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Neural Integration The sensory pathways Chapter 15.

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1 Neural Integration The sensory pathways Chapter 15

2 2 Afferent Division of the Nervous System  Receptors  Sensory neurons  Sensory pathways

3 3 Afferent Division – location in CNS 1.Somatic Sensory info -Sensory cortex of cerebrum -Cerebellum 2.Visceral Sensory info -Reflex centers in brainstem -Reflex centers in diencephalon

4 4 The somatic sensory system  Sensory stimuli that reach the conscious level of perception  Specialized cells that monitor specific conditions in the body or external environment  General Senses:  Temp, pain, touch, pressure, vibration, proprioception  Simple receptors located anywhere on body  Special Senses:  Are located in sense organs such as the eye or ear  Olfaction, vision, gustation, hearing, equilibrium  Complex receptors located in specialized sense organs

5 Table 10-1 (1 of 2) General Properties: Sensory Division

6 From Sensation to Perception

7 Sensory Pathways – from sensation to perception  Stimulus as physical energy  sensory receptor  Receptor acts as a transducer  Intracellular signal  usually change in membrane potential  Stimulus  threshold  action potential to CNS  Integration in CNS  cerebral cortex or acted on subconsciously

8 8 Sensory Receptors  Transduction – conversion of environmental stimulus into action potential by sensory receptor  Receptors specific for particular type of stimulus  Specificity is due to structure of receptor

9 From Sensation to Perception  A stimulus is a change in the environment that is detected by a receptor  Sensation: the awareness of changes in the internal and external environment  Perception: the conscious interpretation of those stimuli

10 Classification by Location 1.Exteroceptors  Respond to stimuli arising outside the body  Receptors in the skin for touch, pressure, pain, and temperature  Most special sense organs 2.Interoceptors (visceroceptors)  Respond to stimuli arising in internal viscera and blood vessels  Sensitive to chemical changes, tissue stretch, and temperature changes

11 Classification by Location 3.Proprioceptors  Respond to stretch in skeletal muscles, tendons, joints, ligaments, and connective tissue coverings of bones and muscles  Inform the brain of one’s movements

12 12 Four types of General Sensory Receptors  Pain: nociceptor  Temperature: thermoreceptor  Physical: mechanoreceptor  Chemicals: chemoreceptors  All can be found in both somatic (exteroceptors) and visceral (interoceptors) locations except:  Proprioceptors (a mechanoreceptor) are somatic only  report the positions of skeletal muscles and joints

13 13 Pain Receptors: Nociceptors  (noci = harm) sensitive to pain-causing stimuli (e.g. extreme heat or cold, excessive pressure, inflammatory chemicals)  Free nerve ending  Mode of Action:  Injured cells release arachidonic acid  Arachidonic acid is converted into prostaglandins by the interstitial enzyme cyclo-oxygenase  Prostaglandins activate nociceptors -Many pain medications like aspirin function to inhibit cyclo-oxygenase -Pain levels are modulated by endorphins which inhibit CNS function

14 14 Thermoreceptors  Detect temperature  Found in skin, skeletal muscle, liver, and hypothalamus  Consist of free nerve endings  Phasic receptors that adapt easily  Cold response are more superficial and receptors that respond to heat – deeper  Temperature out of the range of the thermoreceptors will activate nociceptors

15 15 Mechanoreceptors  Detect membrane distortion  Three receptor types:  Tactile Receptors  Proprioceptors  Baroreceptors

16 16 Mechanoreceptors - Tactile Receptors  Detect touch, pressure and vibration on skin  Detect hair movement  Detect fine touch  Detect deep pressure  respond to itch (respond among other to histamine) and light touch (detect changes in shape like bending)

17 Receptor typeStructureLocationFunction Meissner’s corpuscle/tacti le corpuscle Few spiral terminals surrounded by CT capsule Between dermal papillae in hairless skin Touch, pressure Pacinian corpuscle/lame llated corpuscle Single dendrite surrounded by capsule with up to 60 layers of collagen fibers Skin, interosseous membrane, viscera Deep pressure. Respond only when the pressure is first applied (on/off pressure stimulation) Ruffini’s corpuscle Receptor endings enclosed by flatten capsule All skin, joint capsule Stretching of skin – continuous pressure

