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Spotlight On Dr. Mohammad El-Tahlawi
2 nd most abundant intracellular cation. Cofactor > 300 ATP enzymatic reaction. Excitable tissues. * Ca ++ movement. Heart Vascular tone
Adult body g > 50% bone > 45% muscle 0.7% RBCs 0.3% plasma
0.3% plasma mEq/L 55 % ionized ( active ) 45 % Non - ionized 33 % Protein bound 12 % chelated
Urinary Mg mEq / 24 hr
Transcellular transport. Intestinal absorption. Renal Excretion. Hormonal Modulation. Body’s “Orphan” ion
Hypomagnesaemia Mg level <1.5 mEq/L
Drugs Furosemide 50 % Aminoglycosides 30 % Amphotericin Digitalis 20 % Cisplatin, Cyclosporine
Diarrhea ( Secretory )
Associated Electrolyte Abnormalities Hypokalaemia. Hypocalcemia. Hypophosphatemia. Refractory
Mg and Stroke Neuroprotective. Reactive Central Nervous System Mg Deficiency.
Mg and AMI Mg Infusion Prior to In parallel with thrombolytic agent
Mg and Arrhythmia Atrial Ventricular ECG: prolonged QT, PR intervals
Mg & & Atherosclerosis
Mg & & Bronchial asthma
Mg Retention Test. Predisposing Factors. Refractory Electrolyte disor.
MgSO 4 1 gm = 8 mEq = 4 mmol
1 mEq / Kg 1st day Mild Mg Deficiency 0.5 mEq / Kg / day 3 days Oral Mg.
48 mEq over 3 hrs Moderate Deficiency 40 mEq over next 6 hrs 40 mEq / 12 hrs 5 days
16 mEq over 2 min. Life - threatening 40 mEq over next 6 hrs. 40 mEq / 12 hrs 5 days.
Mg and ICU 65% Adult ICU. 30% Neonatal ICU. 10% General hosp. Patients.
Mg The most underdiagnosed electrolyte abnormality in current medical practice.
Joe Pistack MS/ED. Intracellular-water located in all the cells of the body. About 63% of the water is located in the intracellular compartments.
Calcium & phosphorus. Calcium Physiology Distribution – Fifth element, main cation, kg, 99%, 1%, 1%. – Forms (plasma) Free,50% Complexed with anions,10%
Part 2 Electrolytes. Bicarbonate 2 nd most abundant anion of ECF. Major component of the HCO 3 - /H 2 CO 3 buffering system. Serves as a transport form.
Body fluids Electrolytes. Electrolytes form IONS when in H2O (ions are electrically charged particles) (Non electrolytes are substances which do not split.
MLAB 2401: Clinical Chemistry Keri Brophy-Martinez Overview: Mineral and Bone Metabolism.
Fluid, Electrolyte and Acid-Base Balance Dr. Carlene Graham.
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DPT IPMR KMU Dr. Rida Shabbir. K+ extracellular 4.2 mEq/L Increase in conc to 3-4 mEq/L causes cardiac arrhythmias causing cardiac arrest and fibrilation.
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Calcium, Phosphorus, Magnesium and Related Disorders (By Basil OM Saleh) Objective: 1. Calcium & Phosphorus homeostasis, Hypercalcaemia, and Hypocalcaemia.
2009 Cengage-Wadsworth Chapter 11 Macrominerals.
Calcium & Inorganic phosphate. Calcium Physiological function : Bone mineralization Blood coagulation Important in muscle contraction Affecting enzyme.
The Structure of the Cardiovascular System General introduction.
Fluid, Electrolyte and Acid Base Balance Integrating Respiratory, Urinary and Digestive Physiology.
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( Source, Release & Function ) 1.structure of bone & teeth 6. hormone secretion 5. hormonal actions 2.neurotransmission 4. muscle contraction 3. blood.
By Dr. Sana Fatima Instructor, Biochemistry Department.
Function of Circulation SBI 3U1. Mammalian Circulatory System Mammals tend to have a complex body system with high energy demand. Thus the circulatory.
