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Reversing The Trend Radiochemistry at the University of Missouri-Columbia J. David Robertson Silvia Jurisson Susan Lever Department of Chemistry, University.

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Presentation on theme: "Reversing The Trend Radiochemistry at the University of Missouri-Columbia J. David Robertson Silvia Jurisson Susan Lever Department of Chemistry, University."— Presentation transcript:

1 Reversing The Trend Radiochemistry at the University of Missouri-Columbia J. David Robertson Silvia Jurisson Susan Lever Department of Chemistry, University of Missouri Columbia, MO 65211

2 Data courtesy of S.B. Clark, Washington State University 1 Radiochemist per Department Below “critical mass” Reversing the Trend: University of Missouri Radiochemistry

3 1978 Report of the Ad Hoc Committee on Training of Nuclear and Radiochemists, Division of Nuclear Chemistry and Technology, American Chemical Society Surveyed the status and future needs and supplies of manpower in nuclear and radiochemistry in the U.S. 1.The numbers of nuclear and radiochemistry faculty members were decreasing 2.There were few practicing radiochemists 3.Negative public perception had led to student reluctance to enter the field 4.The supply of students trained in these and related areas fell far short of meeting the projected national needs

4 Workshop on Training Requirements for Chemists in Nuclear Medicine, Nuclear Industry, and Related Areas National Academy Press, Washington, D.C. 1988. Participants from academic institutions, national laboratories, the nuclear power industry, the nuclear medicine community, the pharmaceutical industry, and government. Each panel concluded: 1.There was a serious shortage of chemists with a background in nuclear and radiochemistry 2.There was a serious shortage of bona fide nuclear and radiochemists

5 The Education and Training of Isotope Experts A study for the Subcommittee on Energy and Environment of The Committee on Science of the U.S. House of Representatives, Members of the Senior Scientists and Engineers of the American Association for the Advancement of Science, 1998 Study found “no recovery from the very serious diminution of the U.S. educational capability in isotope science and technology.” From the 30 institutions in nuclear and radiochemistry responding to their survey, the data for numbers of graduates and numbers of fulltime faculty showed no improvement from the previous 1987 survey.

6 2007 NAS Report Advancing Nuclear Medicine Through Innovation Shortage of individuals being trained in radiochemistry and radiopharmaceutical chemistry Journal of Nuclear Medicine 43:11N, 2002. “while the spectacular benefits of nuclear and molecular imaging and targeted radiotherapy have long been recognized and are becoming more commonplace, there is a major inadequacy of supply of radiochemists and radiopharmacists to meet the ever increasing demands in the U.S. and around the world.”

7 Chemistry Department Radiochemistry Program 3 Chemistry Faculty –Silvia Jurisson—inorganic/radiochemistry –Susan Lever—organic/radiopharmaceutical chemistry –Dave Robertson—radioanalytical/nuclear chemistry Radiochemistry Courses at MU –Introduction to Radiochemistry (with lab) 35 to 45 students each year Chemistry, Nuclear Engineering, Nuclear Medicine –Advanced Radiochemistry –Nuclear Chemistry –Radiopharmaceutical Chemistry –Radiopharmaceuticals in Nuclear Medicine –Radiation Biology

8 University of Missouri MS and PhD Radiochemistry Students 26 PhD Graduates in Radiochemistry (1995 – 2007) –10 US Citizens –Academia, Industry, National Labs 8 MS Graduates in Radiochemistry (1995 – 2007) –3 US Citizens –Industry 20 Current Radiochemistry Graduate Students –13 US Citizens

9 University of Missouri MS and PhD Radiochemistry Students REAP students: Dr. Paul Benny, Washington State University Dr. Jim Gawenis, University of Utah Dr. Leah Arrigo, SRNL Staff Scientist NSF graduate fellow: Dr. Rachel Popelka, NRC Postdoc at NIST

10 NIBIB Graduate Training (NIH T32) in Radiopharmaceutical Chemistry at University of Missouri (2007-2012) Chemistry Department University of Missouri Silvia Jurisson (PI) Susan Lever (Co-PI) Martin Brechbiel (site PI) Internships at the NCI or BNL Joanna Fowler (site PI)

11 Radiochemistry NSF REU 04 - 07 REU Program 5 students in S04, 10-12 students S05-S07 No Previous Exposure Weekly radiochemistry lecture Weekly literature discussion

12 Interdisciplinary Radiochemistry at the University of Missouri 10 MW University of Missouri Research Reactor (MURR) 16.8 MeV Cyclotron Facility Radiopharmaceutical Science Institute Nuclear Science and Engineering Institute

