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FHHS402_practical_proforma

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Principles of Pharmacology INVESTIGATION OF ASPIRIN OVERDOSE USING SALICYLATE ASSAY Coursework 1 This assignment must be submitted via the online coursework submission tool found on Blackboard. In addition, a hard copy of the report must also be submitted. The last opportunity for submission before 8:00am on Monday 7th January 2015. Instructions to students – please read carefully Please use this proforma to submit the written part of your assessment for Coursework 1. The proforma is structured and you should adhere to the instructions provided throughout . (2) Your text MUST be written in the boxes provided and should be presented in Arial or Calibri 12 pt. Smaller text or that presented outside of, or in additional boxes will not be marked. Your answers MUST be word processed and apart from sections 1 and 3, each question has a word limit (Maximum number in brackets). Expand the boxes as required in order to fit in your text. (3) Yow will be asked to append a copy of the data table provided on Blackboard. Please follow the specific instructions concerning this later in the proforma. (4) The paper copy version of your report will be reunited with the calibration data graph you submitted in class. The latter is a record of your attendance of the practical session. (5) Please ensure that any references used are from recognised peer-reviewed sources and that both citation in the text and bibliography section conform to the Harvard format. (6) There are 45 marks available in this assessment, representing 40% of the available marks for the module. December 2014 FHHS402_practical_proforma

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1. Explain carefully what the results of the screening test indicate, ensuring that you refer to each of the five solutions tested.(hint: You may wish to insert a small table here in order to represent these qualitative findings) (5 marks) 2. Why did a precipitate form on addition of Trinder’s reagent to the serum sample but not to the urine sample? (150 words max; 4 marks) 3. Your fully labelled graph of calibration data and estimates of the unknown salicylate concentration submitted separately, will be attached to the end of your paper copy (6 marks) 4. Using Excel, tabulate the class results (from the module Blackboard site under ‘Assessments’) and calculate the mean and standard deviation. Insert your table at the end of this report (both paper and online submitted copies). Briefly comment on any difference between your results and the class mean result. In your answer, make sure that you show that you understand the meaning of standard deviation (150 words max; 6 marks) December 2014 FHHS402_practical_proforma

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5. Do your results indicate that the patient has taken an overdose of aspirin? Explain why your conclusion might be different if you were informed that the patient was suffering from rheumatoid arthritis. (200 words max: 6 marks) 6. List the side effects that might be experienced by a patient who has taken a suspected aspirin overdose (20 words max; 3 marks) 7. The pKa value of aspirin is 3.0. (i) Name the part of the GI tract where the environmental pH would be expected to favour rapid absorption. (ii) Is this where most absorption actually occurs? If not, identify an alternative site in the GI tract and briefly explain your answer (150 words max; marks) 8. Briefly explain the molecular mode of action for aspirin, when it is used as an anti-inflammatory and/or antipyretic drug (200 words max; 5 marks) December 2014 FHHS402_practical_proforma

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9. Provide one example each of the systematic (chemical) , trivial, generic and trade names for aspirin (4 words max; 2 marks) References. List here (correctly cited using the Harvard format) (2 marks) December 2014 FHHS402_practical_proforma


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