The biological effect of shock waves can be specifically utilized to generate new tissue formation and successfully treat skin lesions
The biological effect of shock waves can be specifically utilized to generate new tissue formation and successfully treat skin lesions 冲击波的生物效应可以专门用来 生成新的身体细胞组织，治疗皮肤损伤
What are shock waves? Shock waves are high-energy acoustic waves that behave much like other sound waves except that they have much greater pressure and energy. As with sound waves, shock waves can travel great distances with ease as long as the acoustic impedance stays the same. However, when the acoustic impedance changes, energy is released and the greater the change in impedance the greater the release of energy. There is a much higher release of energy at a soft tissue/bone interface than at a muscle/fascia interface. The release of energy from the shock wave within the region of the affected tissues and the resultant compression and tension of cells creates a positive physiological effect. Mechano-transduction is the physiological effect thought to be responsible for stimulating normal and injured cells to produce healing factors.
What are the effects of shock waves? ESWT (Extracorporeal Shockwave Therapy) had various effects on bone and soft tissue. ESWT acts through mechanotransduction, which produces therapeutic benefits through complex biological pathways including neovascularization and tissue regeneration in the therapeutic target. Generally speaking, in sub-acute and chronic conditions, ESWT stimulates the re-initiation of stagnant healing processes, which causes re-modeling, and hence promotes healing, whereas in acute conditions, ESWT appears to initiate a more rapid and effective healing phase. increase blood supply to the treated area by stimulation of neovascularization and growth factors; influence on the expression of growth factors and -indicators such as e-NOS, TGF-ß, BMP, VEGF, PCNA; re-initiate stagnant healing processes in chronic injuries; decrease inflammatory processes; stimulate osteoclasts and fibroblasts to rebuild injured tissues; facilitate resorption of calcifications in tendons and ligaments; and stimulate migration (differentiation) of stem cells.
This is the first technology to provide: Promotion of growth Factors Promotion of Nitric Oxide Improves vascularity Promotion and migration and differentiation of stem cells Advantages of Softwave technology are: Treatments do not require anesthesia Larger surfaces such as wounds can be treated faster and easier with shockwave devices Units are smaller and much more economical to operate that “hardwave” technologies and traditional treatments Alleviates costly field service organizations to maintain Benefits of Softwave Technology
Shoulder Tendinopathies Case example: 2 sessions of shock wave therapy, a total of 1000 impulses were applied in 3 minutes. Recover in 12 weeks. 2 次治疗，每次 3 分钟，共 1000 次波击, 12 周恢复期
Achillodynia 跟腱炎 Case example: 2 sessions of shock wave therapy, a total of 1000 - 1500 impulses were applied in 3 minutes. Recover in 12 weeks. 2 次治疗，每次 3 分钟，共 1000 - 1500 次波击, 12 周恢复期
Greater trochanteric pain syndrome 股骨大转子疼痛综合征 Case example: 2 sessions of shock wave therapy, a total of 1000 - 2000 impulses were applied in 3 minutes. Recover in 12 weeks. 2 次治疗，每次 3 分钟，共 1000 - 2000 次波击, 12 周恢复期
Myofascial syndrome 肌筋膜综合征 Case example: 1 - 6 sessions of shock wave therapy, a total of 500 - 1000 impulses were applied in 3 minutes. Recover in 12 weeks. 1 – 6 次治疗，每次 3 分钟，共 500 - 1000 次波击, 每周一次， 12 周恢复期
Arthritis 风湿性关节炎 Case example: 6 - 12 sessions of shock wave therapy, a total of 100 0- 2000 impulses were applied in 3 minutes. Recover in 24 weeks. 6 – 12 次治疗，每次 3 分钟，共 1000 - 2000 次波击, 每周一次， 52 周恢复期
Post-operative healing disorders 手术后愈合困难 Case example: 2 sessions of shock wave therapy, a total of 1400 impulses were applied in 4 minutes and 40 seconds. 2 次治疗，每次 4 分又 40 秒，共 1400 次波击 17 weeks
Post-traumatic lesions 外伤口复合 Case example: dog bite, 4 sessions of shock wave therapy, a total of 3400 impulses were applied in 11 minutes and 20 seconds. 狗咬伤， 4 次治疗，共 11 分又 20 秒，共 3400 次冲击波 11 weeks
Venous ulcers 静脉溃疡 Case example: a venous ulcer at the lower limb persisting for many years, after 14 sessions of shock wave therapy with a total of 5500 impulses applied in 18 minutes and 20 seconds. 14 次的治疗，总共 18 分又 20 秒， 5500 次冲击波 1.5 years
Decubitus ulcers 褥疮溃疡 Case example: Weekly sessions were performed over a period of 6 months. 6 个月，每星期一次的治疗 2 years
Diabetic foot syndrome 糖尿病足综合症 Case example: 6 sessions of shock wave therapy using a total of 2300 impulses applied in 7 minutes and 40 seconds. 6 次治疗，总共 7 分又 40 秒， 2300 次冲击波 12 weeks
Arterial ulcer 动脉溃疡 Case example: after 2 sessions of shock wave therapy using a total of 900 impulses applied in 3 minutes. 2 次的治疗，共 3 分钟， 900 次的冲击波
Burns 烫伤 Case example: 4 times shock wave therapy with a total of 3000 impulses applied in 10 minutes of total treatment time. 4 次治疗，总共 10 分钟， 3000 次冲击波 7 weeks
Results after shock wave treatment Infection after dog bite Dermagold100 represents the first therapy system which specifically utilizes the biological effects of shock waves. In cooperation with TRT Tissue Regeneration Technologies LLC, USA, MTS opens up a new field of therapy for chronic wounds and skin lesions. The effectiveness of ESWT is fully proven for numerous indications. Recent research has shown that shock waves have highly beneficial effects on skin lesions. It is proven that tissue which is exposed to shock waves initiates the production of VEGF (vessel endothelial growth factor), which in turn activates the growth of new blood vessels. In addition, it has also been established that shock waves produce an antibacterial effect. The combination of these two effects initiates a healing process in skin lesions and stimulates the development of new tissue.
