2 Presentation About us Micro- & Nanoencapsulation Services Catalan Institute of NanotechnologySupramolecular NanoChemistry & Materials GroupMicro- & Nanoencapsulation ServicesPresentationAbout us
3 Catalan Institute of Nanotechnology (ICN) The Catalan Institute of Nanotechnology (ICN) is a non-profit private foundation created in 2003 by the Ministry of Universities, Research and Information Society of the Catalan Government (DIUE) and the Autonomous University of Barcelona (UAB). It is part of CERCA, the network of Research Centres launched by the Catalan Government as a cornerstone of its long-term strategy to foster development of a knowledge-based economy.ICN's research lines focus on the newly discovered physical and chemical properties that arise from the fascinating behaviour of matter at the nanoscale.
4 Supramolecular NanoChemistry & Materials The Supramolecular NanoChemistry & Materials (NANOup) group was set up in 2009 by ICREA Research Prof Daniel Maspoch. It comprises 5 senior researchers, 6 PhD students and 1 project manager.NANOup uses supramolecular chemistry to explore new materials and applications (in close collaboration with several private companies) in diverse areas, including micro- and nanoencapsulation, drug-delivery systems, contrast agents, and novel sensors and magnetic platforms.
5 NANOup team ICREA Prof. Daniel Maspoch Group Leader Dr. Inhar Imaz RyC ResearcherDr. Mary CanoResearcherDr. Kyriakos StylianouMarie Curie FellowDr. Sonia GarcíaContracted Post-DocDr. Nereida MejíasSenior TechnicianMarta GonzálezProject ManagerMarta RubioICN FellowCarlos CarbonellContracted PhDÀngels RuyraRamón ArecesFellowIván BurneoSENESCYT FellowArnau CarnéFI FellowJavier AriñezFPU Fellow
6 Research Lines Basic Research Micro- and Nano- encapsulation Services Nanoscale Supramolecular MaterialsSupramolecular Nanostructures on SurfacesMicro- and Nano-encapsulationServicesMicro- and Nanoencapsulation Technologies
7 Micro- and Nanoencapsulation Technologies Packaging micro- or nanoparticles of solid, liquid or gas (the core or active substance) within a secondary material (the matrix or shell), to form nano- or microcapsulesThe core material is protected by ashell and only delivered when needed.Triggered release (pH, T, pressure)Target release (site recognition)Sustained release (shell decomposition)
9 product development Micro- & Nanoencapsulation Services Our mission: To help private companies and public research institutes to develop novel encapsulation productswe provide a completeproduct developmentservice
10 From the lab to the market: We design and fabricate new products, based on in-house technology, and assist collaborators with scaling-up.DesignDevelopmentQuality ControlScale-up toCommercialQuantitites
11 Our expertiseWe have developed diverse types of micro- and nanocapsules to match each industrial sector and application. These differ by their membrane, which is carefully selected to suit the customer’s needs. Depending on the final application, the membrane can be further optimised.CoreHydrophobic liquidsAqueous solutionsSolidsEmulsionsDispersionsGasesShellPolymers:natural (polysaccharides, proteins, etc.),synthetic (polyamides, polyesters, polyureas, polyurethanes, urea/melamine-formaldehyde resin, polystyrene, etc.),semi synthetic (chitosan, cellulose, starch, etc.)Lipids: cholesterol, phospholipidsInorganic materials: SiO2
12 Modify properties of the core material Prevent environmental oxidation or deactivationSeparate incompatible materialsProtect core materialMask organoleptic properties like color, taste, odor of substancesSafe handling of toxic coresModify properties of the core materialReduce handling costsConvert liquids to free- flowing solidsImprove adhesion, penetration or recognition of tissues and cellsReduce active doses, and therefore, potential toxicity/side-effectsControlled and targeted release of encapsulated coresProvide sustained release maintain optimal concentrationProvide triggered release based on environmental changes (T, pH)Marketing & product aestheticsModify core material via releaseEnable more stable, efficient and biocompatible products, based on nanocapsulesDevelop novel products
13 Our capabilitiesWe can encapsulate core materials in different polymer membranes. Encapsulation protects the active component in the core, enables controlled release and reduces or eliminates toxicity.+
14 In-situ, interfacial & radical polymerisation Melamine-formaldehyde, polyurethane, styrene, polyurea, polyamides, polyesters, silica, ethylcelluloseSimple and complex coacervationGelatin, acacia and glutaraldehydeCasein, chitosan, PVALiposomes & Solid Lipid NanoparticlesLipid-cake hydration and homogeneisation by extrusion, ultrasoundEmulsionsNanoemulsions, double emulsionsPolymeric surfactantsSpray-dryingParticle miniaturisation (300 nm to 100µm)Encapsulate peptides, drugs or food ingredients
15 Our equipmentThrough specialised facilities—some of which are unique in Spain—we offer high-level technical assistance to collaborate with external partners, including for commercial R&D.Equipment for synthesisPilot plantCharacterisation
18 deformability studies Size determination Porosity studies Full chemicalcharacterisationIR, UV, Elemental analysis,EDX, TOF-SIMS,X-ray powder diffractionFull physicalcharacterisationViscosimeterStudy of the release4 mmDirectVisualisationSEMTEMCryo-TEMStability studiesTurbiscanMastersizerRupture force &deformability studiesNanoindentatorSize determinationDLSSEMPorosity studiesBET
19 Custom solutionsWith extensive experience and knowledge in the microencapsulation field, we can solve your technical problems in any industrial sector.We can help you to protect solid particles or liquid droplets and ensure controlled release of the active components.
20 TextilesNutritionDrugsConstructionCosmeticsAgricultureNanotechnology does not always involve expensive equipment or rare materials: it can often be incorporated into existing industrial processes with minimal capital investment.
21 We are already working with several companies to develop new commercial products and techniques that incorporate Nanotechnology:Fragrance encapsulation for detergents and softenersBiocide encapsulation for paintingsDisinfectant encapsulation for clinical surfaces disinfectionEnzymatic encapsulationPeptide micronisationCapsules for self-repairing woodDevelopment of encapsulating matrices using metal-organic systemsEncapsulation of phage & inmunostimulants in liposomes and in polysaccharide & biocompatible polymers
22 Questions on encapsulation? Feel free to contact us! Thank you for your attention!Group Leader, NANOUPMicro- and Nanoencapsulation Technologies Leader, NANOUP