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CTCF: the protein, the binding partners, the binding sites and their chromatin loops by Sjoerd Johannes Bastiaan Holwerda, and Wouter de Laat Philosophical.

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Presentation on theme: "CTCF: the protein, the binding partners, the binding sites and their chromatin loops by Sjoerd Johannes Bastiaan Holwerda, and Wouter de Laat Philosophical."— Presentation transcript:

1 CTCF: the protein, the binding partners, the binding sites and their chromatin loops by Sjoerd Johannes Bastiaan Holwerda, and Wouter de Laat Philosophical Transactions B Volume 368(1620): June 19, 2013 ©2013 by The Royal Society

2 CTCF, chromatin loops and transcription regulation at selected gene loci. Sjoerd Johannes Bastiaan Holwerda, and Wouter de Laat Phil. Trans. R. Soc. B 2013;368: ©2013 by The Royal Society

3 A versatile role for CTCF in chromatin biology. Sjoerd Johannes Bastiaan Holwerda, and Wouter de Laat Phil. Trans. R. Soc. B 2013;368: ©2013 by The Royal Society

4 CTCF acts as an insulator by hampering DNA contacts across its binding sites. Sjoerd Johannes Bastiaan Holwerda, and Wouter de Laat Phil. Trans. R. Soc. B 2013;368: ©2013 by The Royal Society


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