Presentation on theme: "SEMISOLID DOSAGE FORMS AEROSOLS PRESCRIPTION WRITING"— Presentation transcript:
1 SEMISOLID DOSAGE FORMS AEROSOLS PRESCRIPTION WRITING Department of Pharmacology & ToxicologyMedical Faculty, Medical University – SofiaDr. Rumen Nikolov, PhDSEMISOLID DOSAGE FORMSAEROSOLSPRESCRIPTION WRITING
2 Vehicles (bases)A vehicle is defined as the inert carrier of the active ingredientLipophilic base: paraffin oil, petroleum jelly, wool fat (lanolin)A lipophilic drug moves more readily into the epidermis if it is in an aqueous vehicle (to which it is less tightly bound)
3 The main rule of the local therapy is: if the skin is dry, use an ointment; if it is wet, use a cream.Dry, chronic inflammation often improves more with drugs administered in lipophilic vehicles, whereas moist acute inflammation is best treated with aqueous preparations.
5 OintmentsOintments are greases with the permissible addition of up to 25% of powder by weight.According the place of application they are:1) unguentum dermaticum2) unguentum ophthalmicum3) unguentum nasaleOintments are useful in any conditioncharacterized by dry skin (e.g. atopic dermatitis).
6 Pastes are greases containing more than 25% powder by weight They are useful for dry surfacesPastes are very difficult to remove
7 19. OINTMENTS19. A) Prescribe 2,5 g Nemybacin inthe form of eye ointment.Rp/ Ung. ophth. Nemybacini 2,5 gD. tub. № 1S. Apply in the lower conjunctival sac of the affected eye twice daily.
8 D. S. Apply to the affected skin 19b) Prescribe 30 g ointment, containing 2 g Salicylic acid and 4 g Benzoic acid.Rp/ Acidi salicylici 2 gAcidi benzoici gVaselini albi ad 30 gM. f. unguentumD. S. Apply to the affected skintwice daily.An ointment containing Benzoic acid and Salicylicacid in a ratio of 2:1 is calls Whitfield’s ointment.It is used mainly in the treatment of tinea pedis.
9 Rp/ Pasta Zinci 100 g D. S. Apply to the burned 20) Prescribe 100 g officinal paste, containing Zinc.Rp/ Pasta Zinci 100 gD. S. Apply to the burnedareas once daily
10 Creams These are either oil-in-water (O/W) or water-in-oil (W/O) emulsions and containpreservatives to prevent bacterial andfungal growthThe commonest preservatives areparabensOil-in-water emulsions rub into the skinand are easily washed offWater-in-oil emulsions are greasier
11 Gels Gels are semi-colloids which liquefy on contact with the skin For use on the scalp and face gels orlotion are acceptableGels are a common form for acnepreparations (e. g. Acnederm)
12 S. Apply to the affected skin 21. Cream and gel21a) Prescribe Lamisil (1% 15 g) as officinal cream.Rp/ Creme Lamisili 1% 15 gD. tub. №1S. Apply to the affected skinareas twice daily.
13 S. Apply to the affected area 21b) Prescribe Troxevasin 2% 40 g as gelRp/ Gel Troxevasini 2% 40 gD. tub. № 1S. Apply to the affected areatwice daily.
14 SuppositoriesRectal suppositories – they can be produced a local (to treat haemorrhiods and ulcerative colitis) or systemic effects (for example anti-emetic effect)Vaginal suppositories – they are produced a local antimicrobial effect(e. g. Flagyl, Canesten Gyn 3)
15 Rp/ Supp. Paracetamoli 150 mg D. scat. № 1 22. Suppositories22a) Prescribe Paracetamol assuppositories each of 150 mg.Rp/ Supp. Paracetamoli 150 mgD. scat. № 1S. Insert 1 supp. in rectum 3 timesdaily.
16 Rp/ Supp. Ultraprocti D. scat. № 1 S. Insert 1 supp. in rectum 22. Suppositories.22b) Prescribe Ultraproct as officinal suppositories.Rp/ Supp. UltraproctiD. scat. № 1S. Insert 1 supp. in rectumonce daily.
18 S. Stick 1 plaster of the skin once daily. 23.) Prescribe Fentanyl TTS50 mcg/h (10 numbers).Rp/ Fentanyl TTS 50 mcg/hD.t.d. № 10S. Stick 1 plaster of the skin once daily.
19 Aerosols Most drug are intended for inhalation are administered by a pressurized aerosolor, less frequently, a powder inhaler.Aerosols for oral inhalation1. Metered-dose inhaler (e. g. 250 µg/puff)2. Spacers – is a large volume chamber that isattached to the metered-dose inhaler usedto decrease the deposition of drug in the mouthNasal aerosols (e.g. Olynth, Flixonase)Aerosols for external application
20 Rp/ Flixonase nasal 0,05% 100 g D. t. d. № 1 in flac. 24. Aerosols.24a) Prescribe 100 g 0,05% Fluticasone as an officinal nasal aerosol.Rp/ Flixonase nasal 0,05% 100 gD. t. d. № 1 in flac.S. 1-2 sprays/nostril/d.
21 Rp/ Fl. Ventolini 0,1 mg/dose D. t. d. № 1 S. One puff in the mouth. 24b) Prescribe one vial Salbutamol as an officinal aerosol (Ventolin 0,1 mg/dose).Rp/ Fl. Ventolini 0,1 mg/doseD. t. d. № 1S. One puff in the mouth.