Presentation on theme: "Infectious complications of hemodialysis catheters"— Presentation transcript:
1 Infectious complications of hemodialysis catheters Müjdat YENİCESU, M. D.October 24, 2014
2 Hemodialysis Catheters Non-tunneled, non-cuffed cathetersTunneled, cuffed cathetersYou are seeing here, both non-tunneled, non-cuffed catheters and tunneled, cuffed catheters are available. At present, tunneled, cuffed, double-lumen catheters are the preferred access for short- and long-term use in dialysis patients.
3 Summary of bloodstream infection data Major and the most serious complication of HD catheters is infection.If you look at BSI data according to Access type, nativ AVF have the lowest rates of infection. Synthetic AV grafts have intermediate risk and catheters have the highest risk.In this study, published 2002; researchers from the US, report here the result of 36 months vascular Access infection surveillance. Infection rate is the highest ptnts with hdx catheters for 1000 DSs, the lowest ptnts with AV fistulae for 1000 DSs.AJKD, 2002; 39 (3):
4 Frequencies and complications of catheter-related bacteremia in hemodialysis-patients M. Allon. Dialysis catheter-related bacteremia treatment and propylaxis. AJKD, 2004 (5):
5 Risk factors for catheter-related bacteremia Duration of catheterizationConditions for insertionCatheter site and catheter site careRepeated catheterizationIncreased catheter maniplationTunneled vs nontunnelled cathetersImmunosuppressive therapyHypoalbuminemiaAJKD 2004, 44(5): 779AJKD 2005, 46(3): 501KI, 2000; 57(5): 2151
6 The most important risk factor for tunneled catheter-related bacteremia is prolonged duratiom of usageAJKD, 2005; 46 (3): 501. Lee T. Et all, «Tunneled catheters in hemodialysis patients: Reasons and Subsequent Outcomes»
8 Clinical manifestations of hemodialysis catheter infections Fever and/or chillsPurulence at the catheter insertion siteHemodynamic instabilityCatheter dysfunctionHypothermiaAcidosisHypotensionManifestations of metastatic infectionsAlthough nonspecific, fever and/or chills are the most sensitive clinical manifestations of catheter-induced bacteremia. In three prospective clinical studies, the presence of fever or chills in catheter-dependent hemodialysis patients was associated with positive blood cultures in approximately 60 to 80 percent of patients.UpToDate, 2014
9 Evaluation, diagnosis and differential diagnosis CRB suspect threshold should be low.Two blood cultures should be drawn;Peripheral vein and catheterSeparate peripheral veinsDifferential diagnosis includes pneumonia, foot infection and other infectionsUpToDate, 2014
10 The definitive diagnosis of CRB requires one of the following Concurrent positive blood cultures of the same organism from the catheter and a peripheral vein.Culture of the same organism from both the catheter tip and at least one percutaneous blood culture.Cultures of the same organism from two peripherally drawn blood cultures and an absence of alternate focus of infection.UpToDate, 2014
11 Management of diaysis-catheter induced bacteremia TREATMENTManagement of diaysis-catheter induced bacteremiaAntibiotic therapyEmpiric systemic antimicrobial therapyTailored systemic antimicrobial therapyRemoval or exchange of catheterUpToDate, 2014
12 Empiric systemic antimicrobial therapy for hemodialysis catheter infection AJKD, 2009: 54(1): 13. Treatment guidelines for dialysis catheter-related bacteremia
13 Methicillin-resistant Staphylococcus With the isolation of a methicillin-resistant Staphylococcus,Continue to administer vancomycin if the organism has a low-minimal inhibitory concentration.Patients with vancomycin allergy can be treated with daptomycin.UpToDate, 2014
14 Methicillin-sensitive Staphylococcus With the isolation of a methicillin-sensitive Staphylococcus,Vancomycin should be substituted with cephazolin.20 mg/kg cephazolin, IV, after each hemodialysis session.Vancomycin is the preferred treatment for patients who are penisillin allergic.1. Cephazolin as empiric therapy in hemodialysis-related infections. AJKD 1998, 32(3):410.2. Use of vancomyin or cephazolin for treatment of hemodialysis-dependent patients with methicillin-susceptible staphyloccocus aureus bacteremia. Clin Infect Dis 2007, 44(2): 190.
