Presentation on theme: "Department of Genetics, Microbiology and Toxicology (GMT) Radiation Biology Prof. Andrzej Wojcik Prof. Mats Harms-Ringdahl Toxicology Prof. Thomas Helleday."— Presentation transcript:
Department of Genetics, Microbiology and Toxicology (GMT) Radiation Biology Prof. Andrzej Wojcik Prof. Mats Harms-Ringdahl Toxicology Prof. Thomas Helleday Prof. Ulf Rannug Prof. Dag Jenssen Centre for Radiation Protection Research (CRPR) (CRPR) Molecular Mechanisms in Cancer / Dag Jenssen, GMT
Radiation Biology (AW & MHR) 2 Profs 1 Postdoc 5 PhD students 2 Master students Mechanisms of cellular and systemic effects of exposure to ionising radiation EU grants Swedish Radiation Safety Authority
Radiation Biology (AW & MHR) Mechanisms of individual sensitivity to ionising radiation: Differences in DNA-damage response pathways between cohorts of patients with normal or severe healthy tissue reactions to tumour therapy. Differences in DNA-damage response pathways between cohorts of patients with normal or severe healthy tissue reactions to tumour therapy. Screening for polymorphisms in genes for DNA- repair, cell cycle regulation and apotosis Screening for polymorphisms in genes for DNA- repair, cell cycle regulation and apotosis Search for diagnostic tools to identify the persons at risk. Search for diagnostic tools to identify the persons at risk. Patient with severe side-effect following radiotherapy
Radiation Biology (AW & MHR) What are the risks of radiation at low doses? Can we improve biological dosimetry? New technologies will determine doses with high precision? New biomarkers for DNA- damage response pathways Is the dose response curve non-linear? Identification of new response pathways for very low doses. ?
Professor Thomas Helleday’s group SU group 1 Prof 10 Postdocs & senior scientists 8 PhD students 1 Master students DNA repair in cancer therapy Main grants from: Swedish Scientific Research Council (VR) Swedish Pain Relief Foundation (Smärtafonden) Swedish Cancer Foundation (Cancerfonden) Swedish Children’s Cancer Foundation (Barncancerfonden) Oxford group 6 Postdocs 7 DPhil students
Niklas Schultz, Helge Gad, Fredrik Johansson, Anne Lagerkvist, Linda Savolainen, Ingegerd Elvers, Cecilia Ström, Petra Groth, Firas Al-Ubadi, Ivaylo Stoimenov, Kristian Grimberg, Guoli Liu, Muntasir Mamun Research areas Stalling of Replication fork and Replication RestartStalling of Replication fork and Replication Restart Homologous recombinationHomologous recombination DNA replication terminationDNA replication termination DNA repair in cancer (cells + clinical material)DNA repair in cancer (cells + clinical material) SU - DNA Repair team
SU - Biochemistry/proteomics Ann-Sofie Jemth, Olga Loseva Research areas Poly (ADP ribose) polymerasesPoly (ADP ribose) polymerases Proteomics after DNA damageProteomics after DNA damage Purification of protein targets for cancer treatmentPurification of protein targets for cancer treatment SU – Cancer Biology Tatjana Djureinovic, Evgenia Gubanova Research areas DNA damage signalling in cancerDNA damage signalling in cancer Evaluation of targets for cancer treatmentEvaluation of targets for cancer treatment
SciLifeLab - High-Throughput Screening Bo Lundgren Research areas RNAi library screens in cellsRNAi library screens in cells Identify targets for cancer treatmentsIdentify targets for cancer treatments Map functional genetic networksMap functional genetic networks SU – Medical Chemistry Martin Scobie, Tobias Koolmeister Research areas Lead optimisation - Parallell organic chemistry synthesisLead optimisation - Parallell organic chemistry synthesis
Professor Ulf Rannugs group 1 Prof 1 Postdoc 3 PhD students 1 Master student Natural non-persistent bioactive aryl hydrocarbon receptor ligands in humans The Swedish research Council FORMAS
Professor Ulf Rannug, cont. AhR NFĸB Formation and metabolism of the suggested physiological Ah receptor ligand 6-formyl- indolo[3,2-b]carbazole (FICZ) HPLC, LC/MS/MS Recombinant human enzymes Human cells in vitro Human blood, plasma and urine samples
Professor Ulf Rannug, cont. TRYPTOPHAN PROLIFERATION/APOPTOSIS DEVELOPMENT DIFFERENTIATION HOMEOSTASIS IMMUNE RESPONS INFLAMMATION NEUROENDOCRINE FUNCTIONS RESPONSES STRESS RESPONSES Genomic and non-genomic regulation ARYL HYDROCARBON RECEPTOR (AhR) SECOND MESSENGERS OTHER R RECEPTORS (LXR) FICZ Activeligand oxFICZ Inactiveligand CYP1AOX TRYPTAMINE I-3-A The new AhR paradigm
Professor Dag Jenssen’s group 2 Profs 2 Postdocs 2 PhD students 3 Master students Molecular/cellular mechanisms for induced mutations EU grants Swedish Cancer Society Swedish Radiation Protection Authority / Dag Jenssen, GMT
Professor Dag Jenssen, cont. Mechanisms involved in the repair of genomic DNA intra-strand cross-links (Cf, 2010-2013) The basis for cancer risk assessment of lifestyle factors Cell culture models DNA repair DNA replication Mutation assay DNA sequencing
Professor Dag Jenssen, cont. Molecular/cellular protection mechanisms against carcinogenic constituents in food (EU, 2010-2014) The basis for developing Functional Foods / Dag Jenssen, GMT
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