis Approaches Jo-Anne Young, MD, FACP, FIDSA.
Invasive mycoses in cystic fibrosis and lung transplant Elio Castagnola Infectious Diseases Unit G.Gaslini Children Hospital Genoa - Italy.
Treatment of Invasive Aspergillosis: Polyenes, Azoles, Echinocandins? Thomas F. Patterson, MD Professor of Medicine Director, San Antonio Center for Medical.
Dr. Fawzia Al-Otaibi. SYMPTOM Chronic head ache Neck or back pain Change in personality Facial weakness Double vision,visual loss Arm and.
What are fungi? Fungi belong to their own special kingdom as they differ from both plants and animals. Fungi are eukaryotic cells. The fungal kingdom is.
Latest Developments in the Treatment of Invasive Aspergillosis William J. Steinbach, MD Assistant Professor of Pediatrics, Molecular Genetics, and Microbiology.
Dante Luiz Escuissato. Infections are related to specific immunity defects. Phagocyte abnormalities and intravenous catheters: Aspergillus and Candida.
Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Introduction to Clinical Pharmacology Chapter 12 Antifungal and Antiparasitic Drugs.
ALOK SINHA Department of Medicine Manipal College of Medical Sciences Pokhara, Nepal.
The Importance of Early Appropriate Therapy of Invasive Aspergillosis Helen Whamond Boucher, MD Division of Infectious Diseases Tufts University-New England.
The extraordinary spectrum of diseases caused by Aspergillus David W. Denning Wythenshawe Hospital University of Manchester.
SURGICAL INFECTIONS & ANTIBIOTICS M K ALAM MS, FRCS Prof. & Consultant Surgeon College of Medicine & RCH.
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