3I. Hyperthyroidism (Thyrotoxicosis) Characterized by hypermetabolism of all body systems & increased serum levels of free thyroid hormones.More common in women.Rare in childrenLess common than hypothyroidism
4Thyroid Storm:Exaggerated form of hypertoxicosis.Medical emergency Prompt treatmentMay be precipitated by : -Infection-Trauma- Surgery-Embolism-Diabetic ketoacidosis-Others…
5Subclinical Hyperthyroidism: Suppressed TSH level w/ NL thyroid hormone levels.Symptoms are NOT always present esp. in elderly.Pathophysiology: See p
6Treatment Goals of Hyperthyroidism: Reverse S/S, normalize thyroid hormone levels, min. deleterious S/Es of T₄ on organ systems, prevent thyroid storm, & improve overall functional capacity.Reverse hyperthyroid complaints.Reverse hyperthyroid physical findings.Normalize free T₄, T₃, & TSH levels.Reduce goiter size.
7Improve cardiac function & prevent systemic embolism.7) Preserve bone density& prevent osteoporosis.8) Improve emotional well being& quality of life.9) Support placenta development & maintenanceof pregnancy.10) Promote normal growth, & physical &mental development.
8Causes of Hyperthyroidism: (table38.3 p.993) Graves disease: -Autoimmune-May occur w/ other autoimmune disorders.-Most common cause-Charact. by hyperthyroid. &one or more of thefollowing: * Goiter* Exophthalmos* Dermopathy
92) Toxic Nodules: -Single & multinodular -Autonomous: independent of TSH control. -May be caused by: *Iodine deficiency *Genetic abnormality *Immune System
103) Subacute Thyroiditis: - Inflammatory thyroiditis, i. e 3) Subacute Thyroiditis: - Inflammatory thyroiditis, i.e.Postpartum(PPT), viral (i.e. de Quervain). - Hyperthyroid. from leakage of thyroid hormones into circulation due to inflamed gland & NOT increased synthesis. -Hypothyroidism may follow.
114) Drug Induced: -Iodides (Jod-Basedow), Amiodarone, Lithium, Cytokines 5) Neonatal thyrotoxicosis (Graves): -Transplacental passage of TRab causing the infant to be extremely ill w/in delivery hrs. -Self-limiting.
126) Hashitoxicosis: -Hyperthyroid phase of Hashimoto thyroiditis 7) T₃ toxicosis: -Preferential secretion of T₃, often precedes T₄ toxicosis. 8) Tumors: -Secretion of thyroid stimulating substances. 9) Factitious: -Self-administration of levothyroxine
15Clinical Presentation & Diagnosis: - Characteristics of Graves Dz. p.997 Table 38.6-SxS of Hyperthyroidism & Hypothyroidismp.995 Table 38.4- Thyroid Function Tests (TFTs) p
16Diagnosis of Hyperthyroidism : Confirmed w/ abnormally high levels of FT₄ or TT₃ & undetectable TSH.2) +Antibodies, opthalmopathy, or dermopathyconfirms the diagnosis of Graves.3) RAIU in Graves but is NOT cost-effective4) TT₃ & + TRab are essential for atypical presentation, i.e. in elderly.
175) Subacute Thyroiditis (PPT,…), Diagnosis is confirmed by: 5) Subacute Thyroiditis (PPT,…), Diagnosis is confirmed by: *Low or undetectable RAIU. * TH levels. *Suppressed or undetectable TSH level. * ESR * No Thyroid Ab. * Leukocytosis, gland tenderness, & S/S of hyper or hypothyroidism.
