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Claflin University INBRE Team

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1 Claflin University INBRE Team
Angela W. Peters, Co-P.I. (Chair of Chemistry) Verlie Tisdale, Dean, School of Natural Sciences & Mathematics Rebecca Bullard-Dillard, Asst. Vice Pres. for Research Arezue Boroujerdi, New Target Faculty (Asst. Prof. Chemistry) Kamal Chowdhury, Target Faculty (Interim Chair of Biology) Nick Panasik, Mentor (Asst. Prof. Biology/Chemistry-former Target Faculty) Florence Anoruo, Mentor (Asst. Prof. Biology-former Target Faculty) Randall Harris, Mentor (Asst. Prof. Biology-former Target Faculty)

2 Student Training, Pipeline Development, and Outreach
Highlights for Year 1 Student Training, Pipeline Development, and Outreach Support for academic year training for 10 undergraduate students and summer support for 4 undergraduate students. Students participated in the 2nd annual Open House & Research Day, March 25-26, sponsored by the School of Natural Sciences and Mathematics. 50% of senior thesis projects are from INBRE research. INBRE seniors graduating in May, 2011 have been accepted to: MUSC-Medical School Pharmacy School Post-Baccalaureate Program

3 Faculty Development Support for Target Faculty who have seed projects to further develop them. Kamal Chowdhury, Target Faculty - Development of subunit Malaria Vaccine in Tomato Recent publication: “Identification of most organogenic-responsive variety of tomato using variety x medium interaction”, Romanian Biotechnological Letters, Vol 15 (5): 5640 – 5645, 2010. Nick Panasik, former Target Faculty – Thermodynamic and Structural Mechanisms in Protein Fold Adaptation and Thermostability NSF CAREER Award

4 Faculty Recruitment Arezue Borourjerdi was hired in January 2011.
She is an Assistant Professor in Chemistry and teaches Biochemistry. Through INBRE support, she receives 50% release time and a start-up package.

5 at Mississippi State University
NMR Structure Calculation of the Halophilic Binary hvDHFR1:folate Complex Arezue F. B. Boroujerdi Received Ph.D. in 2008 at Mississippi State University with Dr. John K. Young

6 Boroujerdi, A. F. B., et al. Biomol. NMR Assign. 2007, 1, 139.
Boroujerdi, A. F. B., et al. Bioploymers 2009, 91,

7 Will salt restrict motion as binding does?
Adenosine Binding Loop a2-b3 Loop L21 Loop b6-b7 Loop Boroujerdi, A. F. B., et al. Bioploymers 2009, 91,

8 Metabolic Responses of the Temperature-Dependent Coral Pathogen Vibrio coralliilyticus
Boroujerdi, A.F.B. et al. Environmental Science & Technology, 2009, 43: Arezue F. B. Boroujerdi Daniel W. Bearden National Institute of Standards and Technology (NIST) Hollings Marine Laboratory, Charleston, SC

9 Treatment Bioanalytical tools Overview of the Metabolomics Process
Environmental Metabolomics – study of low MW metabolites in cell, tissue, or biofluid (metabolome) in response to a stress Treatment Toxicological exposure Field collection Tissue or biofluid sample Mass spectrometry NMR spectroscopy (1H , 13C, 31P) Bioanalytical tools Measure the metabolite profile Statistical/Chemometric tools Pattern recognition Quantitative modeling Workhorse: PCA, PLS Treat profile as ‘fingerprint’ for classification purposes Explore profile to gain mechanistic insight into the biological response Modified from Mark Viant, et al (2003)

10 NMR-Based Metabolic Exploration of Serum from Female College Students at USC and CU in Relation to Nutritional and Lifestyle Determinants of High-Risk HPV Persistence Arezue F.B. Boroujerdi, Ph.D. Claflin University Lucia Pirisi, M.D. University of South Carolina School of Medicine The Carolina Women’s Care Study (CWCS)


12 Biomedical Metabolomics at Claflin University
minimally invasive biofluid samples (urine, blood, saliva, etc.) provide a wealth of metabolic information for health assessment and disease diagnosis and treatment NMR-based metabolomics provides an excellent means for collaborative research wide range of topics can be addressed specifically in relation to diagnosis, monitoring of treatment or recurrence, application to translational medicine research or dietary interventions NMR-based metabolomics research is ideal for undergraduate research learn hands-on bench chemistry techniques polar and non-polar metabolite extractions solvent and buffer preparation NMR sample preparation become experienced with collecting and interpreting NMR spectra with the use of multivariate statistical approaches such as principal components analysis (PCA)

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