Presentation on theme: "Role of Ultrasound In Renal Transplantation"— Presentation transcript:
1Role of Ultrasound In Renal Transplantation Dr. Ahmed RefaeyConsultant RadiologistPrince Sultan Military Medical City
2Ultrasound is often the initial diagnostic modality as it is noninvasive, relatively inexpensive, does not require intravenous contrast, can be obtained at the bedside, and can often rapidly and accurately depict many of the common complications
4Knowledge of the exact renal transplant procedure performed is essential for accurate interpretation of both normal and abnormal findings. Particularly important is knowledge of the vascular anatomy, so that all vessels and anastomoses can be evaluated for patency, stenosis or other complications.
5* Vascular supply from end-to-side anastomosis of donor artery and vein to external iliac artery and vein. If multiple arteries, usually joined with single anastomosis to EIA or can be anastomosed separately to the external iliac arteryUreter anastomosed tosuperolateral wall ofurinary bladder
6The transplanted kidney is usually placed in an extraperitoneal location in the right or left iliac fossaThe superficial location makes it ideal for US evaluation.
8Normal color doppler findings : - arteries : brisk upstroke, low resistance with normal RI of 0.6 – 0.75- normal velocity of main renal artery < 200 cm/s- veins : may be monophasic with continous flow, or demonstrate some pulsatility with cardiac cycle.
16found in ≤50% of renal transplants. The clinical relevance of a fluid collection depends on its composition, size, location and whether or not it is exerting mass effect on the transplant kidney, ureter or other adjacent structuresMass effect from perinephric fluid can result in:-hydronephrosis-kinking of the vascular pedicle-edema of the leg, abdominal wall, labia or scrotum.
17Hematoma- often present in the immediate postoperative period ≤2 weeks after surgery- usually located either in the subcutaneous tissue , or around the transplant- the sonographic characteristics vary with age- acute and chronic hematoma : echogenic- intermediate hematoma: fluid filled, internal septations.
19Urinoma- often present in the immediate postoperative period ≤2 weeks after surgery- serious complication, usually caused by a defect in the uretrovesical anastmosis- appear as well-defined anechoic collections without septations, unless infected or mixed with blood
21Lymphocele- a more delayed complication, occurring 4 to 8 weeks after surgery- usually located between the bladder and the kidney- cystic, but a majority tend to have septations- due to disruption of the adjacent lymphatic channels
24Abscessuncommon, but can occur in the early postoperative period due to pyelonephritis or bacterial seeding of a urinoma, hematoma or lymphoceleSuspected when the patients presents with fever and increased WBCsSonographically, can vary from an echo-free to complex echopattern.
27HydronephrosisEither due to extrinsic compression ( perinephric fluid collection )or due to renal calculi, clot, anastomotic edema and ureteral stenosis .It should be noted that anastomotic edema often results in transient hydronephrosis of the transplanted kidney.Also, apparent hydronephrosis may be the result of an increased hydrostatic pressure due to a full bladder; evaluation after voiding can avoid diagnostic error in this setting.
35RejectionHyperacute rejection : no role since the diagnosis is typically made immediately after transplant while still in the operating room
36Acute rejection- Acute rejection takes several days to develop and peaks at 1 to 3 weeks after transplant- findings have been shown to be unreliable in its diagnosis. In cases of severe acute rejection, the transplanted kidney becomes edematous , globular, hypoechoic mass with poor differentiation of the central renal sinus fat with elevation of the resistive index
37Acute transplant rejection Enlarged, globular, hypoechoic renal transplant with loss of the normal corticomedullary differentiation and ill definition of renal sinus fat due to severe edema
38Acute rejectionSpectral doppler image of a segmental artery reveals a mildly increased resistive index due to parenchymal edema
40Chronic rejection- most common cause of late graft loss- begins 3 months after the transplantation.- US: cortical thinning , mild hydronephrosis , prominent sinus fat, dystrophic calcification, decreased color, normal or increased RI.
42Acute tubular necrosis More common than rejectionLittle sonographic change in parenchyma pattern.ATN occurs in the immediate post transplant period as a result of ischemia, thus more commonly seen in cadaveric transplants
44In summary, most cases of functional complications have non-specific imaging findings consisting of parenchymal edema and elevated resistive indices and require tissue analysis with renal biopsy for diagnosis.
51Renal vein thrombosis more common than renal artery thrombosis typically occurs between the third and eighth days post transplantPossible etiologies include poor surgical technique, compression of the renal vein by a fluid collection or hypovolemia
52On US, The kidney may appear enlarged and hypoechoic with lack of Doppler signal in the renal vein. The renal artery shows increased resistance, often with a reversed diastolic flow.
54Renal artery stenosisusually occurs during the first 3 years after surgery and is the most common vascular complication after renal transplantation, occurring in ≤10% of patients
55Approximately half of stenoses occur at the anastomosis Patients often present with severe hypertension, audible bruit over the graft and graft dysfunction.Doppler US will show a focal area of color aliasing with peak systolic velocities >200 cm/sec .A tardus-parvus waveform may be appreciated in the arcuate and interlobar arteries of the renal parenchyma
60Renal vein stenosisis less common and usually results from extrinsic compression by fluid collections or perivascular fibrosis.Doppler US shows focal aliasing with a three- to fourfold increase in velocity indicating a significant stenosis
61Normal velocity in the renal vein at the level of hilum At the anastmosis, there is focal color aliasing and elevated velocity
62Arteriovenous fistulas and pseudoaneurysms are possible complications from percutaneous biopsy of the transplant kidneyThe majority of these lesions are small and clinically insignificant. However, large shunts may lead to renal ischemia, and rupture of large arteriovenous fistulas and pseudoaneurysms can cause hematuria or perigraft hemorrhage
63AVM- focal area of mixed colors ( aliazing), with high velocity, and increase diastolic flow, due to AV fistula.
64Pseudoaneurysm- may appear as simple cyst on gray scale imaging but with typical swirling arterial flow on color doppler