25Therapeutic Plan: (table 38.7, p.998-999) Major Modalities for Management of Hyperthyroidism, include:1) Thioamides2) RAI3) Surgery** Treatment must be individualized, each hasadvantages & limitations**Effective Treatment Selection p.1000, Fig.38.3
26Treatment Adjuncts:IodidesIodinated Contrast MediaK PerchlorateAdrenergic AntagonistsCorticosteroidsCholestyramineRarely Li
27In U. S. , RAI is most commonly used except in younger pts In U.S., RAI is most commonly used except in younger pts. for whom Thioamides are used.In Europe & Japan, Thioamides are the TOC.Surgery is the last choice unless there is:*Obstructive symptomsor* Malignancy
28Treatment is individualized a/c to: 1. Etiology2. Pt. age3. Goiter size4. Thyroid & Medical complications5. Social & Economic issues
29Graves: All 3 methods are effective but pt. or Dr. may. prefer meds Graves: All 3 methods are effective but pt. or Dr. may prefer meds. over RAI or surgery.TMG: RAI or surgery > effective than meds.,but factors as medical condition or pt or Dr. may prefer RAI use over surgery.3.Transient Treatment : may be used when thedisease is self-limited, i.e.:* Subacute Thyroiditis (PPT,…)*Neonatal Graves*Drug-Induced Hyperthroidism
30In Uncomplicated Graves esp In Uncomplicated Graves esp. in children, Thioamides are preferred until remission.Thioamides: - Do NOT destroy the gland- Control the disease- Chronic thyroid replacement may not be necessary (not like w/ RAI or Surg.), however, hypothyroid. may still developeventually.
31If RAI or Surgery is selected, most older pts If RAI or Surgery is selected, most older pts. & all severely ill thyrotoxic pts. should be pretreated w/ Thioamides.Pretreatment:Depletes gland of stored hormones.Hypermetabolic rate.Prevents leakage of hormone from gland after RAI or during surgery preventing thyroid storm.
32Optimal Tx of hyperthyroidism in Graves opthalmopathy is unresolved. Some prefer RAI or surgery (<desirable) to remove the antigen source (gland) & > effective than thioamides to prevent progressive opthalmopathy.Prophylactic systemic corticosteroid (e.g., Prednisone 30-40mg daily starting within a few days of RAI & cont. for~2-3 wks. to prevent further progression of opthalmopathy in pts. w/ re-existing cases.Hypothyroidism can aggravate preexisting eye complaints.Hyperthyroidism control & hypothyroidism prevention are essential to prevent progression of opthalmopathy.
33Single or Toxic multinodular Dz.: Best managed with definitive Tx, i.e. RAI or surgery, because spontaneous remission is unlikely.Hyperthyroid Children:The usual Tx choices are Thioamides & subtotal thyroidectomy, although all 3 methods have been used.
34In Pregnancy:Hyperthyroidism is difficult to manage.Spontaneous remission may occur because of the decrease in TRab.Antithyroid meds. are often NOT necessary.If untreated, complications may occur.RAI & Iodides are Contraindicated in pregnancy.Surgery in 2nd trimester is an option.
35Neonatal Graves:Infants extremely ill w/in delivery hrs.Supportive measures, i.e. *sedation*O₂*Fluids/ElectrolytesShort-term (temporary) thioamides, iodides, or beta blockers since it is self-limiting.Symptoms disappear in 1-2 months, therefore, withdraw antithyroids at this time.
36Subacute Thyroiditis: Self-limiting (common spontaneous recovery).Symptomatic treatment: *Heat*Rest*NSAIDs*Beta-blockers* Thioamides are NOT effective since it is due to thyroid hormone leakage & NOT increase in TH synthesis.
37Cont. Subacute Thyroiditis: Corticosteroids are indicated for severe inflammation if NSAIDs are ineffective.In Hypothyroid phase: Transient thyroid replacement is used to suppress further TSH stimulation to damaged gland & treat hypothyroid symptoms.
42Treatment: Fig.38.3 p.1000Pharmacotherapy:Thioamides:*Long-term 1⁰ therapy for Graves esp. in children& adolescents.*Transiently used to reduce TH levels beforedefinitive therapy w/ RAI or surgery.*TOC for small goiters & mild dz. For whom a highremission rate is likely.
43Advantages:Potential for remission without gland damage.Limitations:1.Non-adherence2.Strict parental & physician supervision in kids.3.Low success rates.4. Risk of ADRs.
44Thioamides:Methimazole2. Propylthiouracil (PTU)They prevent TH synthesis.PTU (Not Methimazole) inhibits peripheral deiodination of T₄ to T₃.They suppress TSH receptor Ab level by unknown immunosuppressive MOA.
45Thioamides Selection: Pharmacologic Differences:** Methimazole is preferred over PTU, because:1. Single daily dose ( PTU Q6-8H)2. More potent than PTU3. Less toxic than low doses.4. Less costly.** Both are equally equipotent doses.