15 Vancomycin-resistant Enterococcus Can be treated with daptomycin,6 mg/kg, following a dialysis session in inpatients,7 mg/kg (low- flux dialyzers), during the last 30 minutesof each dialysis session,9 mg/kg (high-flux dialyzers) , during the last 30 minutesof each dialysis sessionIntradialytic administration of daptomycin in end stage renal disease patients on hemodialysis CJASN 2009, 4(7):1190
16 Gram-negative organisms Up to 95 percent of Gram-negative bacteria isolated in dialysis catheter-related bacteremia are presently sensitive to both aminoglycosides and third-generation cephalosporins.prefer ceftazidime for longer-term treatment, rather than gentamycin, given the risk of aminoglycoside ototoxicity.In regions or institutions in which resistance to ceftazidime is more common, aminoglycosides or carbepenems may be alternate choices.UpToDate, 2014
17 Candidemia catheter removal treatment with an appropriate antimicrobial agentManagement of hemodialysis catheter-related bacteremia with an adjunctive antibiotic lock solution. KI 2002;61(3):1136
18 Evaluation for catheter removal, Monitoring issuesRepeat blood cultures 48 to 96 hours after the institution of treatmentEvaluation for catheter removal,Evaluation for metastatic infection and endocarditis (echocardiography)UpToDate, 2014
19 Duration of antimicrobial therapy for CRB Uncertain. It depends on clinical, microbiologic features and whether the catheter is removedTreat uncomplicated CRB for two or three weeks.Treat uncomplicated CRB due to S. Aureus for four weeks.If there is evidence of metastatic infection, use of antibiotics at least six weeks.When blood cultures remain positive after three or more days of appropriate therapy, use antibiotics at least six weeks.Among patients with osteomyelitis, experts advise treatment for six to eight weeks.UpToDate, 2014
20 Catheter management in case of CRB Immediate catheter removal, followed by placement of a temporary non-tunneled catheter for short-term dialysis access. After bacteremia has resolved, a new tunneled dialysis catheter can be inserted.Replacement of the infected catheter via exchange over a guidewire.Use an antibiotic lock in the infected catheter.Leave the infected catheter in place (no replacing, no an antibiotic lock)UpToDate, 2014
21 Conditions for immediate removal of infected hemodialysis catheters Severe sepsis,Hemodynamic instability,Evidence of metastatic infection,Signs of accompanying exit-site or tunnel infection,If fever and /or bacteremia persist 48 to 72 hours after initiation of antibiotics to which the organism is susceptible,When infection is due to difficult-to-culture pathogens, such as S. Aureus, Pseudomonas, Candida, other fungi, or multiply-resistant bacterial pathogens.UpToDate, 2014
22 Guidewire catheter exchange «If there is no conditions of immediate catheter removal, delayed exchange of the infected cuffed catheter over a guidewire with a new catheter two or three days after institution of effective antimicrobial therapy is a reasonable option.»KI 2000;57(5):2151. Bacteremia associated with tunneled dialysis catheters: comparison of two treatment strategies.AJKD 1995;25(4):593. Catheter-related sepsis complicating long-term, tunnelled central venous dialysis catheters: management by guidewire exchange.KI 1998;53(6):1792. Treatment of infected tunneled venous access hemodialysis catheters with guidewire exchange.Conditions for guidewire replacement of the catheterAfebrile after 48 hours of antibiotic therapyClinically stable patientNo evidence of tunnel tract involvementCJASN 2009, 4: 1102–1105. Catheter exchange over a guidewire in conjunction with antifungal therapy is an effective and safe treatment regimen also in catheter-related candidemia cases.
23 Effect of bacterial pathogen on the success of an antibiotic-lock protocol in hemodialysis patients with catheter-related bacteremiaThe success rate of an antibiotic lock (in conjunction with systemic antibiotics) in curing CRB is highly dependent on the infecting organism. For example, the success rate was highest 87 to 100 percent in patients with gram negative infections, 75 to 84 percent for S. Epidermidis infections, and 61 percent for Enteroccocus infections, but only 40 to 55 percent with S. Aureus infections.M. Allon. Dialysis catheter-related bacteremia treatment and propylaxis. AJKD, 2004 (5):
24 Leaving the catheter in place without intervention Only systemic antibiotics,Without replacing the infected catheter,Without instilling an antibiotic lock,Clinical cure rate, %Eradication of bacteria imbedded in biofilms ?UpToDate, 2014
25 Prevention of catheter related infection General measures;Every dialysis unit must develop written protocol for maniplation of hemodialysis catheters and exit-site dressing technique,Hand hygiene before and after patient contact,Wear nonsterile gloves and masks during catheter procedures,
26 Prevention of catheter related infection Other methods;Elimination of S. Aureus nasal carriage,Topical application of different substances,Utilize antibiotic-lock technique,Usage of different catheters (Are there catheters with a lower infection rate?)impregnated with antimicrobial agents,with subcutaneos port,Usage of Tego needlefree hemodialysis connector
30 Catheter lock solutions Vancomycin/ceftazidime/heparinVancomycin/heparinCeftazidime/heparinCefazolin/heparinGentamycine/heparinTaurolidine30 % citrate70 % ethanolYou are seeing here some kind of lock solutions.
31 Prophylaxis Against Dialysis Catheter–Related Bacteremia: A Glimmer of Hope AJKD, 2008; 51(2):the catheter-related bacteremia frequency was 50% to 100% lower in the group with antimicrobial lock, as compared with the heparin controls.
33 Y. Zhao, Z. Li, L. Zhang and et all. Citrate Versus Heparin Lock for Hemodialysis Catheters: A Systematic Review and Meta-analysis of Randomized Controlled TrialsY. Zhao, Z. Li, L. Zhang and et all.AJKD,2014; 63(3): (13 trials, 1770 patients)
34 Potential barriers against antimicrobial lock solution usage and exit-site antimicrobial application in catheter careAntibiotic resistant microorganisms and infection,Systemic toxicity (ototoxicity/gentamicin; Hypocalcemia/citrate),Economic.
37 Systematic review of antimicrobials for the prevention of haemodialysis catheter-related infections K. S. Rabindranath, T. Bansal, J. Adams, et all.NDT, 2009; 24(12): 3763We do not have sufficient evidence to draw conclusions regarding the effectiveness of antimicrobial coating or impregnation of HD catheters or peri-operative systemic administration of antibiotics in the form of intravenous vancomycin for the reduction of HD-CRI.