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Hamed Alavi Department of Biomedical Engineering University of California USA
Recent P ublications Kheradvar A, Groves EM, Simmons C, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Grande-Allen KJ, Georgen CJ, Mofrad MK, Baaijens F, Canic S, Little SH. Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for mitral valve repair and replacement, Annals of Biomedical Engineering, 2014, Accepted. Safshekan F, Tafazzoli-Shadpour M, Shokrgozar MA, Haghighipour N, Alavi SH. Effects of Short-Term Cyclic Hydrostatic Pressure on Initiating and Enhancing the Expression of Chondrogenic Genes in Human Adipose- Derived Mesenchymal Stem Cells, Journal of Mechanics in Medicine and Biology, 2014, 14(4), 1450054. Alavi SH, Groves EM, Kheradvar A. The Effects of Transcatheter Valve Crimping on Pericardial Leaflets, Annals of Thoracic Surgery, 2014, 97 (4), pp. 1260-1266. Alavi SH, Ruiz V, Krasieva T, Botvinick E, Kheradvar A. Characterizing the Collagen Fiber Orientation in Pericardial Leaflets under Mechanical Loading Conditions, Annals of Biomedical Engineering, 2013,41 (3), pp. 547-561.
HONORS AND AWARDS C. Walton Lillehei Award finalist by the Society of Heart Valve Disease for my project: “A novel hybrid self-regenerative heart valve”, June 2013 Cover Image of June 2013 issue of Tissue Engineering Journal Part B: Reviews, June 2013 2nd place in the 2013 Business Plan Competition at The Paul Merage School of Business at UC Irvine. The awarded business plan is based on my PhD thesis and on the development and commercializing the first patient- specific self-regenerative heart valve, May 2013 Edwards Lifesciences Corporation Fellowship for my research on heart valve tissue engineering, April 2013 Cover Image of April 2012 issue of Tissue Engineering Journal Part C: Methods, April 2012 Center for Complex Biological Systems (CCBS) Opportunity Award for computational reconstruction of the heart in a mouse model of the Cornelia de Lange Syndrome, June 2011
Conference Papers Alavi SH, Sinha A, Kheradvar A. Matrix Remodeling in Native Atrioventricular Valves’ Leaflets in Response to Mechanical Loading. AHA Scientific Sessions 2014, November 15-19, Chicago, IL, USA. (Oral Presentation) Alavi SH, Kheradvar A. Non-degradable scaffolding approach for creation of self-regenerative heart valves, 5th International Conference on Mechanics of Biomaterials and Tissues 2013, December 8 – 12, Sitges, Spain. (Oral Presentation) Alavi SH, Groves EM, Kheradvar A. Examining The Effects of Crimping on Pericardial Leaflets During Transcatheter Aortic Valve Replacement By Quantitative Microscopy, 5th International Conference on Mechanics of Biomaterials and Tissues 2013, December 8 – 12, Sitges, Spain. (Oral Presentation) Alavi SH, Kheradvar A. Development of Self-Regenerative Heart Valves based on Non-Degradable Scaffolding Approach. AHA Scientific Sessions 2013, November 16-20, Dallas, TX, USA. (Poster Presentation) Alavi SH, Groves EM, Kheradvar A. Damage Analysis of Crimping Pericardial Leaflets in TAVI. AHA Scientific Sessions 2013, November 16-20, Dallas, TX, USA. (Poster Presentation)
PATENTS Alavi SH, Kheradvar A. Mesh enclosed tissue constructs, US20140180399, US20120244617, and WO2013025239. 2. Alavi SH, Kheradvar A. Mesh enclosed tissue constructs, US20120245706, WO2013025239, and EP2688562A2. 3. Alavi SH, Kheradvar A. Apparatus and process for growing a heart valve in three-dimensions, US20140154662 and WO/2014/089023A1. 4. Kheradvar A, Alavi SH. Tubular braided scaffold for fabrication of heart valves, Patent Pending. 5. Alavi SH, Kheradvar A. A mesh made heart valve, Patent Pending. 6. Alavi SH, Kheradvar A. A self-regenerative hybrid tissue structure for 3D fabrication of heart valves, blood vessels and other constructs, Patent Pending.
