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Session 3 Peer Support Quiz
Ligands that activate a pathway are called?
Agonists Oppositely, ligands that deactivate a pathway are called antagonists
How many subunits in a G-protein?
Three Alpha α Beta β Gamma γ
Name the 3 doctor-patient relationships.
Paternalistic Shared Informed
Saliva is produced from which cells?
What are the 4 main definitions of health?
Health is absence of illness - -ve Health is functional ability - -ve Health is freedom - +ve Health is equilibrium- +ve
Nitric oxide works with guanylate cyclase through which cyclic nucleotide?
G-proteins are switched ‘ON’ when bound to GDP. True or False
False G-proteins must be bound to GTP to be active
What are the 4 roles of saliva?
Solvent Lubrication Digestion Protection
What are the 4 main stages in the signalling cascade for growth factors (GF)?
Binding of GF stimulates dimerisation of receptors Phosphorylation of receptors Ras and adaptor bind Ras GDP GTP nucleotide exchange
What is the typical ion concentration of potassium K+ inside and outside the cell?
Inside = 160mM Outside = 5mM
Inhibitory growth factor IGF works through which target proteins?
Chronic illness can impact on a persons life in which 4 ways?
Daily living Social relationships Identity (how others view them) Sense of self (how they view themselves)
Saliva excretion is controlled by which nervous system?
DFLE stands for? (in the context of life expectancy)
Disease free life expectancy
Name the 3 phases of swallowing?
Oral Pharyngeal Oesophageal
How can you measure socio-economic status?
Occupation Education Ownership/access to assets
Name 5 originations of lay beliefs.
Personal knowledge or experience Previous encounters Folk knowledge Media/internet Spiritual beliefs Alternative and complementary medicine
What 3 mechanisms can change cell behaviour?
Gene transcription Altered ion balance across the plasma membrane Altered activity/level of pre-existing enzymes
Is the lower oesophageal sphincter a true sphincter or a physiological one?
Give 3 outcomes of shared decision making.
Improve patient outcome Reduction in costs Increased patient satisfaction
PLC hydrolyses PIP2 to what?
IP3 and DAG
What are the 5 triggers for seeking medical help?
Interpersonal crisis Interference with social or personal relationships Sanctioning Interference with vocational or physical activity Temporalisation of symptomatology
List the 5 types of receptor.
Intracellular Ion channel Intrinsic enzyme activity Soluble protein kinase Linked to a G-protein
What are the concentrations of Ca2+ ions inside and outside of the cell?
Inside = 0.2μM Outside = 2mM Remember – its an increase in concentration of x10,000
For a nucleotide to be a second messenger, it must be in a cyclic form. True or false
Receptors and Signalling. Types of receptors... 1.Ion channels 2.Intracellular 3.Intrinsic enzyme activity 4.Soluble protein kinases 5.G-protein linked.
B. Signal Transduction Pathway (cell signaling) 1. Process by which a signal on a cell surface is converted into a specific cellular response Multistep.
You Must Know 3 stages of cell communication Reception, transduction, & response How G-protein-coupled receptors receive cell signals & start transduction.
Chapter 11 Cell Communication. Cell communication signal cells communicate by direct contact or by secreting local regulators ex: growth factors, neurotransmitters.
Cell Communication Chapter 11:. Why do cells communicate? Regulation - cells need to control cellular processes. Environmental Stimuli - cells need to.
Receptors & Signaling. Assumed Knowledge Structure of membrane proteins Ion concentrations across membranes Second messengers in signal transduction Regulation.
Cellular receptors By Poppy and Jake. Intracellular receptors Where are they? What binds to them? Intracellular (duh) Some are in the cytoplasm and some.
Chapter 11 Cell Communication. Question? u How do cells communicate? u By “cellular” phones. u But seriously, cells do need to communicate for many reasons.
Cell Signaling How to Get a Message from the outside of the Cell to the inside of the cell.
Chapter 7 Cell Communication. Question? u How do cells communicate? u By “cellular” phones. u But seriously, cells do need to communicate for many reasons.
Cell Communication Chapter 11 QUESTION TO PONDER: How do cells of the body communicate?
Signal transduction The process of converting extracellular signals into cellular responses. extracellular signaling molecules (ligands) synthesized and.
CELL COMMUNICATION. YOU MUST KNOW… THE 3 STAGES OF CELL COMMUNICATION: RECEPTION, TRANSDUCTION, AND RESPONSE HOW G-PROTEIN-COUPLED RECEPTORS RECEIVE CELL.
Cell Communication III. G-protein linked receptor.