69 y, male – caught in a door (7 days after trauma) Result after 4 treatments / 4 week s (2300 impulses in total/ ~ 8 min.
52y, male (injury with lawn-mower); 4 weeks after injury 8Treatments (3000 pulses/ ~ 10min.) 4 weeks and 3 months after first ESWT treatment
71y, female, diabetic, polyneuropathy, ulcer for 2 months 6 treatments (4800 impulses in total / ~ 16 minutes) 4 months -> two surgical revisions
71y, female, diabetic, polyneuropathy, after two surgical revisions 5 treatments (2500 impulses in total / ~ 8 minutes) 2 months
86 y, female – infected hematoma (5 weeks after trauma), for 3 weeks no improvement, 4 treatments (1,600 pulses/ ~ 5min.) 5 weeks
8 days after burning injury 7 months later after 3 ESWT´s
82y, female (insulin dependent diabetes, chronic renal failure) 3 treatments ( 2300 pulses in total/~ 8 min.); 7 weeks after first ESWT; 3 treatments ( 2300 pulses in total/~ 8 min.); 7 weeks after first ESWT; 2 years follow-up 2 years follow-up
65 year old, male, fall over steps, HIV-positive, diabetic I° open tibia fracturesame day UTN
65 year old, male, fall over steps, HIV-positive, diabetic 3 months after trauma => ESWT3 months after ESWT3 years after ESWT
ProceduresProcedures Infection after trauma injury Results after shock wave treatment Procedures approved for dermagold100 Non-healing lesions Acute and chronic lesions Post traumatic lesions Post-operative healing disorders Procedures under current investigation Venous ulcers Arterial ulcers Decubitus ulcers Diabetic foot syndrome Burns
ProceduresProcedures Infection after trauma injury Results after shock wave treatment Procedures approved for dermagold100 Non-healing lesions 无法愈合的傷口 Acute and chronic lesions 急性，慢性皮肤病 Post traumatic lesions 外伤口 Post-operative healing disorders 手术后愈合困 难 Procedures under current investigation Venous ulcers 静脉溃疡 Arterial ulcers 动脉溃疡 Decubitus ulcers 褥疮 Diabetic foot syndrome 糖尿病足综合症 Burns 烧伤
Shock Waves - Application 1. Undertake wound debridement 2. Apply sterile ultrasound gel directly on the wound 3. Cover the wound with sterile foil 4. Apply further ultrasound gel on top of foil 5. Put applicator on top of foil and release spark waves whilst moving over wound area – number of spark waves depends on wound size and type 6. Apply appropriate dressing after treatment
Treatment Parameters Energy Flux density: ~ 0.1 mJ/mm 2 Frequency: 4-5 Hz Number of pulses: min.: 350 + 10/cm 2 Wound size Wound area number of pulses 1 x 1 cm 1 cm 2 350 + 10 = 360 2 x 2 cm 4 cm 2 350 + 40 = 390 2 x 4 cm 8 cm 2 350 + 80 = 430 4 x 5 cm 20 cm 2 350 + 200 = 550 6 x 8 cm 48 cm 2 350 + 480 = 830 10 x 12 cm 120 cm 2 350 + 1200 = 1550
Treatment Parameters Energy Flux density: ~ 0.1 mJ/mm 2 Frequency: 4-5 Hz Number of pulses: min.: 350 + 10/cm 2 伤口大小伤口面积脉冲次数 1 x 1 cm 1 cm 2 350 + 10 = 360 2 x 2 cm 4 cm 2 350 + 40 = 390 2 x 4 cm 8 cm 2 350 + 80 = 430 4 x 5 cm 20 cm 2 350 + 200 = 550 6 x 8 cm 48 cm 2 350 + 480 = 830 10 x 12 cm 120 cm 2 350 + 1200 = 1550
Director Director Combat Wound Initiative Program Complex Wound and Limb Salvage Center COL Alexander Stojadinovic, M.D., FACS
Combat Wound Initiative Program + Translation of fundamental research into individualized treatments for patients through: for patients through: Advanced therapies, Bioinformatics, Tissue Banking
Tissue regeneration – unfocused applicator The clinically tested unfocused applicator, an innovation of MTS & TRT group, emits unique and mainly unfocused shock waves that are specially designed for skin indications. To achieve optimal treatment results the energy volume and energy arrangement were accommodated for the treatment of skin lesions. Treatment without anesthesia The treatment does not require any anesthesia because the broad surface distribution of the optimal treatment energy with the Dermagold100 applicator significantly reduces the pain associated with shock wave treatment. The number of required treatments for each skin lesion varies, depending on the type of lesion and the wound surface.