18 18 Mechanoreceptors - Proprioceptors  Detect positions of joints and muscles  Muscle spindles  Modified skeletal muscle cell  Monitor skeletal muscle length  Golgi tendon organs  Dendrites around collagen fibers at the muscle- tendon junction  Monitor skeletal muscle tension  Joint capsule receptors  -Monitor pressure, tension and movement in the joint

19 Receptor typeStructureLocationFunction Muscle spindles Spindle-shape proprioceptors. Modified skeletal muscle fibers enclosed in CT capsule Perimysium of skeletal muscles Detect muscle stretch and initiate reflex that resist stretch Golgi tendon organs Proprioceptors. Consist of bundle of collagen fibers enclosed in CT capsule with sensory endings coiling between and around the fibers In tendons close to skeletal muscle insertion When tendon fibers are stretched by muscle contraction the nerve endings are activated by compression. When activated, the contraction of the muscle is inhibited which causes relaxation Joint receptors Proprioceptors (combination of several receptors types – Pacinian, Raffini, free ending and Golgi tendon) Joints’ CT capsuleMonitor stretch in in the articular capsule and provide information on the position and motion of the joint (conscious)

20 20 Mechanoreceptors - Baroreceptors  Detect pressure changes  Found in elastic tissue of blood vessels and organs of digestive, reproductive and urinary tracts

21 21

22 22 Chemoreceptors  Detect change in concentration of specific chemicals or compounds  pH, CO2, sodium etc.  Found in respiratory centers of the brain and in large arteries

23 Table 10-2 Sensory Receptors

24 Processing of the sensory information  Levels of neural integration in sensory systems: 1.Receptor level — the sensor receptors 2.Circuit level — ascending pathways in the CNS 3.Perceptual level — neuronal circuits in the cerebral cortex

25 Figure Receptor level (sensory reception and transmission to CNS) Circuit level (processing in ascending pathways) Spinal cord Cerebellum Reticular formation Pons Muscle spindle Joint kinesthetic receptor Free nerve endings (pain, cold, warmth) Medulla Perceptual level (processing in cortical sensory centers) Motor cortex Somatosensory cortex Thalamus Processing at the Receptor Level

26  The receptor must have specificity for the stimulus energy (as previously discussed)  The receptor’s receptive field must be stimulated  The stimulus need to be converted to a nerve impulse  Receptors have different levels of adaptation  Information is encoded in the frequency of the stimuli – the greater the frequency, the stronger is the stimulus.

27 The stimulation of the receptive field affects the discharge of the sensory neurons  The receptive field is the a specific physical area that, when stimulated, affect the discharge of the stimulus.  Most receptive fields activation will result in message sending – excitatory receptive field  Sensory receptors in the CNS can have inhibitory receptive field (example: vision fields to determine borders).  Sensory neurons of neighboring receptive field may exhibit  Convergence many sub-threshold stimuli to sum in the postsynaptic neuron  Overlapping with another receptor’s receptive field – sending 2 sensations from the same area (pressure and pain)  The smaller the receptive field the greater the ability of the brain to localize the site

28 Figure 10-3a One signal goes to the brain. Compass with points separated by 20 mm Primary sensory neurons Skin surface Secondary sensory neurons (a) Sensory Neurons: Two-Point Discrimination  convergence Two- point discrimination

29 Two signals go to the brain. Compass with points separated by 20 mm Primary sensory neurons Skin surface Secondary sensory neurons (b) Figure 10-3b Sensory Neurons: Two-Point Discrimination - overlapping

30 Figure 10-2 The receptive fields of three primary sensory neurons overlap to form one large secondary receptive field. Primary sensory neurons Secondary sensory neuron SECTION THROUGH SPINAL CORD Information from the secondary receptive field goes to the brain. The primary sensory neurons converge on one secondary sensory neuron. Receptive Fields of Sensory Neurons - overlapping

31 Properties of Stimulus: Location  Lateral inhibition enhances contrast and makes a stimulus easier to perceive Figure 10-6 Stimulus Primary neuron response is proportional to stimulus strength. Pathway closest to the stimulus inhibits neighbors. Inhibition of lateral neurons enhances perception of stimulus. Tonic level ABC ABC Skin Pin Primary sensory neurons Secondary neurons Tertiary neurons ABC Frequency of action potentials

