PRODUCTS For Bayer - Tablet form - Liquid form - Pomade form For Sandoz -Pellet form - Tablet form
Industrial Pollution According to manufacturing steps, air emissions, liquid effluents ( wastewater) and solid wastes may be generated. To reduce the wastes, They reuse and recycle. Remaning wastes is treated according to characteristic.
Acts& Standards Treated wastewater should be discharged; According to The Control of Water Pollution Management ( 04.09.1998) Discharge Standards For Pharmaceutical
Acts& Standards Hazardous wastes are removed accoding to Control of the Hazardous Wastes -APPENDIX 11-A - APPENDIX- 6
Weighing and mixing: raw materials from the warehouse to weighing part. The weighing is made by the Automotic Container Weighing System. mixed at the mixer for desired revolution and time. The aim homogeneous mixing.
Granulation: The aim homogeneous granules Weighing is again The solution is prepared,added raw materials. The demineralized water can be added if it is required. The prepared granule is sifted (sieving). Dried to reach a certain moisture value.
Tabletting: The mix that is dust, is collected to press machine. The pressing is applied. Some portion of the sample is taken and sent In Process Control (IPC) after approval the ICP it is continued to tabletting.
Film Covering: The tablets, are taken to the film covering boiler. A solution is prepared homogeneously and sprayed to the tablets. After that the tablets are dried at a certaion temperature in the same boiler.
Packing: This part is seperated to 2 parts: Primer and Seconder Parts. In the primer part the blisteration process is made. In the seconder part the boxing and packing is made.
Warehousing : The boxes, that will be sent to pharmacies, are packed with polyethylene as groups of 5 or 10. At final they are packaged and warehoused.
Potential Environmental Issues Air emissions Wastewater Solid and hazardous wastes
Air emissions Volatile organic compounds(VOCs) Acid gases Particulates Greenhouse gas emissions (Combustion Source Emissions)
Volatile Organic Compounds significant emissions of VOCs come from In secondary pharmaceutical manufacturing; mixing, compounding, granulation, and formulation operations involving the use of solvents (e.g. granulation) alcoholic solutions (e.g. tablet coating)
How can control the VOCs emissions? Also odor problem. wet scrubbers
Wet Scrubbers At total 5 wet scrubbers Retention time = 4.6 to 6.5 sec Velocity = 1.2 to 1.7 m/sec
Particulate Matter The most common sources of particulate include milling mixing compounding formulation tableting packaging
Air emissions Particulates Solution ; hepa filters