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Development of the Circulatory System Development of cardiovascular system Development of lymphatic vascular system.

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Presentation on theme: "Development of the Circulatory System Development of cardiovascular system Development of lymphatic vascular system."— Presentation transcript:

1 Development of the Circulatory System Development of cardiovascular system Development of lymphatic vascular system

2 The cardiovascular system is derived from the mesoderm. It appears in the middle of the 3rd week. Blood circulation starts by the end of the 3rd week. Some changes take place at birth and in the 1st postnatal month. overview

3 Key points 1.Development of primitive cardiovascular system 2.Development of Heart 3.Formation and modification of aortic arches 4.Circulation before and after birth 5.Congenital Malformations ※

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5 Cardiogenic area Oropharyngeal membrane Primitive Cardiovascular System

6 Primitive cardiovascular system Yolk sac mesenchyme cells blood islands Central C Peripheral C Primitive Blood cell Endothelia C Blood C Vessels Endothelial tubes of intraembryo and extraembryo are connected with each other by body stalk.

7 Yolk sac mesenchyme cells blood islands Central C Peripheral C Primitive Blood cell Endothelia C Blood C Vessels primitive cardiovascular system Vessels net

8 ① heart tube : 2 tubes  1 tube  Primitive heart ② arteries ③ veins 20d Heart tubes End of 4w Primitive heart 4w4w

9 ① heart tube ② arteries ③ veins 2 dorsal A  1 aorta , many branches Few pairs of vitelline A 1 pair of umbilical A 6 pairs of aortic arches 20d4w4wEnd of 4w Dorsal A Dorsal aorta Aortic arches Umbilical A Vitelline A

10 1 pair of anterior cardinal V 1 pair of posterior cardinal V 1 pair of vitelline V 1 pair of umbilical V 20d4w4wEnd of 4w A cardinal VPosterior Umbilical V Vitelline VCommon cardinal V Common cardinal V ① heart tube ② arteries ③ veins heart

11 vitelline, umbilical and embryonic circulation. Three separate circulations

12 Development of the Heart ► Development of the heart tube ► Morphogenesis of the heart ► Partitioning of Heart Chambers ► Development of sinus venosus and differentiation of veins

13 Cardiogenic area Oropharyngeal membrane oropharyngeal Cardiogenic area is anterior to the oropharyngeal membrane and the neural plate. Development of the heart tube

14 A.About 18~19d, a cavity appears in the cardiogenic area --pericardiac cavity B. Ventral of the cavity is cardiaogenic cords --cardiaogenic plate Pericardial cavity Buccopharyngeal M cardiaogenic plate Development of the heart tube

15 C. cardiaogenic plate becomes hollow--cardiac tube Pericardial cavity cardiac tube The 20 th d Development of the heart tube

16 D. As the embryo folds cephalocaudally, the developing heart tube bulges more and more into the pericardial cavity. Pericardial cavity cardiac tube The 22 nd d Development of the heart tube

17 E. The paired heart tubes merge except at their caudalmost ends. F. The tube remains attached to the dorsal side of the pericardial cavity by the dorsal mesocardium. Pericardial cavity cardiac tube The 28 th d Development of the heart tube

18 G. Cephalic end  Arteries , Caudal end  Veins Pericardial cavity Heart tube Development of the heart tube Cephalic end Caudal end

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20 Pericardial cavity

21 Endocardial heart tube → endocardium Myoepicardial mantle → myocardium, epicardium Cardiac jelly → subendocardial tissue Wall of primitive heart tube

22 Vein end Cardiac tube Artery end The 21 st d A. Part of the cardiac tubes merged B. Cephalic end  A Caudal end  V Morphogenesis of the heart

23 atrium ventricle bulbus cordis The 22 nd d C. Heart tubes almost merged D. Three expansions bulbus cordis( 心球 ) Ventricle( 心室 ) Atrium( 心房 ) Morphogenesis of the heart

24 The 23 rd d E. The 4 th expansion, the sinus venosus( 静脉窦 ) appears F. The truncus arteriosus( 动脉 干 )appears G. The heart tube starts to bend atrium bulbus cordis truncus arteriosus sinus venosus ventricle Morphogenesis of the heart

25 The 24 th d H.The cephalic portion bends ventrally, caudally, and to the right. The caudal part shifts dorsocranially and to the left. Form a ‘U’ like structure, the cardiac loop (bulboventricular loop). Bulboventricular loop Sinus venosus truncus arteriosus Morphogenesis of the heart

26 The 35 th d I. The bulboventricular loop keeps turning, the atrium shifts to the cephalodorsal of the ventricle G. Two atria and two ventricles atrium Aortic arches ventricle The normal heart shape was established, but partitioning has not completed Morphogenesis of the heart

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29 Development of the Heart ► Development of the heart tube ► Morphogenesis of the heart ► Partitioning of Heart Chambers ► Development of sinus venosus and differentiation of veins

30 Partitioning of Heart Chambers ►Division of atrioventricular canal ► Partitiioning of the primitive atrium ► Partitioning of the primitive ventricle ► Division of truncus and bulbus

31 Subendocardial tissue → dorsal and ventral endocardial cushions → fuse → right and left canals Division of atrioventricular canal

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33 The 4 th w atria Endocardiac cushion ventricle Septum formation in part arises from development of endocardial cushion. Many malformations are related to abnormal cushion morphogenesis.

34 The 5 th w Fusion of the opposing superior and inferior cushions divides the orifice into R and L aterioventricular canals. L AV orifice R AV orifice Endocardiac cushion

35 The 4th month bicuspid tricuspid biscuspid tricuspid Left Right Endocardiac cushion

36 Partitioning of Heart Chambers ►Division of atrioventricular canal ► Partitiioning of the primitive atrium ► Partitioning of the primitive ventricle ► Division of truncus and bulbus


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