Presentation on theme: "Reviews: update Hamerman, J. A., Ogasawara, K., Lanier, L. L. (2005). NK cells in innate immunity. Curr Opin Immunol 17, 29-35. W.M. Yokoyama and S. Kim."— Presentation transcript:
Reviews: update Hamerman, J. A., Ogasawara, K., Lanier, L. L. (2005). NK cells in innate immunity. Curr Opin Immunol 17, 29-35. W.M. Yokoyama and S. Kim (2006). Licensing of natural killer Cells by self-major histocompatibility complex class I. Immunol. Rev. 214, 143-154. J.G. Sambrook and S. Beck (2007). Evolutionary vignettes of natural killer cell receptors. Curr. Op. Immun. 19. 553-560 E. Tupin, Y. Kinjo and M. Kronenberg (2007). The unique role of natural killer T cells in the response to microorganisms. Nat. Rev. Microbiol. 5, 405-417. H.-G. Ljunggren and K.-J. Malmberg (2007). Propsects for the use of NK cells in immunotherapy of human cancer. Nat. Rev. Immun. 7, 329-339.
„NK“ receptors on T lymphocytes and other cell types KIR und CD94/NKG2A /NKG2C: nur NK cells und Subpopulations von NKT cells ILT, LAIR, NKG2D: auch auf anderen Leukozyten Monocyten, Makrophagen, dendritischen Zellen, B Zellen
Acquisition of receptor repertoire Hypothesis: NK cell education (not really understood) each NK cell has several inhibitory and activating receptors, developing NK cell initiates inhibitory receptor gene expression in a sequential, cumulative and stochastic fashion class I deficient mice: NK cells are tolerant „at least one“ hypothesis: formation of repertoire regulated such that „at least one“ inhibitory receptor for one or another self MHC is present
Possibility: first stimulatory receptors, induce expression inhibitory receptors until zero sum between stimulation and Inhibition Question: NK cells are alloreactive but self-tolerant, how ??