32 Transduction allows sensory receptors to respond to stimuli – converting sensation into a nerve impulse  Sensory transduction – the process that enables a sensory receptor to respond to a stimulus.  The sensory transduction induces a receptor potential in the peripheral terminal of the sensory neuron  A receptor potential is a depolarization event that if brings the membrane to a threshold, will become a nerve impulse (AP)  The conversion from receptor potential to AP happens in the trigger zone that can be in the first node of Ranvier.  In some cases, the peripheral terminal is a separate sensory cell (ex. Photo receptors). In this case there is an involvement of a synapse and NT

33 Receptors adaptation  The duration of a stimulus is coded by duration of action potentials.  A longer stimulus generates longer series of APs.  If a stimulus persists, some receptors adapt or stop responding  There are 2 classes of receptors according to how they adapt:  Tonic receptors – slowly adapting – they fire rapidly when first activated, than they slow and maintain firing as long as the stimulus is present (baroreceptors, proprioceptors)  Phasic receptors – rapidly adapting receptors – rapidly firing when first activated but stop firing if the strength of stimulus remains constant  This type of reaction allows the body to ignore information that was evaluated and found not to be a threat to homeostasis (smell)

34 Tonic Receptors Figure 10-8a  Always active  Signal at different rate when stimulated  Monitor background levels

35 Phasic Receptors Figure 10-8b  Activated by stimulus  Become active for a short time whenever a change occurs  Monitor intensity and rate of change of stimulus

36 Receptors adaptation  The mechanisms for receptors’ adaptation depends on the receptors:  Potassium channels in the receptor’s membrane open causing the membrane repolarization  Sodium channels inactivated stopping depolarization  Accessory structure may contribute to decrease sensitivity (muscle in the ear contract and limit the movement of the auditory oscicles)

37 Figure Receptor level (sensory reception and transmission to CNS) Circuit level (processing in ascending pathways) Spinal cord Cerebellum Reticular formation Pons Muscle spindle Joint kinesthetic receptor Free nerve endings (pain, cold, warmth) Medulla Perceptual level (processing in cortical sensory centers) Motor cortex Somatosensory cortex Thalamus Processing at the circuit Level

38  A sensory pathway is a set of neurons arranged in series.  The circuit level role is to deliver the impulses to the appropriate region in the cerebral cortex.  The ascending tract typically consists of 3 neurons  First order neurons  cell bodies in a ganglion (dorsal or cranial)  Impulses from skin and proprioceptors to spinal cord or brain stem to a 2 nd order neuron  Second order neuron  In the dorsal horn of the spinal cord or in the medulary nuclei  Transmit impulses to thalamus or cerebellum  Third order neurons  Cell bodies in the thalamus (no 3 rd -order neurons in the cerebellum)  Transmit signals to the somatosensory cortex of the cerebrum

39 Pathways for somatic perception  Receptors for the somatic sensations are found both in the skin and viscera  Receptor activation triggers AP in the 1 st order neuron  In the spinal cord, sensory neurons synapse with interneurons – 2 nd order neurons  All 2 nd order neurons cross over at some point (sensations are being integrated in the opposite side)  The synapse between the 2 nd and the 3 rd happens in the thalamus  The axons of the 3 rd order neurons project to the appropriate somatosensory area in the cerebral cortex

40 Processing at the circuit Level  Impulses ascend in :  Non specific pathway that in general transmit pain, temperature and touch  Give branches to reticular formation and thalamus on the way up  Sends general information that is also involved in emotional aspects of perception  Specific ascending pathways involve in more precise aspect of sensation

41 Thalamic Function  The thalamus is the “gateway to the cerebral cortex”  Major relay station for most sensory impulses that arrive to the primary sensory areas in the cerebral cortex:  taste, smell, hearing, equilibrium, vision, touch, pain, pressure, temperature  Contributes to motor functions by transmitting information from the cerebellum and basal ganglia to the cerebral primary motor area  Connects areas of the cerebrum  Impulses of similar function are sorted out, edited, and relayed as a group

