Presentation on theme: "The Structure of Phosphor Lipid Membranes Embedded with n-Alcohols Investigated by SAXS and MD-Simulations Ulf Rørbæk Pedersen (RUC) Supervisors Dorthe."— Presentation transcript:
The Structure of Phosphor Lipid Membranes Embedded with n-Alcohols Investigated by SAXS and MD-Simulations Ulf Rørbæk Pedersen (RUC) Supervisors Dorthe Posselt (RUC) Peter Westh (RUC) Güenter Peters (DTU)
Introduction Method: ● Small angle x-ray scattering (SAXS) ● Molecular Dynamics Simulations (MD-simulations) System: DMPC/hexanol (MD-simulations) and similar systems (SAXS)
SAXS Model Smearing from line shaped beam in Kratky camera ( ) q = |k in - k out |
SAXS data DMPC/hexan ol DMPC DMPC/hexanol elektron dencity [a.u.]
Summary Alcohol molecules intercalate with the hydroxy group in the hydrophilic part and the acyl chain parallel to the fatty acids n-hexanol in a membrane introduces ● a reduction of the thickness (SAXS) ● a condensations of the area (MD) ● a softer membrane (MD) ● more free volume in inner part of membrane (MD) ● more order in outer part of membrane (MD) ● less order in inner part of membrane (MD)
Perspectives ● How can we modify the properties of a membrane by doping? ● Permeability ● Concentration dependence ● The dependence of alcohol length ● Other doping molecules (cholesterol, other anesthesia) ● MD-Pulling experiment
Your consent to our cookies if you continue to use this website.