9.1 IDENTIFICATION OF DNA AS THE GENETIC MATERIAL
Frederick Griffith Born1879 Died1941 Frederick Griffith “Almighty God is in no hurry, why should I be? “ “Disappointment is my daily bread, but I thrive on it“ He found something in the lab but no in hurry for publication. This is his line. the first widely accepted demonstrations of bacterial transformation
Oswald Theodore Avery (1877-1955) For many years, genetic information was thought to be contained in cell protein. cellprotein He is best known for his discovery that deoxyribonucleic acid (DNA) serves as genetic material
Linus Pauling Linus Pauling (1901-1994) the only person to win two Nobel prizes 1954 Nobel Prize in Chemistry 1962 Nobel Peace Prize He elucidated a-helix structure, and he built ball-and-stick models
Rosalind Elsie Franklin (1920-1958) a British chemist and crystallographer who is best known for her role in the discovery of the structure of DNA It was her x-ray diffraction photos of DNA and her analysis of that data--provided to Francis Crick and James Watson without her knowledge--that gave them clues crucial to building their correct theoretical model of the molecule in 1953
9-54 Figure 9.20 Triplex DNA formation is sequence specific The pairing rules are Triplex DNA has been implicated in several cellular processes Replication, transcription, recombination Cellular proteins that specifically recognize triplex DNA have been recently discovered T binds to an AT pair in biological DNA C binds to a CG pair in biological DNA
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