51 Conclusion KELLER for reverse engineering “rewiring” networks Key advantages: Computationally efficient (scalable to 10 4 genes) Computationally efficient (scalable to 10 4 genes) Global optimal solution is attainable Global optimal solution is attainable Theoretical guarantee Theoretical guarantee Glimpse to temporal evolution of gene networks Many interactions are rewiring and transient Availability: http://www.sailing.cs.cmu.edu/
52 The End Thanks Travel fellowship: Office of Science (BER), U.S. Department of Energy, Grant No. DE-FG02-06ED64270 Funding: Lane Fellowship, Questions?
53 Interactivity of Gene Sets 30 genes based on ontology
55 Challenges Very small sample size Experimental data are scarce and costly Noisy measurement More genes than microarrays Complexity regularization needed to avoid over- fitting Observations no longer iid since the networks are changing!