1. Product Training Series
Cholestin®
Product Training Series
This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

2. New & Improved Cholestin®
Cholestin contains policosanol, a novel ingredient extracted from beeswax
Policosanol is clinically proven*
safe, effective, and well-tolerated
Proprietary PoliSorb™ † softgel delivery
Convenient once-a-day dosage
Pharmanex is first to market in the US
Pharmanex has exclusive rights for the network marketing channel
†Policor is a trademark of Hauser, Inc.

3. NCEP Cholesterol Guidelines
From: Third report of the National Cholesterol
Education Program Expert Panel, May 2001

4. NCEP Cholesterol Guidelines
Using NCEP guidelines,
about 65 million Americans
should make dietary and lifestyle changes
to maintain cardiovascular health

5. Cholestin® : Health Benefits
Maintains existing normal cholesterol levels*
Total & LDL-Cholesterol
HDL-Cholesterol
LDL/HDL Ratio
Triglycerides
Helps prevent oxidation of LDL cholesterol*
Promotes normal blood fluidity*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

6. History of Policosanol
Perez teams up with top-quality pharmaceutical company; now supplier
Early 90’s: Beeswax policosanol initially sourced in Cuba
Sugarcane policosanol clinically tested and commercialized in Cuba
Mid 90’s: Sugar cane policosanol suggested as more economical source Cuban government
Pedro P. Perez revives R&D work in US for beeswax policosanol
2001: Pharmanex launches Cholestin® - beeswax policosanol

7. Cholestin Composition
Primary Active Constituent:
Policosanol from Beeswax (PolicorTM )†
Novel ingredient - “Cholesterol Breakthrough”
Extracted from white NF-grade beeswax (GRAS)
Patent granted to supplier in October (for use, composition and process)
Pharmanex has been granted exclusivity for Network Marketing Channel
†Policor is a trademark of Hauser, Inc.

8. Standardization Guaranteed minimum 40% policosanol
Reproducible fingerprint of 5 primary aliphatic long-chain alcohols

9. PoliSorb™ † Proprietary Delivery
PoliSorb softgels have over 10 times better dissolution than policosanol capsules or tablets
Policosanol delivery can be problematic:
naturally a fat-soluble, waxy substance
remains solid at body temperature
tablets & capsules have poor dissolution
Pharmanex PoliSorb™ proprietary delivery:
overcomes solubility problems
emulsified with lecithin phospholipids
natural cell membrane components
†Policor is a trademark of Hauser, Inc.

10. Policosanol: Clinical Data
Policosanol (sugar cane wax), double-blind clinical trials:**
Blood lipids: 13 studies (total of 1,378 subjects)
Platelet aggregation: 6 studies
LDL-oxidation: 1 study
Policosanol from beeswax may be more effective:
Main constituent in sugar cane wax, octacosanol, is not very active in rats (Kato S, Br J Nutr 1995;73:433)
Beeswax policosanol clinical trials:
Two open-label pilot studies
* Summarized in Healthcare Professionals Product Guide

11. Clinical Data - Summary
Research with policosanol has shown the following results (10-20 mg/day):*
Benefits after 8-12 weeks, maximum effect evident after 12 months
Excellent safety & side effect profile
* Summarized in Healthcare Professionals Product Guide

12. Policosanol Safety Beeswax policosanol has excellent safety data:
Clinical data: few & mild side effects*
Made from purified, white NF-grade beeswax
GRAS (FDA-Approved) for food & drug use
* Summarized in Healthcare Professionals Product Guide

13. Drug Interactions No clinical reports of drug interactions*
Preliminary contraindications:
high-dose aspirin therapy
anticoagulants (warfarin, coumadin, etc.)
discontinue within 2 weeks of surgery
* Summarized in Healthcare Professionals Product Guide

14. Summary Cholestin maintains existing normal cholesterol levels*
Provides 15 mg per softgel of policosanol
Policosanol is clinically proven
Proprietary PoliSorb™ softgel delivery
Convenient once-a-day dosage
Safe & well tolerated
Pharmanex is first to market in the US
Pharmanex has exclusive rights for the network marketing channel
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.