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Current and future trends in industry Where academic life sciences research and education need to go Keith Yamamoto

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Presentation on theme: "Current and future trends in industry Where academic life sciences research and education need to go Keith Yamamoto"— Presentation transcript:

1 Current and future trends in industry Where academic life sciences research and education need to go Keith Yamamoto UCB Postdoc Industry Exploration Program September 27, 2012

2 Life sciences research at an inflection point data collection, detailed description data collection, detailed description quantitative understanding, solutions to big problems quantitative understanding, solutions to big problems How move through the inflection point? How move through the inflection point? Merge sciences: incorporate concepts and technologies of physics, chemistry, engineering, math, computer science Merge sciences: incorporate concepts and technologies of physics, chemistry, engineering, math, computer science Build working continuum: from fundamental discovery, to application, to addressing societal issues Build working continuum: from fundamental discovery, to application, to addressing societal issues It’s time to rethink life sciences research and education It’s time to rethink life sciences research and education

3 Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Challenges/Expectations for Research & Education Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science

4 Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Challenges/Expectations for Research Education Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science Training period much too long!

5 The Perilous, Slow Transition to Independence Median age, first independent position: 38 Median age, first independent position: 38 Median age, first R01: 42 Median age, first R01: 42 Percent NIH awards to new investigators: 4 Percent NIH awards to new investigators: 4 Einstein Nirenberg Cech Einstein Nirenberg Cech First Position: Nobel Prize: >> Need to train more efficiently: 4-8 years?

6 Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Challenges/Expectations for Research Education Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science Identify important problem Design experiments Select results for follow-up Identify important problem Design experiments Select results for follow-up

7 BSc BSc Postdoc Postdoc Independent Independent investigator investigator Academia, Biotech, Pharma Business Business Communication Communication Education Education Law Law Biotech startup Venture capital Science policy Intellectual property Patent Teaching Education Admin Journalism Information media A PhD “hub” with career option “spokes” PhD PhD

8 Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Challenges/Expectations for Research Education Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science

9 Mentored career exploration 10-week internships in business, law, communication, education, policy

10 BSc BSc Postdoc Postdoc Independent Independent investigator investigator Academia, Biotech, Pharma Business Business Communication Communication Education Education Law Law Biotech startup Venture capital Science policy Intellectual property Patent Teaching Education Admin Journalism Information media A PhD “hub” with career option “spokes” PhD PhD

11 Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Challenges/Expectations for Research Education Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science OR: Independent Fellows program Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science OR: Independent Fellows program

12 Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Challenges/Expectations for Research Education Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science

13 Build integrated, team-based research culture some UCSF approaches and experiments: -- BootCamps: 2 day intensive orientations -- Team Challenges: 4-5 day competitions -- Minicourses: 2.5 week immersion, team-based -- Design-science summer project -- UCSF PKU Team Challenge and an enabling tool: -- Knowledge network to integrate research approaches, data and investigators

14 Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Challenges/Expectations for Research Education Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science

15 Day science calls into play arguments that mesh like gears, results that have the force of certainty… Conscious of its progress, proud of its past, sure of its future, day science advances in light and glory. By contrast, night science wanders blind, it hesitates, stumbles, recoils, sweats, wakes with a start. Doubting everything, it is forever trying to find itself, question itself, pull itself back together. -Francois Jacob Night science is a sort of workshop of the possible, where what will become the building material of science is worked out. If at first the idea is not absurd, then there is no hope for it. - Albert Einstein

16 Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Mission/Goals for the PhD Specialized expertise Mentored, original, bold research Broad literacy and perspective Team-based research Math/statistics/computation skills Three “tools of the trade” Working familiarity with career options Future of academic research & education? Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science Mission/Goals for the Postdoc Progression to independent team-based research Management skills for the practice of science


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