46PTU is preferred over methimazole in pts. w/ **Thyroid StormOr **Severe HyperthyroidismBecause:PTU blocks the conversion of T₄ to T₃ peripherally.PTU may have faster OA.*PTU is preferred in pregnancy because methimazole may be associated w/congenital skin defect ( NOT sufficiently supported & has been used inpregnancy without deleterious effects).*Both can be used safely in pregnancy*PTU is preferred in lactation because insignificant amounts are secreted inthe breast milk.*Generally, Methimazole is the thioamide of choice EXCEPT in thesituations mentioned above where PTU is preferred , or if the patientcannot tolerate methimazole.
47No IV preparations of thioamides. It usually takes 6-8wks before SxS subside & TH normalize.Initial dose:Methimazole mg/d orallyor PTU mg/d in 3-4 divided doses.**Tapering down dose only after SxS subside:**Initial dose is reduced gradually by 1/3 each month until daily M.D. of 5-15mg methimazole or mg PTU is reached.
48Baseline FT₄ & WBC count w/ differ Baseline FT₄ & WBC count w/ differ. should be done before thioamides are started because agranulocytosis can be induced by thioamides & also hyperthyroidism is associated w/ relative reduction of neutrophils.FT₄ or FT₄I & TSH should be monitored 4-8 wks after starting Tx & after any dose change.Once stable thioamide M.D. is reached, TFTs should be monitored Q 2-4 or Q3-6 months.
49Recommended duration of Tx for Graves is emperic: Generally 12-18 months. 12 months is the minimum Tx duration recommended to maximize remission potential.Longer durations can be used if NO ADRs.Some pts. remain in remission & others relapse ????
50Toxic Reactions:Pruritic Maculopapular Skin Rash:Most common & treated w/ antihistamines.Hepatatis:*If LFTs normalize w/in 3 months of dosereduction, NO need to discontinue PTU.*If there is clinical evidence of hepatitis,D/C PTU immediately.* Routine monitoring of LFTs is required for:1. Pts. w/ liver dz. history.2. Hepatitis risk factors, i.e. alcoholism
513) Hypoprothrobinemia (w/ PTU):. Rare 3) Hypoprothrobinemia (w/ PTU): * Rare * Recovery may occur after D/C of PTU, if not start steroids. 4) Agranulocytosis (PMNs<500): *Most serious but rare. * Likely to occur during the 1st 6 wks of Tx. * Complete recovery is seen a few days to 3 wks after D/C of thioamide. * Granulocyte colony-stimulating factor & corticosteroids may shorten the recovery period.
522) K Perchlorate: MOA: Interferes w/ Iodine binding causing discharge of non-organified iodide from the gland. *Especially useful for the short-term management of drug-induced hyperthyroidism because it is competitive inhibitor of iodide, but its antithyroid effect can be overcome by iodine administration. *Short-term adm. (2-6wks) is well tolerated. *Limited use of chronic Tx is due to: 1) Irreversible aplastic anemia 2) Nephrotic syndrome
533) Iodides:. Clinical use superseded by thioamides & beta blockers 3) Iodides: *Clinical use superseded by thioamides & beta blockers. *MOA: 1)Inhibit iodide organification (Wolf-Chaikoff). ** 2)Inhibit TH release (Rapid Sx relief in 2-7d) 3)Decrease gland vascularity. *Rapid effect is beneficial for: 1. Thyroid storm 2. Pts. awaiting thioamide onset
54Iodides are NOT to be given before RAI because iodides block effective RAI retention by the gland for several wks. after use.Iodides are given 10-14days before surgery to:1. Reduce vascularity2. Increase firmness of hyperplastic glandto facilitate surgical removal.Preoperatively:Iodides+ Thioamides Comb. ( Preferred )Iodides + Beta Blockers Comb.All 3 of them could be used.
