Presentation on theme: "Introduction to Microbiology H. GEE. MD, FRCOG Hon. Assoc. Clinical Professor University of Warwick."— Presentation transcript:
Introduction to Microbiology H. GEE. MD, FRCOG Hon. Assoc. Clinical Professor University of Warwick
Peter Gayo Munthali Consultant Microbiologist UHCW
What is Microbiology The study of micro-organisms –Bacteria (Bacteriology) –Viruses (Virology) –Parasites (Parasitology) –Fungi (Mycology) Human, Animals, Plants
Aim To introduce general principles in microbiology with an emphasis on bacteria and viruses
Objectives By the end of the session you should be able to; –Distinguish between gram-positive and gram- negative bacteria –Describe bacteria by their shape as either cocci or rods –Name some common bacterial and viral diseases linked to their causative organisms –Describe in broad terms, how antibiotics work on bacteria –Describe the difference between bacteria and viruses.
Bacteria Description Unicellular Prokaryotic –Primitive nucleus No nucleus membrane Genome Single circular molecule double stranded DNA Can harbour independent small circular DNA molecules called plasmids Structure Rigid wall which determines their shape
Enzymatic Cleavage Identical Daughter cells Bacterial Cell Division Division bacterial chromosome replicates leading to two identical chromosomes DNA relaxation and duplication Super coiled DNA Duplication of the DNA
Attachment +/-Evade natural protection and cleansing mechanisms Entry into body Local or general spread Evade immediate local defences Multiplication Evasion of host defences Evade immune and other defences for growth in the hostto be completed Shedding from body Leave body at a site and on a scale that ensures spread to fresh host- transmission Obligatory steps for infection
Relationship with humans We are sterile in utero Shortly after birth colonised Of 100000000 bacterial only 1000 are successful –Suggests highly evolved
Bacteria and Human body Bacteria >10x than human cells in the body (10¹ versus 10¹³) – Skin surface and in deep layers –Saliva and oral mucosa –Gastrointestinal tracts –Genital tract Normal microbiota or microflora –Beneficial to human health –Opportunistic infections < 10% culturable Others not part of normal microbiota –Pathogenic –Opportunistic pathogens
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