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Micro- & Nanoencapsulation Services

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Presentation on theme: "Micro- & Nanoencapsulation Services"— Presentation transcript:

1 Micro- & Nanoencapsulation Services

2 Presentation About us Micro- & Nanoencapsulation Services
Catalan Institute of Nanotechnology Supramolecular NanoChemistry & Materials Group Micro- & Nanoencapsulation Services Presentation About us

3 Catalan Institute of Nanotechnology (ICN)
The Catalan Institute of Nanotechnology (ICN) is a non-profit private foundation created in 2003 by the Ministry of Universities, Research and Information Society of the Catalan Government (DIUE) and the Autonomous University of Barcelona (UAB). It is part of CERCA, the network of Research Centres launched by the Catalan Government as a cornerstone of its long-term strategy to foster development of a knowledge-based economy. ICN's research lines focus on the newly discovered physical and chemical properties that arise from the fascinating behaviour of matter at the nanoscale.

4 Supramolecular NanoChemistry & Materials
The Supramolecular NanoChemistry & Materials (NANOup) group was set up in 2009 by ICREA Research Prof Daniel Maspoch. It comprises 5 senior researchers, 6 PhD students and 1 project manager. NANOup uses supramolecular chemistry to explore new materials and applications (in close collaboration with several private companies) in diverse areas, including micro- and nanoencapsulation, drug-delivery systems, contrast agents, and novel sensors and magnetic platforms.

5 NANOup team ICREA Prof. Daniel Maspoch Group Leader Dr. Inhar Imaz
RyC Researcher Dr. Mary Cano Researcher Dr. Kyriakos Stylianou Marie Curie Fellow Dr. Sonia García Contracted Post-Doc Dr. Nereida Mejías Senior Technician Marta González Project Manager Marta Rubio ICN Fellow Carlos Carbonell Contracted PhD Àngels Ruyra Ramón Areces Fellow Iván Burneo SENESCYT Fellow Arnau Carné FI Fellow Javier Ariñez FPU Fellow

6 Research Lines Basic Research Micro- and Nano- encapsulation Services
Nanoscale Supramolecular Materials Supramolecular Nanostructures on Surfaces Micro- and Nano- encapsulation Services Micro- and Nanoencapsulation Technologies

7 Micro- and Nanoencapsulation Technologies
Packaging micro- or nanoparticles of solid, liquid or gas (the core or active substance) within a secondary material (the matrix or shell), to form nano- or microcapsules The core material is protected by a shell and only delivered when needed. Triggered release (pH, T, pressure) Target release (site recognition) Sustained release (shell decomposition)

8 Functional advantages
Protect core material Change properties (increase solubility, mask taste, etc.) Aesthetic improvements Decrease toxicity (reduce required dose; local release) Reduce costs

9 product development Micro- & Nanoencapsulation Services Our mission:
To help private companies and public research institutes to develop novel encapsulation products we provide a complete product development service

10 From the lab to the market:
We design and fabricate new products, based on in-house technology, and assist collaborators with scaling-up. Design Development Quality Control Scale-up to Commercial Quantitites

11 Our expertise We have developed diverse types of micro- and nanocapsules to match each industrial sector and application. These differ by their membrane, which is carefully selected to suit the customer’s needs. Depending on the final application, the membrane can be further optimised. Core Hydrophobic liquids Aqueous solutions Solids Emulsions Dispersions Gases Shell Polymers: natural (polysaccharides, proteins, etc.), synthetic (polyamides, polyesters, polyureas, polyurethanes, urea/melamine-formaldehyde resin, polystyrene, etc.), semi synthetic (chitosan, cellulose, starch, etc.) Lipids: cholesterol, phospholipids Inorganic materials: SiO2

12 Modify properties of the core material
Prevent environmental oxidation or deactivation Separate incompatible materials Protect core material Mask organoleptic properties like color, taste, odor of substances Safe handling of toxic cores Modify properties of the core material Reduce handling costs Convert liquids to free- flowing solids Improve adhesion, penetration or recognition of tissues and cells Reduce active doses, and therefore, potential toxicity/side-effects Controlled and targeted release of encapsulated cores Provide sustained release  maintain optimal concentration Provide triggered release based on environmental changes (T, pH) Marketing & product aesthetics Modify core material via release Enable more stable, efficient and biocompatible products, based on nanocapsules Develop novel products

13 Our capabilities We can encapsulate core materials in different polymer membranes. Encapsulation protects the active component in the core, enables controlled release and reduces or eliminates toxicity. +

14 In-situ, interfacial & radical polymerisation
Melamine-formaldehyde, polyurethane, styrene, polyurea, polyamides, polyesters, silica, ethylcellulose Simple and complex coacervation Gelatin, acacia and glutaraldehyde Casein, chitosan, PVA Liposomes & Solid Lipid Nanoparticles Lipid-cake hydration and homogeneisation by extrusion, ultrasound Emulsions Nanoemulsions, double emulsions Polymeric surfactants Spray-drying Particle miniaturisation (300 nm to 100µm) Encapsulate peptides, drugs or food ingredients

15 Our equipment Through specialised facilities—some of which are unique in Spain—we offer high-level technical assistance to collaborate with external partners, including for commercial R&D. Equipment for synthesis Pilot plant Characterisation

16 Nanochemistry Lab Spray-drying Extrusion
Rotary evaporator Freezer (-80 ºC) Lyophiliser Ultracentrifuge Spray-drying Nanospray Spray Drier (Büchi) Mini Spray Drier (Büchi) Particle miniaturisation Extrusion LIPEXTM extruder (Northern Lipids) Liposome preparation at 10 mL scale

17 High pressure homogenisation
Bench scale mixers Overhead stirrers Ultraturrax (IKA) Ultrasound probe High pressure homogenisation M-110L Microfluidiser Processor High-shear fluids processing Microfluidics Pilot plant reactor Dispermat CN 0.5 to 40 L Dissolver

18 deformability studies Size determination Porosity studies
Full chemical characterisation IR, UV, Elemental analysis, EDX, TOF-SIMS, X-ray powder diffraction Full physical characterisation Viscosimeter Study of the release 4 mm Direct Visualisation SEM TEM Cryo-TEM Stability studies Turbiscan Mastersizer Rupture force & deformability studies Nanoindentator Size determination DLS SEM Porosity studies BET

19 Custom solutions With extensive experience and knowledge in the microencapsulation field, we can solve your technical problems in any industrial sector. We can help you to protect solid particles or liquid droplets and ensure controlled release of the active components. 

20 Textiles Nutrition Drugs Construction Cosmetics Agriculture Nanotechnology does not always involve expensive equipment or rare materials: it can often be incorporated into existing industrial processes with minimal capital investment.

21 We are already working with several companies to develop new commercial products and techniques that incorporate Nanotechnology: Fragrance encapsulation for detergents and softeners Biocide encapsulation for paintings Disinfectant encapsulation for clinical surfaces disinfection Enzymatic encapsulation Peptide micronisation Capsules for self-repairing wood Development of encapsulating matrices using metal-organic systems Encapsulation of phage & inmunostimulants in liposomes and in polysaccharide & biocompatible polymers

22 Questions on encapsulation? Feel free to contact us!
Thank you for your attention! Group Leader, NANOUP Micro- and Nanoencapsulation Technologies Leader, NANOUP

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