1. Circulación Cerebral y Demencia Senil

2. Interactions between VaD and AD VaD post-stroke dementia infarcts, white matter lesions (WMLs) vascular risk factors VaD+AD Source: G Roman San Antonio TX Pure AD Pure VaD “ mixed ”

3. Iason Pratensis (Jason de Pratis) published in Basle (1549) the first textbook of neurology De Cerebri Morbis It included a chapter on dementia De memoriae detrimento Pestronk A. The first neurology book. De Cerebri Morbis...(1549) by Jason Pratensis. Arch Neurol 1988 Mar;45(3):341-4.

4. 1 st description of post-apoplectic dementia: “Dullness of mind and forgetfulness and then afterwards …a stupidity and foolishness. In many, stupidity has accompanied the palsie or has gone before apoplexy” De Anima Brutorum 1672 Thomas Willis at age 45 (1667) In Willis' time, the word foolishness (stultitia in Latin, from stultus foolish, meaning "to be of unsound mind") was equivalent to dementia

5. Th. Willis Dementia Post-apoplexy Binswanger, Alzheimer Vascular Dementia Kraepelin Arteriosclerotic Dementia Senile & Presenile AD DSM-I Chronic Brain Syndrome Hachinski Scale Roman Vascular Dementia Erkinjuntti Cortical vs. Subcortical Roman NINDS- AIREN Criteria DSM IV- Executive Dysfunction Katzman: AD is the Main Cause of Atrophy and Dementia DSM-III MID NINDS- ADRDA Criteria for AD 1672 1894 1907 1952 1974 1976 1980 1984 1985 1987 1993 1994 1996 VaD VCD VCI AD VaD DEMENTIADEMENTIA Pathological reports of Alzheimer’s disease CADASIL 1 st genetic form of VaD 2012 A BRIEF HISTORY OF DEMENTIA

6. Cerebral circulation Coronary circulation Source: S Salloway

7. 1854-57 Professor of Chemistry, Lille 1857-67 Director École Normale Supérieure, Paris 1865-70 Silkworm diseases 19 Oct 1868 First stroke, L hemiplegia (Age 46) Pasteur at his laboratory working on the rabies vaccine (portrait by Edelfelt). LOUIS PASTEUR (1822-1895)

8. Pasteur: Left hemiparesis

9. 1854-1857Professor of Chemistry, Lille 1857-1867École Normale Supérieure, Paris 1865-1870Silkworm diseases 19 Oct 1868 First stroke, L hemiplegia (Age 46) 1871-1876Studies on fermentation and beer 1877-1880Anthrax, fowl cholera 1881-1895Rabies vaccine Oct 18872 nd stroke (Age 65) 18943 rd stroke (Age 72) LOUIS PASTEUR (1822-1895)

10. “Common Sense” Reisch Margarita Philosophica (1513)

12. Snowdon D, et al. JAMA March 12, 1997; 277(10): 813-817

15. Concept-changing factors Progress in the neurosciences Neuroimaging Neuropathology Cerebral Blood Flow Neuropsychology Frontal Lobe Genetics Epidemiology Pharmacology

19. special article Vascular dementia: Diagnostic criteria for research studies Report of the NINDS-AIREN International Workshop GC Román, TK Tatemichi, T Erkinjuntti, JL Cummings, J Masdeu, JH García, L Amaducci, J-M Orgogozo, A Brun, A Hofman, DM Moody, MD O’Brien, T Yamaguchi, J Grafman, BP Drayer, DA Bennett, M Fisher, J Ogata, E Kokmen, F Bermejo, PA Wolf, PB Gorelick, KL Bick, AK Pajeau, MA Bell, C DeCarli, A Culebras, AD Korczyn, J Bogousslavsky, A Hartmann, and P Scheinberg NEUROLOGY 1993;43:250-260

20. NINDS-AIREN International Workshop on Vascular Dementia; April 19-21, 1991; NIH Campus, Bethesda, Md NINDS/CSN Workshop Bethesda 2005