55Major S/Es of Iodides:Hypersensitivity reactionsHyperthyroidism ( from failure of Wolff-Chaikoff block)Hypothyroidism ( unable to escape from Wolf-Chaikoff)Chronic adm. in pregnancyfetal goiter & asphyxation
56Advantages of Iodides: SimplicityLow costLow toxicityNo gland destructionLimitations:EscapeTx relapseAllergyInterference w/ subsequent RAI therapy
574) Adrenergic Blockers: 4) Adrenergic Blockers: **Depletes or blocks the effects of TH on tissue catecholamines Rapid symptomatic relief before thioamides, RAI, or surgery. *Do NOT affect underlying dz. *Are NOT used as primary therapy *Propranolol Standard & most widely used (20-40mg TID or QID)
58Severe toxemia may need up to 480mg/day Symptoms relieved by beta-blockers include:*palpitations*tachcardia*anxiety*sweating*tremor*diarrhea*Neuromuscular manifestationsSymptoms NOT affected by beta-blockers include:*circulating TH*Wt. loss*goiter*O₂ consumption*exophthalmos
59Beta-blockers are used as adjunct Tx w/ thioamides or RAI for: *Neonatal thyrotoxicosis*Hyperthyroidism in pregnancy*Thyroid storm*Pre-operativelyOnly used for short term in pregnancy because chronic use in pregnancy esp. 3rd trimester & lactation should be avoided due to fetal complications.
60Calcium Channel Blockers esp. Diltiazem p.o. 120mg TID or 60mg QIDmay be used as alternative to beta blockers when contraindicated, i.e. asthma or DM1
615) RAI: Radioactive Iodine) *Indicated for:Post-adolescent hyperthyroid patientsGraves opthalmopathyHx of thyroid surgeryPoor surgical candidatesWho fail or experience thioamide toxicityTOC for older patients w/ cardiac dzor those w/ TMGs (Toxic Multinodular Goiter)**I₁₃₁ isotope is the most commonly used**Absolute contraindication in pregnancy: destroys the fetalgland .
62RAI dosage is calculated using a certain formula. RAI pts. should be pretreated w/:*thioamides to deplete the gland of the stored THOr*beta blockers or Ca channel blockersbefore & after RAI to prevent exacerbations ofthyrotoxicosis w/in 10-14days after RAI due to leakageof TH after RAI.*Methimazole: *preferred as pretreatment over PTU*showed > success as preTx.*because PTU is associated w/poorer RAI retention & higher RAI failure rates
63Resolution of hyperthyroidism is slow: Sx improvement :by 3-6wks after RAIMax. effect : 3-4 months after an ablative doseOther therapies may be needed after RAI due to delayed onset for symptomatic control.Major concerns: *Carcinogenesis* Leukemia* Genetic damagewhich are unfounded.
64Advantages of RAI:1) Effective2) Quick3) Painless4) NontoxicMajor Complications:Hypothyroidism : Most common in the 1st year& increases w/ time.
65Iodinated Contrast Media:(e.g. Ipodate) Inhibits peripheral deiodination of T₄ to T₃.Inhibits TH secretion.Relatively non-toxic.Useful adjuncts to thioamides in the management of:Severe thyrotoxicosisThyroid stormAmiodarone-induced thyrotoxicosisAlternative for those allergic to thioamidesin the preoperative preparation** Chronic use is not indicated because its effectiveness inreducing TH is not sustained for more than 1 month in mostcases.
66Non-pharmacological Therapy: Surgery (Thyroidectomy):Treatment of Choice for:1. Contraindications of RAI or Thioamides.2. Large goiters causing:*cosmetic disfigurement* resp. distress* swallowing difficulties3. Suspected Malignancies.4. Selected children & pregnants.
