Presentation on theme: "Creating a virtuous cyclepath through the valley of death"— Presentation transcript:
1Creating a virtuous cyclepath through the valley of death Professor Warwick Anderson AMCEO, NHMRC
2Research Virtuous Cycle Focus on innovative industries, pharmaceutical industry invested approximately $1billion in Research and Development, pharmaceutical industry earned $4billion in exports
3Leadership role in research translation NHMRC Strategic PlanLeadership role in research translationContinued support of research translation through funding schemesCentres of Research ExcellencePartnership Centres for Better HealthPractitioner FellowshipsDevelopment GrantsResearch Translation Faculty
4Research Translation Faculty Newly established Faculty with more than 2,500 NHMRC funded researchersIdentify the major evidence - practice gaps in NHMRC’s “Major Health Issues”, andDevelop a “Case for Action”, on how NHMRC can address the gapAdvice to governmentClinical or public health guidelinesTransformative research through a Targeted Call for Research .
5Development GrantsSupport research at the early proof-of-principle or pre-seed stageSince 2003:855 applications received206 projects funded worth approximately $53 millionYearExpenditure on Development Grants
6Development Grants Grants are becoming increasingly competitive 2006: 32.4% successful, 2011: 16.3% successfulAggregate Applications 2003 to 2012Administering Institution# of apps# of grantsfunded rateGrand Total85520624.1%University of Queensland832428.9%Monash University691724.6%University of Western Australia661624.2%University of Melbourne641523.4%Baker IDI Heart and Diabetes Institute251248.0%University of Adelaide4924.5%University of Sydney631117.5%Walter and Eliza Hall Institute3135.5%University of Wollongong21942.9%Queensland University of Technology733.3%University of New South Wales40Australian National University22627.3%Macfarlane Burnet Institute for Medical Research and Public Health18Murdoch Children's Research Institute2030.0%Garvan Institute of Medical Research425.0%Ludwig Institute for Cancer Research100.0%University of South Australia1428.6%Centre for Eye Research Australia Ltd350.0%La Trobe UniversityQueensland Institute of Medical Research17.6%Royal Melbourne Institute of Technology1323.1%Swinburne University of TechnologyBionic Ear Institute266.7%Flinders University267.7%Royal North Shore Hospital
7Development Grant success stories Professor Timothy St PierreUniversity of Western Australia: $341,210Non-invasive measurement and imaging of hepatic iron concentrations using nuclear magnetic resonanceLaunch of FerriScan in 2004Professor Ted MaddessAustralian National University2006: $113,487Wireless objective visual field testing for glaucoma diagnosisProduct went to market in 2010
8Development Grant success stories Professor Zee UptonQueensland University of Technology: $156,871Pre-clinical evaluation and optimisation of a novel therapy for burnsSales commence in Europe in 2012Professor Sarah RobertsonUniversity of Adelaide: $481,980GM-CSF regulation of pre-implantation embryo developmentProduct went to market in 2011
9The Valley of DeathNot all of the research from the 206 Development Grants will make it across the bridgeNature (2008) 453:How to improve the safety of the bridge across the Valley of Death?
10ACIG Evaluation of Development Grants Scheme Commissioned an independent assessment of the economic, health and industry outcomes from the NHMRC investment in the Development Grants scheme40 completed grants surveyed:85% reached complete or partial proof of concept at grant completion80% secured a commercial partner55% are currently under some form of commercial development6 have resulted in a product to market or awaiting regulatory approval
11ACIG Evaluation of Development Grants Scheme Recommendations:Scheme design to be retained unless there are other reasons for restructureGreater consultation with investors and industry on incorporation of commercial milestones in grant reportingConsultation with Commercialisation Australia and other appropriate agenciesDevelop and publicise successful case studies
12Other considerations: NHMRC Medical Research Endowment AccountIntellectual Property ReviewClinical TrialsStrategic Review of Health and Medical Research (McKeon Review)“Fiscal Rectitude”Australia in the Asian Century White Paper
13NHMRC Medical Research Endowment Account Purpose of the account is to provide assistance:To foster medical research and training and public health research and training throughout AustraliaNational Health and Medical Research Council Act 1992
14Intellectual Property Review Report on Collaborations between the Public and Private Sectors: The Role of Intellectual Property, September 2012Recommended:Adjusting key performance indicators for publicly funded research organisations (PFROs) to give greater incentives for industry collaborationIncrease project management skills in PFROsHelping small business to better engage with public researchersDe-risking early stage intellectual property
15Clinical TrialsEssential component of the research translation processAustralia facing increasing competition from:Developing economies in our regionDeveloped economies due to the high value of the $AUDClinical Trials Action GroupRecommendations provide the roadmap to build clinical trial activity in Australia
16Clinical Trials NHMRC launched the clinical trials website in October NHMRC will establish a working group to develop the interactive web portalStanding Council on Health agreed that a national approach to ethical review and approval of clinical trials will be implemented by June 2013NHMRC has developed documents and guidance material to support this transition and been actively involved
17Strategic Review of Health and Medical Research (McKeon Review) NHMRC submissionDraft recommendations:Enhancing the commercial pathway to impact, through increased funding of early stage product developmentFacilitating the exchange between research and industry and improve access to scale commercialisation services
18Fiscal Rectitude Dr Martin Parkinson, Treasury Secretary Nation’s taxation base is weaker than forecast in the mid-2000sCommonwealth tax receipts are expected to remain approximately $20 billion per annum lower than pre-GFC projectionsClosing this gap would require governments to raise more revenue and achieve significant savings“The public will need to make thoughtful decisions about what it wants government to provide, and how it expects these things will be provided”.
19Australia in the Asian Century White Paper Health and medical research sector has been missedNHMRC has been developing links with the Asia-Pacific regionGlobal HealthGACD call for research on hypertensionprevention in low to middle income countriesIs a strategic priority area in the Project GrantSchemePrevious tripartite with NZHRC and WellcomeTrustCollaboration with A*STARForum on H5N1 pandemic preparedness
20What will the cyclepath through the Valley of Death look like?