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LIPOSOMES Unilamellar phospholipid liposomes are hollow spherical particles consisting of single phospholipid bilayer shell with the aqueous phase inside.

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Presentation on theme: "LIPOSOMES Unilamellar phospholipid liposomes are hollow spherical particles consisting of single phospholipid bilayer shell with the aqueous phase inside."— Presentation transcript:

1 LIPOSOMES Unilamellar phospholipid liposomes are hollow spherical particles consisting of single phospholipid bilayer shell with the aqueous phase inside and outside of this shell. The lamellar phases of phospholipids wherein stacked phospholipid bilayers are separated by layers of the aqueous phase convert spontaneously into multilamellar liposomes at increased water content.

2 Neutron scattering and LLB:

3 Polydispersity SANS

4 Evaluation Guinier approximation: Fit:

5 Single-shell Multi-shell Multi-shell + Linear profile of headgroup Multi-shell + Triangular profile of headgroup Models:

6 Contrast Variation and Guinier approximation

7 Contrast Variation and Fitting

8 Effect of additional amphiphilic molecules Thin disc with thickness h r=1 Full sphere with radius R r=3 Hollow sphere with radii R 1, R 1 r≈1 (thin layer) Full cylinder with radius R r=2

9 YUMO

10 PAXE

11


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