67Euthyroidism produced by surgery is faster & is assoc Euthyroidism produced by surgery is faster & is assoc. w/ lower relapse rates than w/ RAI or thioamides.Poor Surgical Candidates:Severe cardiac, resp., or debilitating dz.3rd trimester pregnant (spontaneous labor)**Risk of recurrent thyrotoxicosis is directlyproportional to amount of remnant left of the gland.**Subtotal Thyroidectomy is preferred
68Total thyroidectomy:1. Increases the risk of hypothyroidism2. Prevents recurrence of hyperthroidismSurgery pts. should be adequately prepared w/standard combination of:1. Thioamide2. Iodidesor 3. Beta-blockers
69Major Surg. Complication: *Hypothyroidism in the 1st 6mos-3yrsafter surg.or as late as 10yrs. after surgery.Advantages of Surgery:Rapid recoveryDefinitive surgical intervention3. Lack of need for the rigid dosing schedule of the thioamidesDisadvantages of Surgery:1. Expense2. Need of hospitalization3. Risk of anesthesia4. Postoperative complications5.Fear of surgery
70Special Treatment Issues: 1.Subclinical Hyperthyroidism:Tx is controversialTx is considered for high risk pts.:*>60y.o.*Cardiac dz.*Atrial Fibrillation*Osteoporosis* Without risk factors: Observe & Do routineTSH monitoring
712. Exophthalmous & Ophthalmologic Complications: *Ocular Tx: symptomatic till euthyroidism occurs*Elevation of bed head for diuresis.*Protective glasses+Methylcellulose (lubricant)Hydrocortisone drops*Avoid smoke & dust*Tape eyes during sleep to prevent corneal scarring & drying.*Systemic corticosteroids for progressive inflammatory exophthalmous & reducedvisual acuity: Prednisone mg/d in divided doses X 1-3 wksthen taper when sxs resolve over 2 wksthen Discontinue.External orbital radiation therapy for contraindications to corticosteroids.After euthyroidism & stable eye Sx Lid or orbital surgery for cosmetic or visual correction
723. Atrial Fibrillation & CHF: 3. Atrial Fibrillation & CHF: *Hyperthyroidism or subclinical hyperthyroidism can cause or worsen A. Fibrillation & CHF which are difficult to control until euthyroid. *Hyperthyroid pts. Resistant to Digoxin *Hypothyroid pts. Very sensitive to Digoxin * Warfarin is recommended in pts. w/ hyperthyroidism-related A.Fib, valvular dz.,& CHF due to high risk of systemic emboli
734. Thyroid Storm:*Treatment:Support vital signs w/:*Sedation*O₂*Fluids/Electrolytes*Antipyretics*Treat infection*Corticosteroids (Hydrocortisone mg I.V. Q6H)2. Thioamides & Iodides in large doses:*PTU mg Q6Hor*Methimazole 30-40mg Q6H*Iodides added 1hr after thioamidesLithium used if iodides are contraindicatedCholestyramines may also be recommended
74Thyroid Storm cont.:Propranolol 20-80mg p.o. Q6H or 0.5-2mg IV or comparable beta-blocker or Diltiazem mg p.o. TID or QID to control HR.Eliminating & correcting precipitating factors.6. Removing circulating hormones by:a. Plasmapheresisb. Exchange transfusionc. Dialysiswhen routine measures fail.TSH is the most sensitive for diagnosis.
76Hypothyroidism:Caused by TH deficiency.Characterized by slowing down of all body systems.Myxedema:Exaggeration of SxS of severe prolonged hypothyroidism preceding comaMyxedema Coma:End-stage of long-standing uncorrected hypothyroidism.Cretinism or Congenital Hypothyroidism;Hypothyroidism developing in the utero or in neonates& can lead to mental & growth impairment.
77Subclinical Hypothyroidism: Increased TSH & Normal TH usually withoutsymptoms of hypothyroidism.* Primary Hypothyroidism:*Failure of thyroid gland to secrete sufficient TH*Most common typeSecondary Hypothyroidism:RareDue to pituitary or hypothalamic injury.
78Treatment Goals: p.1007More common in femalesRisk Factors:1.Family hx of thyroid or autoimmune disorder2.Older age, esp. women3.Medically treated thyroid dz.Types of Hypothyroidism by cause:GoitrousNongoitrous
79Goitrous forms include: *Hashimotos thyroiditis: *Most common in U.S.*Autoimmune*Drug-induced thyroiditis: *Iodides*Lithium*Cytokines*Thiocyanate*Dyshormogenesis: *Familial thyroid disorders from abnormalities in synthesis, delivery,or peripheral action of TH.*Endemic thyroiditis: *Caused by Iodine deficiency during growth years.*Subacute Thyroiditis*Multinodular Goiters (MNG)
802. Nongoitrous forms include: *Cretinism *Idiopathic atrophy (uncommon) *Iatrogenic causes: *2nd most common *by RAI or surgery *Pituitary causes (uncommon)
81SxS: * Table 38.4* Atypical in elderlySxS from naturally occurring hypothyroidism(Hashimoto): insidious & unnoticed x mos-yrsbefore terminal myxedema state.Iatrogenic Hypoth. (by RAI or Surgery):occur rapidly.