Benefits by Category (cont) Benefits by Category (cont) Orthopedic, Arthritis and Joint Pain 骨科，关节炎，关节疼痛 每一年， 1-2 次治疗以后，减低 80% 的疼痛 25% 的病人有种疼痛 消除足底筋膜炎 治疗骨折 OTHER 其他 有效治疗创伤和需要皮肤移植的烧伤 冲击波大大加速上皮的形成 减少抗体药物的使用 ( 最高减低 7 倍 ) 有效治疗糖尿病造成的静脉溃疡
Benefits by Category (cont) Benefits by Category (cont) Orthopedic, Arthritis and Joint Pain Reduces up to 80% of pain with 1-2 treatments annually 25% of people have this affliction Eliminates Plantar Fascitius Treats non-unions OTHER Effective in treating traumas and burns requiring skin grafts Shock wave significantly accelerates donor site epithalization Reduces the need for anti-biotics (up to 7 times less) Effective treatment for diabetic and vascular ulcers
Reference from American Medical Association Journal The “patented unfocused software technology has the potential to become the new standard in wound care management” Leads to more rapid closure and repair of wounds on organs, skin and heart. Substantially lower cost and therapy time than current treatment standard Proven to increase permability of cell membranes Increased blood flow through angiogenesis Up regulation of growth factors Stem Cell Activation Beneficial to non-bacterial prostatitis (chronic pelvic pain syndrome) and cancer treatment.
Providers who can benefit from DermaGold TM Hospitals Cardiology Surgeons Orthopedics Surgeons Plastic Surgeons Sports Medicine Clinics Pain Management Clinics Podiatrists Chiropractors General Practices of Medicine Veterinarians Dentists
Providers who can benefit from DermaGold TM Hospitals 医院 Cardiology Surgeons 心脏外科 Orthopedics Surgeons 骨科医生 Plastic Surgeons 整形外科 Sports Medicine Clinics 运动医学诊所 Pain Management Clinics 疼痛管理诊所 Podiatrists 足病 Chiropractors 按摩师 General Practices of Medicine 全科医生 Veterinarians 兽医 Dentists 牙医
Product Lines Total product line is comprised of: LithoGold TM (lithotripsy) DermaGoldTM (wound care) OrthoGold 280 (orthopedics) CardioGoldTM (cardiovascular) VetGold (veterinary) Swisspuls (sports medicine, cosmetic and Veterinary medicine All Devices hold CE approval for international distribution and FDA approval is pending Devices are used in 30 countries including China, Japan, Taiwan and Russia Equipment is made with precision in Germany Warranty on material and workmanship for one year Maintenance after 100,000 pulses
Product Lines 产品系列 Total product line is comprised of: LithoGold TM (lithotripsy) 碎石 DermaGoldTM (wound care) 傷口治疗 OrthoGold 280 (orthopedics) 骨科 CardioGoldTM (cardiovascular) 心血管 VetGold (veterinary) 兽医 Swisspuls (sports medicine, cosmetic and Veterinary medicine 运动，美容 All Devices hold CE approval for international distribution and FDA approval is pending Devices are used in 30 countries including China, Japan, Taiwan and Russia 30 个使用国家，包括中国，日本，台湾，俄国 Equipment is made with precision in Germany 德国制做 Warranty on material and workmanship for one year 一年保证 Maintenance after 100,000 pulses 每 10 万次，需更换放射头
Technical Data 技术数据 Applicator OP155 Therapeutic Focus fz (-6dB):0 – 82 mm Energy Flux Density (ED): 0.01 – 0.19 mJ/mm2 Focus Energy (E total / -6dB): 0.40 – 3.88 mJ Dimensions: 21.8 x 40 x 45.9 cm Power Supply: AC 100 - 240 V, 50 - 60 Hz Power Input: 200 VA Repetition Rate: 0.5 - 8 Hz Weight: 16.5 kg dermagold100
ManagementManagement 美国生命能源控股公司是中国唯一的总代理 American Life Energy Holding Group, Inc. (“ALE”) is an exclusive distributor of softwave devices. Softwave devices 的 团队包挂诺贝尔奖得主, Dr. Ferid Murad. Distributorships available by contacting: 联系方式 American Life Energy Holding Group, Inc. 3091 Governors Lake Drive Building 100 Suite 500 Norcross, GA 30071 ， USA