42 3 major somatosensory pathways –1) spinothalamic pathway  Conscious sensation of poorly localized sensations  Anterior spinothalamic tracts – crude touch and pressure  Lateral spinothalamic tracts – pain and temperature  1 st order neurons synapse with the 2 nd in the posterior gray horn at the level of entrance  The 2 nd cross before ascending to the thalamus  3 rd order synapse at the level of the primary somatosensory cortex


44 3 major somatosensory pathways - 2) Posterior column pathway  Sensation of precise touch, vibration and proprioception  Includes  Left and right fasciculus gracilis (inferior part of the body)  Left and right fasciculus cuneatus (superior part of the body)  First order neurons enter the CNS at the dorsal roots and the sensory roots of cranial nerves.  Synapse with 2 nd order in the medulla  2 nd order neurons cross over in the brain stem  3 rd order in the thalamus where the stimuli are sorted by the nature of stimulus and the region of body involved


46 3 major somatosensory pathways – 3) The spinocerebellar pathway  Information about muscle, tendon and joint position from the spine to the cerebellum  This information is subconscious  1 st order neurons synapse in the dorsal horn  2 nd order neurons ascend via anterior and posterior spinocerebellar tracts to the cerebellar cortex  Used to coordinate movements  In this pathway there is no 3 rd order neuron


48 PathwaySensation1 st order2 nd order3 rd orderFinal destination Spinothalamic pathway Lateral spinothalamic Pain and temperature Dorsal root ganglion Posterior hornThalamus Primary sensory cortex (opposite side) Anterior spinothalamic Crude touch and pressure Dorsal root ganglion Posterior hornThalamus Primary sensory cortex (opposite side) Posterior column pathway Fasciculus gracilis Proprioception, fine touch and pressure from inferior half of the body Dorsal root ganglion Medulla oblongata Thalamus Primary sensory cortex (opposite side) Fasciculus cuneatus Proprioception, fine touch and pressure from superior half of the body Dorsal root ganglion Medulla oblongata Thalamus Primary sensory cortex (opposite side) Spinocerebellar pathway Anterior and posterior ProprioceptionDorsal root ganglion Posterior hornNot presentCerebellar cortex

49 Fine touch, proprioception, vibration Nociception, temperature, coarse touch SPINAL CORD MEDULLA THALAMUS Pain, temperature, and coarse touch cross the midline in the spinal cord. Fine touch, vibration, and proprioception pathways cross the midline in the medulla. Sensations are perceived in the primary somatic sensory cortex. Sensory pathways synapse in the thalamus. Primary sensory neuron Secondary sensory neuron Tertiary neuron KEY Somatic Senses Pathways Figure 10-9, steps 1–4

50 Figure Receptor level (sensory reception and transmission to CNS) Circuit level (processing in ascending pathways) Spinal cord Cerebellum Reticular formation Pons Muscle spindle Joint kinesthetic receptor Free nerve endings (pain, cold, warmth) Medulla Perceptual level (processing in cortical sensory centers) Motor cortex Somatosensory cortex Thalamus Processing at the Perceptual Level

51  Interpretation of sensory input occurs in the cerebral cortex  The ability to identify the sensation depends on the specific location of the target neurons in the sensory cortex not on the nature of the message (all messages are action potentials)

52 The CNS integrate sensory information  Most of the somatic sensory information enters the spinal cord and travels via ascending pathways to the brain  Some information goes directly to the brain through the cranial nerves  Autonomic sensory information does not arrive conscious perception

53 Main Aspects of Sensory Perception  Perceptual detection – detecting that a stimulus has occurred and requires summation  Magnitude estimation – the ability to detect how intense the stimulus is  Spatial discrimination – identifying the site or pattern of the stimulus  Feature abstraction – used to identify a substance that has specific texture or shape  Quality discrimination – the ability to identify submodalities of a sensation (e.g., sweet or sour tastes)  Pattern recognition – ability to recognize patterns in stimuli (e.g., melody, familiar face)

54 Somatosensation perception  The specific sensation depends on the 2 nd and 3 rd neurons  The ability to localize the specific location of a stimulus depends on the stimulation of a specific area in the primary somatosensory cortex  A sensory “homunculus” (little human) is a functional map of the primary somatosensory cortex