82Hypothyroid. pts. : sensitive to meds. i.e.: *Digoxin*Anesthetics*Narcotics*Sedatives-hypnoticsMedical Tx of concurrent diseases (DM, Hyperlipidemia, Cardiac conditions):Maybe influenced
83Diagnosis: May go unnoticed Recommended to measure TSH 35y.o. & every 5 yrs thereafter esp. in women.Adults:* Low FT₄I or FT₄ (T₃ may be normal)* Increased TSHSecondary Hypothyroid:*Low FT₄*Low TSH*Other features of pituitary or hypothalamic dz.Hashimoto Thyroiditis:*Antibodies present
84Therapeutic Plan: Fig. 38.4 p.1011 TH administration provides adequate replacement therapy for Hypothyroidism & prevents progression to myxedema coma.Average Dose= mcg L-thyroxine QD(parallels normal TH production)* mcg QD in females* mcg QD in malesDosing requirements depend on:age, weight, severity, cause, cardiac dz.,hormone absorption.
85Treatment:Pharmacotherapy:L-thyroxine: Preparation of choice.Other commercial preparations (table 38.9)Young-healthy pt. w/ short duration dz.:Administer L-thyroxine mcg QD( mcg/kg/d)Dose can be adjusted using SxS & lab values@ steady-state (after 6-8 wks of Tx)
86Older pts.= mcg QDOld w. Cardiovascular Dz.= 25 mcg QDLower doses are sufficient for hypothyroidism caused by RAI or surgery than with spontaneous hypothyroidism.Pregnancy: Increase the pre-pregnancy doseof L-thyroxine by 20-30% in 1st or nd trimester.
87Malabsorption by SBS or coadministration w/ several meds. (tab. 38 *Malabsorption by SBS or coadministration w/ several meds.(tab.38.10)Reduces thyroxine absorption *Improvement in typical SxS should be seen after 3-4 wks of Tx. *Wt., skin, hair, voice changes: May NOT reverse for months despite normal TFTs. *TSH & FT₄ : Should be SS (after 2-3 mos. of daily dosing) *Changes in TSH lag behind changes in TH. Therefore, TSH & T₄ should be checked NOT earlier than 4 wks after starting Tx. *Once dose is established: Evaluate yearly intervals
88Avoid over-replacement to avoid hyperthyroidism which can increase the risk of: * osteoporosis * Bone loss* Cardiac arrhythmias1. L-thyroxine (T₄) whose t⅟₂=7days: The most popular of the 8 commercial preparations because of:1. Potency2. Cost-effectiveness3. Lack of foreign protein antigenicity4. Ease of dosing
89T₃ (t ⅟₂=1.5d):* May be used for short-term replacement.*NOT recommended for routine Tx due to its:1. Cardiotoxic effect2. Multiple daily dosing3. Greater difficulty in monitoring therapeutic& toxic responses.4. High cost
903) T₃+T₄ Combination:Needs to be further investigated4) Dessicated Thyroid from Animals:Considered obsolete although inexpensivedue to allergic reactions & abnormal TFTs.
91Special Treatment Issues: Congenital Hypothyroidism:*The earlier the Tx begins, the better theprognosis of mental & growth development.*DOC: L-thyroxine*Infants w/ long standing & severe myxedema:Extremely sensitive to minute doses of TH*Start w/ very small doses (tab.38.11) to preventtoxicity.* TSH should normalize after 3-4months of starting Tx.
922) Subclinical Hypothyroidism: *Treatment: Debatable*Not all cases progress to hypothyroidism:Higher TSH elevation , greater risk*Risk is greatest w/ TSH > 10mIU/L*Decision to treat is based on:Risk vs. benefit of TxLikelihood of overt hypothyroid (hx RAI or surgery)Degree of TSH elevationHx of thyroid dz.
933) Myxedema Coma: Hormone replacement + Supportive measures c. Eliminate or correct precipitating factors
94a. Hormone Replacement: L-thyroxine: Large IV dose ( mcg)then M.D mcg IV QDuntil p.o. is possible.Hydrcortisone: mg IV Q6H:To prevent adrenal crisis in case of undetectedhypopituitarism exists.
95b. Supportive Measures: 1. Assisted ventilation 2 b. Supportive Measures: 1. Assisted ventilation 2. Glucose infusion for hypoglycemia 3. Fluid restriction due to hyponatremia 4. Plasma expanders for shock & circulatory collapse **Heating blankets: NOT recommended because it can aggrevate shock by vasodilation. c. Eliminate or Correct Precipitating Factors ** If properly treated, Recovery can occur w/in 24 hrs.