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Fungal Infections, Pathogenesis and Treatment.  400 out of 75,000  Primary infections  Opportunistic infections  Myco-toxins  Allergy.

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Presentation on theme: "Fungal Infections, Pathogenesis and Treatment.  400 out of 75,000  Primary infections  Opportunistic infections  Myco-toxins  Allergy."— Presentation transcript:

1 Fungal Infections, Pathogenesis and Treatment

2  400 out of 75,000  Primary infections  Opportunistic infections  Myco-toxins  Allergy

3  Superficial and cutaneous  Subcutaneous  Deep (systemic)

4 Examples of yeast of medical importance Candida species Candida species Cryptococcus neoformans Cryptococcus neoformans Malassezia species Malassezia species

5 Examples of moulds of medical importance Dermatophytes Dermatophytes Aspergillus species Aspergillus species Zygomycetes Zygomycetes

6  Skin, hair, nail and mucus membranes  Most common  World-wide  Ringworm infections du to Dermatophytes  Yeast infections due to Candida

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10 Skin scrapings

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12 Dermatophytosis caused by M. canis following contact with infectious cat Dermatophytosis

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16  Skin, subcutaneous tissues, fascia and bone  Localized  Trauma  More in tropics  Mycetoma, chromomycosis and sporotrichosis

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19 Sporotrichosis A 60-year-old woman developed multiple subcutaneous nodules and abscesses on her right hand and forearm 7 days after finger thorn prick

20 Classical Chromoblastomycosis: Fonsecaea pedrosoi De Hoog, Centraalbureau voor Schimmelcultures

21 Nodulose chromoblastomycosis (Senegal): Fonsecaea pedrosoi De Hoog, Centraalbureau voor Schimmelcultures

22  Deep-seated  Inhalation  Primary (restricted)  Opportunistic (world-wide)

23  Aspergillosis  Pulmonary  Disseminated  Para nasal sinusitis  Candidiasis  Pulmonary  Candidemia  Cryptococcus meningitis

24  Amphotericin B  Nystatin

25  Clotrimazole  Econazole  Ketoconazole  Miconazole  Fluconazole  Itraconazole  Posaconazole  Voriconazole

26  Echinocandins  Anidulafungin  Caspofungin  Micafungin  Terbinafine  5-fluorocytosine


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