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How it works….step by step: At rest, the inside of the neuron is slightly negative due to a higher concentration of positively charged sodium ions outside.
Parathyroid hormone, Calcitonin,Calcium, and Phosphate Metabolism, VitaminD.
Principals of fluids and electrolytes management Ram Elazary, MD General Surgery Department Hadassah Hebrew University Medical Center Campus Ein-Kerem,
PHYSIOLOGY OF WATER- ELECTROLYTES BALANCE. Total body water in adult human % %
Prof. Hanan Hagar Pharmacology Department. What student should know Major body fluid compartments Concept of compartments. Apparent volume of distribution.
CONTROL OF EXTRACELLULAR FLUID VOLUME AND REGULATION OF RENAL NaCL EXCRETION.
Prof. Hanan Hagar Pharmacology Department. By the end of the lectures, students should be able to define the following: Major body fluid compartments.
By Amr S. Moustafa, M.D., Ph.D. Ass. Prof. & Consultant Clinical Biochemistry & Molecular Biology College of Medicine and Obesity Research Center King.
General Introduction Excretory Organs Lungs Liver Skin Kidneys.
MAJOR CHEMICAL COMPONENTS OF THE LIVING ORGANISMS Medical Biochemistry Molecular Principles of Structural Organization of Cells.
Fluid and Electrolyte Balance Muse Lecture #10 3/23/11.
Calcium Homeostasis Dr Taha Sadig Ahmed. Physiological Importance of Calcium Calcium salts in bone provide structural integrity of the skeleton Calcium.
Slide 1 Mosby items and derived items © 2012 by Mosby, Inc., an affiliate of Elsevier Inc. Chapter 18 Fluid and Electrolyte Balance.
WATER, ELECTROLYTE AND ACID/BASE BALANCE CHAPTER 21.
Calcium Homeostasis Dr Taha Sadig Ahmed. Physiological Importance of Calcium Calcium is essential for normal (1) structural integrity of bone and teeth.
TUBULAR REABSORPTION Dr. Shaikh Mujeeb Ahmed Assistant Professor AlMaarefa College URINARY BLOCK 313.
Structures – bones made of living cells, protein fibers and calcium.
PhD. Halina Falfushynska. Manganese is obtained mainly from the mineral pyrolusite, MnO 2. Ferromanganese alloys are wear resistant and shock resistant.
Got Calcium? Ca 2+. Plasma Calcium Regulation Plasma calcium totals 2.4 mM (9.4 mg/dl) –Free calcium is 1.2 mM.
INTRODUCTION INTO ANATOMY & HOMEOSTASIS THE BOYZ.
Tissues, Organ Systems and Homeostasis Dr. A. Russo-Neustadt Biology 155.
1. Describe the method for measurement of membrane potential 2. Define resting membrane potential. 3. Discuss the ionic basis of resting membrane potential.
1 Pharmacology Pharmacokinetics –Absorption –Distribution –Biotransformation (metabolism) –Excretion Pharmacodynamics –Receptor binding –Signal transduction.
Calcium and its significance in the bone metabolism Romana Šlamberová, MD PhD Department of Normal, Pathological and Clinical Physiology.
Elsevier items and derived items © 2010, 2006, 2002 by Saunders, an imprint of Elsevier Inc. Chapter 13 Assessment and Care of Patients with Fluid and.
صدق الله العظيم الاسراء اية 85. By Dr. Abdel Aziz M. Hussein Assist Prof of Medical Physiology.
A Mathematical Model of Metabolism for Diabetes Dayu Lv Advisor: Dr. Goodwine.
1 Fluid and Electrolyte Imbalances. 2 3 Body Fluid Compartments 2/3 (65%) of TBW is intracellular (ICF) 1/3 extracellular water –25 % interstitial fluid.
Metabolism (the sum of all the chemical processes that occur in the human body there are 2 phases catabolism anabolism) Movement (includes motion of the.
1 Lecture-5 Dr. Zahoor. Objectives – Tubular Secretion Define tubular secretion Role of tubular secretion in maintaining K + conc. Mechanisms of tubular.
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