13 Initial criticality was attained on October 13, 1966. Designed and constructed to operate at 5 megawatts, the facility was upgraded to 10 megawatts in 1974. 6.5 day per week operation. The compact core is surrounded by beryllium and graphite reflectors: Isotope Production Radiopharmaceutical Radioanalytical Archaeometry Epidemiology Environmental Science University of Missouri Research Reactor (MURR)

14 16 th Bi-annual SSAC course Rebecca Stevens (LANL, Director) Douglas E. Berning (LANL, Co-director) J. David Robertson (University of Missouri – Columbia) John Gahl (University of Missouri – Columbia) Michael Flagg (University of Missouri – Columbia) John McClelland-Kerr (Department of Energy) Vladimir Cisar (International Atomic Energy Agency) May 20 th – June 1 st 2007 Columbia, MO Directed by Los Alamos National Laboratory Hosted by the University of Missouri – Columbia and the Missouri University Research Reactor (MURR) Sponsored by the IAEA, Department of Energy, and Department of State 39 participants from 33 countries attended the course

15 State Systems of Accounting for and Control of Nuclear Materials Goal: – Provide participants with an in-depth understanding of the requirements of a state in fulfilling its international safeguards obligations Objectives: – Demonstrated safeguards concepts Lectures, workshops, and visits to model facility (MURR) Question and answer session with panel group –Panel group was comprised of personnel from countries with established SSAC programs

16 SSAC Group Photos

17 Nuclear Science and Engineering Institute (NSEI) Core Faculty Bill Miller Sudarshan Loyolka Mark Prelas Tushar Ghosh Bill Thompson Wynn Volkert (Joint) Dave Robertson (Joint) Silvia Jurisson (Joint) Mike Glascock (Joint) John Gahl (Joint) Department Nuclear Engineering Radiology Chemistry MURR Electrical Engineering

18 Nuclear Energy Technology NETwork Center Dr. William Miller, NSEI & MURR Randy Etter, Gayla Neumeyer, MURR Radiation Protection Technician program DOL grant 79 students enrolled at ATC/Linn State Program partners AZ, CA, VA, TX Nuclear Quality Control Technician program NRC grant F08


20 UMC Medical School – Dept. of Internal Medicine Division of Hematology & Medical Oncology Michael C. Perry, M.D., FACP Timothy J. Hoffman, Ph.D. Carolyn J. Henry, D.V.M.** Yubin Miao, Ph.D.* Lixin Ma, Ph.D* Research Oncologist (New Recruit) Scientific Collaboration Overview Radiopharmaceutical Sciences Institute *Primary Appointment **Joint Appointment UMC Medical School Dept. of Radiology Wynn R. Volkert, Ph.D.* Thomas P. Quinn, Ph.D.** Kattesh V. Katti, Ph.D.** John R. Lever, Ph.D.** Jeff Smith, Ph.D** Bennett S. Greenspan, M.D. Amolak Singh, M.D. U.S. Dept. of Veterans Affairs H.S. Truman Memorial VA Hospital Wynn A. Volkert, Ph.D. Timothy J. Hoffman, Ph.D.* Susan L. Deutscher, Ph.D. Michael R. Lewis, Ph.D. John R. Lever, Ph.D. Leonard R. Forte, Ph.D.* Thomas P. Dresser, M.D. Jeff Smith, Ph.D. Yubin Miao, Ph.D. Vladislav Glinskii, M.D. Ed Sauter, M.D. Silvia Jurisson, Ph.D. UMC College of Veterinary Medicine Michael R. Lewis, Ph.D.* Carolyn J. Henry, D.V.M.* Jimmy C. Lattimer, D.V.M. UMC Medical School Dept. of Biochemistry Thomas P. Quinn, Ph.D.* Susan L. Deutscher, Ph.D.* Wynn A. Volkert, Ph.D.** Vladislav Glinskii, M.D.* Yubin Miao, Ph.D.** UMC – College of Arts & Science Dept. of Chemistry Silvia S. Jurisson, Ph.D. Susan Z. Lever, Ph.D.** Wynn A. Volkert, Ph.D.** MU Research Reactor Center Alan R. Ketring, Ph.D. Cathy Cutler, Ph.D. Gary Ehrhardt, Ph.D. Kattesh V. Katti, Ph.D.** Susan Z. Lever, Ph.D,** Jeff Smith, Ph.D.** UMC Medical Physiology & Pharmacology Leonard R. Forte, Ph.D.* John Lever** TJH-4/2004 Faculty and Scientists Currently Funded or Actively Collaborating in Radiopharmaceutical Research UMC Dept. of Surgery Ed Sauter, M.D.*

21 The 2008 Survey of Graduate Education and Manpower Needs in Nuclear and Radiochemistry?

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