55 Somatosensory Association Cortex  Located posterior to the primary somatosensory cortex and has connection with it  Integrates sensory information like temperature and pressure coming from the primary somatosensory cortex.  Forms understanding of the stimulus like size, texture, and relationship of parts  Ex.: putting the hand in the pocket and feeling something. The center integrate previous information to identify objects without seeing them

56 The main Sensory Areas in the cerebral cortex Figure 12.8a

57 Properties of the sensory system - summary  Stimulus – works on a receptor  The receptor is a transducer that converts the stimulus into a change of membrane potential  The message from the receptor will be sent in the form of action potential to the CNS  Stimuli that will reach the cerebral cortex will be come conscious  Somatosensory information ascends the spinal column along several pathways, which synapse at the midbrain &/or thalamus before reaching the cortex  Sensory processes have different sub-modalities of somatosensory information  Later stages of processing combine information across the sub- modalities, & with information from other senses

58 Pain pathways  Pain is a protective mechanism  Pain is a subjective perception  It is individual and can vary depending on emotional state  Types of pain sensations:  Fast pain – sharp and localized – in superficial parts of the body (cut, burn)  Rapidly transferred to CNS by small myelinated fibers (within 0.1 seconds after stimulus applied)  Slow pain – more diffused pain (associated with tissue destruction)  Carried by small unmyelinated fibers  Often fast pain will follow a slow one

59 Pain pathways  Pain from the body – via spinal cord  Pain from face – via trigeminal (V) that enters the pons, descend to the medulla where they cross over and ascend to the thalamus  The ascending pathway sends branches not only to thalamus and the cerebral cortex but also to the limbic system (emotions) and hypothalamus (autonomic reaction)  The result is that pain may be accompanied by emotional distress and autonomic reactions such as nausea, vomiting or sweating

60 Pain perception  Pain can be felt in skeletal muscle when anaerobic metabolism  In cardiac muscle, pain is a result of ischemia (lack of oxygen due to reduced blood flow) during myocardial infraction (heart attack)  Visceral pain is poorly localized and called referred pain

61 Pain perception – the gate control theory  Pain perception is subjected to modulation that can happen in several levels of the nervous system  Pain can be magnified by past experiences  Pain can be suppressed when in emergencies when surviving depends on ignoring the injury   (minute 13.41)

62 The Gate-Control Theory of Pain Figure 10-12a  Pain can be suppressed in the dorsal horn level.  Normally, tonically active inhibitory interneuron inhibit ascending pathways for pain

63 The Gate Control Theory of Pain Modulation Figure 10-12b  Fibers from nociceptors synapse on the inhibition interneuron  When activated, the fibers send message to block the interneurons and pain travels to the brain

64 The Gate Control Theory of Pain Modulation Figure 10-12c  In the gate control theory of pain modulation fibers carrying sensory information about mechanical stimuli help block pain transmission  Those fibers synapse on the interneuron and increase its inhibitory activity  If both pain stimulus and nonpainful stimulus arrive at the same time, there will be partial inhibition of pain  The sensation of pain will be perceived by the brain as lower  Explains why rubbing a bumped elbow lessens the pain feeling

65 Visceral sensory pain pathways  Collected by interoceptors within the closed ventral body cavities  The interoceptors include nociceptors, thermoreceptors, tactile receptors, baroreceptors and chemoreceptors  The axons of the 1 st order neuron usually travel with the autonomic motor fibers innervating the same visceral structures  2 nd order neurons within the spinal cord use the spinothalamic pathway and arrive to the medulla oblongata  Cranial nerves V, VII, IX and X carry visceral sensory information also to the medulla  (all parasympathetic will be discussed with the ANS)

66 Referred Pain Figure 10-13b Skin (usual stimulus) Kidney (uncommon stimulus) Primary sensory neurons Secondary sensory neuron Ascending sensory path to somatosensory cortex of brain (b)

67 Sensory Pathways Figure Olfactory pathways from the nose project through the olfactory bulb to the olfactory cortex. Equilibrium pathways project primarily to the cerebellum. Most sensory pathways project to the thalamus. The thalamus modifies and relays information to cortical centers. Eye Nose Tongue Equilibrium Sound Brain stem Visual cortex Auditory cortex Gustatory cortex Primary somatic sensory cortex Olfactory cortex Olfactory bulb Cerebellum Thalamus Somatic senses

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