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Development of circulatory system 1. Establishment of primitive cardiovascular system 2. Development of heart (1) Formation of primitive heart (2) Establishment.

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Presentation on theme: "Development of circulatory system 1. Establishment of primitive cardiovascular system 2. Development of heart (1) Formation of primitive heart (2) Establishment."— Presentation transcript:

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2 Development of circulatory system 1. Establishment of primitive cardiovascular system 2. Development of heart (1) Formation of primitive heart (2) Establishment of configuration of heart (3) Compartmentation of heart 3. Blood circulation of fetus 4. Abnormality of circulatory system

3 Establishment of primitive cardiovascular system  Development of blood vessel First: extraembryonic Second: endoembryonic 1. Extraembryonic (15th to 16th day) Extraembryonic mesoderm (Yolk sac) Blood island Endothelial tubule (periphery) Endothelial tubular meshwork Primitive blood cells (center) Extraembryonic mesoderm Body stalk, Chorion Endothelial tubular meshwork

4 2. Endoembryonic (18th to 20th day) Endoembryonic mesoderm (Mesenchyme) Endothelial tubule Endothelial tubular meshwork 3. The end of 3rd week Endoembryonic Body stalk Extraembryonic Communication Primitive cardiovascular system

5 Formation of blood island and blood vessel Extraembryonic mesoderm Primitive blood cells Endothelium

6 Development of primitive heart  Formation of primitive heart Cardiogenic region Pericardiac coelom 2 ( dorsal ) Cardiogenic plate 2 ( Ventral ) Cardiac tube 2 Head fold Cardiac tube 2 Pericardiac coelom 2 18th-19th day Cardiac tube 1 Pericardiac coelom 1 Fusion

7 Head fold: Pericardiac coelom: dorsal → ventral Cardiac tube: ventral → dorsal

8 Lateral fold: Pericardiac coelom: 2 → 1 Cardiac tube: 2 → 1 Pericardiac coelom Cardiac tube Foregut Cardiac tube Cardiac jelly Dorsal mesocardium Myocardium

9 Establishment of configuration of heart Straight tube Bulbus cordis —Ventricle— Atrium—Sinus venosus 2 shrink Pericardial fixation Pericardiac fixation ( 21th day ) (4th to 5th week) S-shaped Heart rudiment (35th day) U-shaped bulboventricular loop

10 Cardiac tube Ventricle Bulbus cordis Atrium Sinus venosus Distal : slightness, truncus arteriosus Middle : dilation, bulbus arteriosus cordis Proximal : primitive right ventricle Left horn Right horn Bulboventricular loop Protruding to right, ventral and tail

11 Establishment of configuration of heart Ventricle Atrium Truncus arteriosus Bulbus cordis

12 Establishment of configuration of heart

13 Ventral endocardiac cushion Dorsal endocardiac cushion Atrioventricular tube Left atrioventricular tube Right atrioventricular tube Compartmentation of heart 27-37th day 1.Compartmentation of atrioventricular tube

14 Compartmentation of primitive atrium ( 4th to 5th week)  Septum primum: end of 4th week Foramen primum : Foramen secundum: Foramen ovale: Valve of foramen ovale:  Septum secundum: end of 5th week

15 Right atrium Left atrium Foramen primum Septum primum Closing foramen primum Foramen secundum Forming foramen secundum Right ventricle Septum secundum Left ventricle Valve of forasmen ovale Foramen ovale

16 Compartmentation of primitive atrium

17  Muscular interventricular septum : end of 4the week Compartmentation of primitive ventricle ( 4th to 8th week)  Membranous interventricular septum: end of 7th week Interventricular foramen: Three origins: left, right bulbar ridge and endocardiac cushion

18 Left atrium Foramen primum Septum primum Closing foramen primum Foramen secundum Forming foramen secundum Right ventricle Septum secundum Left ventricle Valve of foramen ovale Foramen ovale Interventricular foramen Muscular interventricular septum Membranous interventricular septum

19 Development of heart (6th week) Muscular interventricular septum

20 Right bulbar ridge Left bulbar ridge Aortico-pulmonary septum Endocardiac cushion Membranous interventricular septum Interventricular foramen Muscular interventricular septum Formation of membranous septum

21 Compartmentation of truncus arteriosus and bulbus cordis (5th to 8th week) Inner part of truncus arteriosus and bulbus cordis Left, right Bulbar ridge (Spiral) Fusion Aorta Pulmonary artery Aortico- pulmonary septum ( Spiral )

22 Right bulbar ridge Aortico- pulmonary septum Left bulbar ridge

23 Development of heart (6th week) Bulbar ridge

24 Aortico-pulmonary septum Right pulmonary artery Aorta Aortico-pulmonary septum Compartmentation of truncus arteriosus and bulbus cordis

25 Blood circulation of fetus

26 Venous ductus

27 Arterial ductus

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30  Characteristics Ductus -- A ductus 、 V ductus Foramen -- Foramen ovale Umbilical vessels -- 2 A, 1 V

31 Alterations after birth ① Foramen ovale atresia ② Umbilical vessels atresia ③ V ductus atresia ④ A ductus atresia

32 Abnormality of circulatory system 1. Atrial septal defect 2. Ventricular septal defect 3. Abnormal compartmentation of truncus arteriosus 4. Patent ductus arteriosus

33 1. Atrial septal defect Reasons : Perforation of foramen ovale Over absorption of septum primum Undeveloped septum secundum Unclosed foramen ovale ① ② ③ ④ ①② ③④ = ② + ③

34 2. Ventricular septal defect Reasons: ① Unfused endocardial cushion, bulbar ridge and muscular septum ② Over absorption of membranous septum ① Membranousr septal defect: commonly ② Muscular septal defect: sparsely Right ventricle Left ventricle Interventricular foramen

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36 Abnormal compartmentation of truncus arteriosus Reasons: No spiral ① Incorrectly positioned of aorta and pulmonary artery Right ventricle Left ventricle Aorta Pulmonary artery

37 Reasons: Unequal compartmentation of aorta and pulmonary artery ② Narrow of aorta or pulmonary artery Narrow pulmonary artery Abnormal compartmentation of truncus arteriosus

38 Reasons: Unequal compartmentation of aorta and pulmonary artery ③ T etralogy of Fallot Narrow pulmonary artery, ventricular septal defect, aorta stride and right ventricle hypertrophy Roght ventricle Left ventricle

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40 Patent ductus arteriosus Ductus arteriosus remains open

41 Right positioned heart


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