AP Bio: Chp.11 Cell Communication. G-protein-linked receptors: vary in their binding sites and for recognizing different G-proteins. Most have seven alpha.
Cellular Signaling Section 2-3. Discussion Points: What happened? How did you recognize where to go? How does this model cell communication? What effect.
Cell Signaling A.Types of Cell Signaling B.Intracellular Receptor Signaling: Steroid Hormones C.Cell Surface Receptors: Types D. Cell Surface Receptors:
Signal Transduction Lecture 14. Ligands & Receptors n Ligand l Neurotransmitters & drugs n Receptor proteins l ligand binds to multiple receptors n Binding.
Mechanism of hormone action. Hormones Three types –Proteins Glycoproteins Small pepstides Large proteins –Lipids Cholesterol derivatives Eicosanoids –Amino.
Signal Transduction and Secondary Messengers Mahmoud Farhat.
11.2 Reception: A signaling molecule binds to a receptor protein, causing it to change shape A receptor protein on or in the target cell allows the cell.
Chapter 11 notes Cell Communication. The Cellular Internet Trillions of cells in a multicellular organism must communicate together to enable growth,
Chapter 11 Cell Communication. LE 11-2 Exchange of mating factors Mating Receptor a factor a a factor Yeast cell, mating type a Yeast cell, mating.
Part V Second Messengers. The first messengers being the extracellular signal molecules and the third messengers being the large protein kinases and phosphatases.
MAIN IDEAS CHAPTER 11: 1. Cell communication processes share common features that reflect a shared evolutionary history. 2. Cells communicate with each.
CHAPTER 11 CELL COMMUNICATION Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Section B: Signal Reception and the Initiation.
11.3 Transduction: Cascades of molecular interactions relay signals from receptors to target molecules in the cell Signal transduction usually involves.
Cell Signaling. Pathways with friends helps understand…
Cell Communication Chapter 11 Biology Campbell Reece.
Regulation of Metabolism FCSN 543 Advanced Nutritional Biochemistry Dr. David L. Gee.
Chapter 11: Cell Communication Word Roots: liga- = bound or tied to trans- = across Ligand – a small molecule that specifically binds to a larger one.
Cell Communication Reception, Transduction, Response.
Cell Communication By Balaji Krishnan. Learning Objectives.
Chapter 14. Signal Transduction Signal transduction is the process by which an extracellular signal alters intracellular events. 1. First and second messengers.
Vander’s Human Physiology The Mechanisms of Body Function Tenth Edition by Widmaier Raff Strang © The McGraw-Hill Companies, Inc. Figures and tables from.
Caffeine Signaling via Ligand-Receptor Binding Agonist - ligand binding to a receptor and eliciting a response Antagonist - ligand binding to a receptor.
Chapter Differentiate between the following: Paracrine Endocrine Autocrine.
Cell Communication Chapter 9. Please note that due to differing operating systems, some animations will not appear until the presentation is viewed in.
Signal Pathways in Eukaryotic Cells Overview. Lipid Soluble Hormones.
Biomembrane and Cell signalling BCH 452(V) Cell To Cell Comunication Dr. Samina Hyder Haq Assistant professor Dept of biochemistry Collage of Science King.
CELL RECEPTORS AND SIGNALLING By Phil and Alex. Basics Signalling controls all aspects of cell behaviour: Growth Differentiation Metabolism 3 main types.
BASIC PHARMACOLOGY 2 SAMUEL AGUAZIM(MD). PHARMACODYNAMICS Pharmacodynamics describes the actions of a drug on the body and includes the principles of.
Cell Communication How do cells “talk” to each other?
Membrane Function Signal Transduction. I. Introduction to Receptors & Signal Transduction.
1 © Patrick An Introduction to Medicinal Chemistry 3/e Chapter 6 PROTEINS AS DRUG TARGETS: RECEPTOR STRUCTURE & SIGNAL TRANSDUCTION Part 3: Section 6.7.
Chapter 15: Signal transduction Know the terminology: Enzyme-linked receptor, G-protein linked receptor, nuclear hormone receptor, G-protein, adaptor protein,
BIOCHEMISTRY MEDICAL FACULTY USU. Intercelluler Communication All cells detect and respond to environmental stimuli Intracelluler communication : -
Today’s lecture More about G proteins Second messengers from lipids Calcium is a second messenger Nitric oxide is a second messenger more neat things about.
AP Biology Cell Communication. AP Biology Communication Methods Cell-to-cell contact Local signaling Long distance signaling.
Chapter 11. Signaling Types Two main types Local signaling Also called paracrine signaling Influence cells in the local vicinity Ex. Growth.
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