Presentation on theme: "New Delivery Systems from Dow Corning December 2005."— Presentation transcript:
New Delivery Systems from Dow Corning December 2005
Desired result: 3 take-aways Why Dow Corning is committed to providing you with the broadest range of delivery system technologies Our existing technologies, our resources to customize solutions that meet your formulating needs exactly, and where we’ll continue to invest The strength of our in-house experts and alliance partners
Agenda Strategic insight into the Life Sciences business Deliver the Difference — the vision for our delivery systems technologies portfolio Technical overview Phospholipid-based Vesicles Silicone Vesicles Micro-encapsulation Silicone Elastomer Blends
Strategic Insight Our Life Science’s vision is to improve the quality of life in the markets we serve Our mission is to be your ideal supplier of performance enhancing materials — including those that deliver active ingredients Our objective is to collect and offer various, diverse delivery technologies
Strategic Insight Our strategy is highly integrated and includes but is not limited to: - Relying on our 60+ year heritage designing and formulating functional specialty chemicals - Exploiting our global supply chain that reliably delivers the highest quality material - Leveraging our strong customer relationships to collaborate and innovate custom solutions-
The Benefit to You “ One stop” shopping — materials, technical support, formulating expertise, application knowledge, EHS documentation, analytical services, performance testing capabilities, customized solutions on a global scale A broader choice of ingredients that — in combination with silicones — promote synergistic performance benefits
Next steps Developing a delivery systems technologies portfolio is a journey, not a destination!
Deliver the Difference
Why Delivery Systems The market’s growing at a double digit rate Consumers demand convenience (multifunctionality), healthful/youthful appearance (well being), natural ingredients (vitamins, botanicals) and environmental protection (antioxidants, UV/sun blocks) — active ingredients can meet these expectations Delivery technologies are formulation specific — few suppliers are consolidating multiple technologies under one offering
Alliances and Partnerships Silicone-based technologies have some intrinsic limitations and cannot meet all of the key market needs by themselves In order to fulfill our vision of a global, world-class delivery systems provider we sought leading edge technology partners to fill the gap Lipo Chemicals, Inc. and Lipo Technologies, Inc. and Dow Corning have formed an alliance to offer micro- encapsulation technologies as part of our offering
Deliver the Difference Succeeding in the marketplace is largely contingent on providing a solution to an already unmet need or differentiating your solution from the competition Dow Corning and our partners understand this — therefore working to provide a total solutions offering around delivery When it comes to delivering a different kind of product, we hope you’ll think of Dow Corning as a different kind of partner — one that can help you…Deliver the Difference
Delivery Systems Portfolio
Introducing Four Delivery Technologies Introducing Four Delivery Technologies Phospholipid-based Vesicles Silicone Vesicles Micro- and milli- encapsulation Systems Silicone Elastomer Blends
Combined effect of a high level of phosphatidylcholine and high level of dilinoleoylphosphatidylcholine Soy bean lecithin = GMO free Unilamellar liposomes Physical and chemical stability Penetration of the upper layers of skin Innovative testing capabilities to prove vitamin stability, efficacy and penetration (ESR)
Dow Corning ® Liposomes Penetrating Liposome System Penetrating line designed to supply cosmetic actives in the upper layers of the skin Non-Penetrating Liposome System Non-Penetrating line designed to supply cosmetic actives on the surface of the skin Penetration is prevented by the use of a sterically hindered triglyceride Commercially available loaded with a variety of cosmetic actives with the possibility for customization
Dow Corning® Silicone Vesicles
Silicone vesicles are hollow particles with water at the exterior and interior, and a bilayer that contains the particle. Capable of encapsulating both lipophilic and hydrophilic actives. New “assembly-required” vesicles developed with attractive morphologies.
Dow Corning® Silicone Vesicles Dow Corning® Silicone Vesicles Two silicone vesicles are currently under development based on: rake SPE (AB)n SPE Actives encapsulated: Vitamins (vitamin A palmitate, vitamin C) Sunscreens, and Fragrances. Stability of Si vesicle encapsulated actives demonstrated. Encapsulation of customer’s specific actives possible.
Micro- and Milli- encapsulation Systems
Gelatin Lipocapsules ® Animal Derived (Gelatin) CMC – Gum Arabic- Carrgeenan microns average diameter 50 – 97% Internal phase PMU Lipocapsules ® Synthetic Derived Polyoxymethylene Urea Methoxymethyl Methylol Melamine 5 –100 microns average diameter 50-80% Internal Phase Limitations Water insoluble IP only Soften at pH 8.5 and higher Permeable to solvents Residue after rupture No dry over 500 microns Filling requirements Limitations Water insoluble IP only Soften at pH 8.5 and higher Fragile at sizes > 100 microns Residue after rupture Filling requirements Advantages Separation of Incompatibles Target or Sustained Release Prevent Oxidation Improve Flow Characteristics Convert Liquids to Solids Improved Aesthetics Supplied slurry, cake or dry powder Lipocapsules ®
Lipospheres ® Gellan Heteropolysaccharide microns 25% Internal Phase Alginate Calcium Alginate microns 25% Internal PhaseAgar Polysaccharide 500 – 400 microns 25% Internal Phase Limitations Solvent permeable Slurry only Filling requirements Limitations Solvent permeable Slurry only Reversible reaction Filling requirements Limitations Solvent permeable Slurry only Filling requirements Advantages Vegetable derived Water soluble IP capable Water insoluble IP capable No residue after rupture Target or sustained release Improved aesthetics
Lipobead™ Vegetable Derived Mannitol Cellulose HPMC 700 & 1500 microns Average 5% Internal Phase Animal Derived Lactose Cellulose HPMC 700 & 1500 microns Average 5% Internal Phase Limitations Solvent Permeable Advantages Water soluble IP capable Water insoluble IP capable Supplied as dry prills Extended hydration time No residual after rupture Target or sustained release Improved aesthetics
Lipoparticle™ Vegetable Derived Cellulose Cyclodextrins Microns Average 30% Internal PhaseSynthetic Nylon Microns Average 30% Internal Phase Limitations Solvent Permeable Dispersion considerations Advantages Water soluble IP capable Water insoluble IP capable Convert liquids to solids Substrate for overcoat Substrate for granulation Target or sustained release Improve flow characteristics
Dow Corning® Silicone Elastomer Blends
A crosslinked silicone elastomer gel particle swollen in various cosmetic fluids. The unique fluid-in-gel particle offers a very desirable smooth, silky skin feel. Soft gel particles of 20 – 80 um size. Two options to incorporate actives: Post-loading: Pre-loading: Dow Corning® Silicone Elastomer Blends
Actives investigated: vitamins, fragrances and sunscreens. Stability in both pre- and post-loaded SEBs and cosmetic formulations. Excellent skin sensory feel retained in active-entrapped SEBs.