Conference Papers Alavi SH, Kheradvar A. Effect of Stent Crimping on Superficial and Deep Layers of Pericardial Leaflets. Dallas-Leipzig 2012 International Valve Conference, December 5-7, Dallas, Texas, USA. (Oral Presentation) Alavi SH, Ruiz V, Krasieva T, Botvinick E, Kheradvar A. Characterization of Fiber Orientation under Cyclic Load: Correlation to Bioprosthetic Valve Failure. BMES 2012 Annual Scientific Meeting, October 24-27, Atlanta, GA, USA. (Oral Presentation) Alavi SH, Kheradvar A. Self-Regenerative Engineered Heart Valves: From Conception to Performance. BMES 2012 Annual Scientific Meeting, October 24-27, Atlanta, GA, USA. (Poster Presentation) Kheradvar A, Alavi SH. Immediate and Delayed Effects of Stent Crimping on Pericardial Leaflets of Transcatheter Valves. TCT 2012, October 22-26, Miami, FL. (Poster Presentation) Alavi SH, Kheradvar A. TGF-β1 Positively Modulates Cell-metal Interaction in Cardiovascular Applications. AHA BCVS 2012 Conference, July 23-26, New Orleans, LA, USA. (Poster Presentation)
Conference Papers Alavi SH, Ruiz V, Krasieva T, Botvinick E, Kheradvar A. Characterization of Load-Induced fiber orientation in Pericardial Leaflet Tissue. EBR 2012, May 3-4, Marseille, France. (Poster Presentation) Alavi SH, Botvinick E, Kheradvar A. Characterization of Collagen Fiber Orientation by Multiphoton Imaging in Loading-Unloading Phases. BMES 2011 Annual Fall Scientific Meeting, October 12-15, Hartford, CT, USA. (Poster Presentation) Alavi SH, Nazemi L, Liu W, Kheradvar A. Effect of Co-Culture on Immunogenicity of a Tissue Engineered Construct. BMES 2011 Annual Fall Scientific Meeting, October 12-15, Hartford, CT, USA. (Poster Presentation) Alavi SH, Kheradvar A. A Hybrid Self-Regenerative Engineered Tissue for Heart Valve Leaflets. BMES 2011 Annual Fall Scientific Meeting, October 12-15, Hartford, CT, USA. (Poster Presentation) Alavi SH, Kheradvar A. A Hybrid Scaffold for Tissue Engineering of Heart Valve Leaflets. ASME 2011 6th Frontiers in Biomedical Devices, September 26-27, Irvine, CA, USA. (Poster Presentation) Alavi SH, Kheradvar A. A Hybrid Self-Renewal Engineered Tissue for Heart Valve Leaflets. SHVD 2011 6th Biennial Meeting, June 25-28, Barcelona, Spain. (Poster Presentation)
Edwards Lifesciences Center for Advanced Cardiovascular Technology, UC Irvine Animal feasibility study of the first hybrid self-regenerative heart valve, in collaboration with UC Irvine School of Medicine, mentoring a group of postdoctoral scholars, graduate and undergraduate students from UC Irvine during the course of this project (2014 – present) o Research on design and development of heart valve replacements, developing and in vitro testing a novel hybrid self-regenerative heart valve with enhanced biocompatibility and a potential for lifelong durability, mentoring and managing a cross-functional team of postdoctoral scholars, graduate and undergraduate students at multiple institutions (2010 – present) o Research on transcatheter heart valves, investigating the effects of crimping process on pericardial leaflets in time and through the depth of tissue, proposing a new method to eliminate the risks associated with damages caused by crimping process of TAVR (2012 – present) o Research on biomechanics of heart valves, working on the effects of cyclic mechanical loading on collagen fibers orientation of native and prosthetic heart valve leaflets using second harmonic generation microscopy, Introducing a new approach for designing more durable bioprosthetic or tissue engineered
Edwards Lifesciences Center for Advanced Cardiovascular Technology, UC Irvine heart valves, mentoring a group of undergraduate students from UC Irvine and UC San Diego during the course of this project, in collaboration with The Beckman Laser Institute (2011 – present) o Research on biocompatibility of metal implants specifically analyzing the immune response of a novel tissue engineered heart valve, developing a cell masking process to reduce the immunogenicity of an implant, mentoring a group of graduate and undergraduate students from UC Irvine and IQS university of Spain during the course of this project (2011 – 2012) Research on tissue engineering scaffolds, designing and developing a novel hybrid scaffold for tissue engineering of membranes, in a collaboration with University of South Carolina (2010) Developing in-house codes using C++ and MATLAB for 3D reconstruction of complex biological organs such as heart, analyzing the results by Finite Element Analysis (FEA) and Computational Fluid Dynamics (CFD) to obtain stress and strain distributions (2010)
Trauma and Treatment Related Journals Journal of Neurology & Neurophysiology Brain Disorders & Therapy
Trauma and Treatment Related Conferences 4th International conference & Exhibition on Neurology and Therapeutics, July 27-29, 2015 Naples, Italy