Presentation on theme: "EPIDEMIC CEREBROSPINAL MENINGITIS"— Presentation transcript:
1EPIDEMIC CEREBROSPINAL MENINGITIS Dept. Of Infectious DiseaseShengjing Hospital
2DEFINITION1. Epidemic cerebrospinal meningitis is acute infectious disease caused bymeningococcus.2.characteristics of ECM are fever,headache, vomiting , petechiae or ecchymosis , and meningeal irritation signs. CSF is purulent .
3ETIOLOGY1.Pathogen is Neisseria meningitidis (meningococcus); G diplococcus.2.Biological features:2.1.The organism grow by incubationon blood,chocolate or trypticase soy agar in 5~10%CO2,PH 7.4~7.6;2.2.The organism is susceptible to dry,heat , chill and disinfectant;
5ETIOLOGY 2.3. autolysis by autolysin in vitro; 3.The organism can be detected in patient’s nasopharynx, blood, CSF, petechiae in skin;4.Pathogenic factor: endotoxin.
6ETIOLOGY 5.Serogroups of meningoccus; 13 serogroups and more than serotypes found in the world;most common serogroups:A B C groupGroup A is the most common in china.
7EPIDEMIOLOGY 1.Source of infection: patients and carriers; 2.The routes of transmission :1) air borne2) closed contact transmission :3.Susceptibility of population: universal susceptiblestable and persistent immunity
8EPIDEMIOLOGY 4.Epidemiologic feature: (1). Season: November - May high peak: March - April(2).age: 6 months to 2 years old
17CLINICAL MANIFESTATION 3.2.CNS symptoms:headache,vomiting,meningeal irritation:nuchal rigidity;Kerning’signs andBrudzinski’signs are positive.severe case :drowsiness,delirium, and restless merge into coma.Convulsions may occur at any stageof the illness.4.Convalescent stage:5~7days from