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Spotlight On Dr. Mohammad El-Tahlawi
2 nd most abundant intracellular cation. Cofactor > 300 ATP enzymatic reaction. Excitable tissues. * Ca ++ movement. Heart Vascular tone
Adult body g > 50% bone > 45% muscle 0.7% RBCs 0.3% plasma
0.3% plasma mEq/L 55 % ionized ( active ) 45 % Non - ionized 33 % Protein bound 12 % chelated
Urinary Mg mEq / 24 hr
Transcellular transport. Intestinal absorption. Renal Excretion. Hormonal Modulation. Body’s “Orphan” ion
Hypomagnesaemia Mg level <1.5 mEq/L
Drugs Furosemide 50 % Aminoglycosides 30 % Amphotericin Digitalis 20 % Cisplatin, Cyclosporine
Diarrhea ( Secretory )
Associated Electrolyte Abnormalities Hypokalaemia. Hypocalcemia. Hypophosphatemia. Refractory
Mg and Stroke Neuroprotective. Reactive Central Nervous System Mg Deficiency.
Mg and AMI Mg Infusion Prior to In parallel with thrombolytic agent
Mg and Arrhythmia Atrial Ventricular ECG: prolonged QT, PR intervals
Mg & & Atherosclerosis
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Mg Retention Test. Predisposing Factors. Refractory Electrolyte disor.
MgSO 4 1 gm = 8 mEq = 4 mmol
1 mEq / Kg 1st day Mild Mg Deficiency 0.5 mEq / Kg / day 3 days Oral Mg.
48 mEq over 3 hrs Moderate Deficiency 40 mEq over next 6 hrs 40 mEq / 12 hrs 5 days
16 mEq over 2 min. Life - threatening 40 mEq over next 6 hrs. 40 mEq / 12 hrs 5 days.
Mg and ICU 65% Adult ICU. 30% Neonatal ICU. 10% General hosp. Patients.
Mg The most underdiagnosed electrolyte abnormality in current medical practice.
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ACID – BASE BALANCE HOMEOSTASIS Relative [ ] of hydrogen ions pH – potential hydrogen Normal pH: 7.35 – 7.45 <7.35 is acidosis >7.45 is alkalosis.
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Ta bl e of co nt en ts 1. Skeletal sysytem s 2.Muscu lar system 3.Nervo us system 4.Respir atory systems 5.Cardio vascular sysytem s 6.Lymph atic systems.
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