Presentation on theme: "Malnutrition Protein / Energy. Definitions of Malnutrition Kwashiorkor: protein deficiency Marasmus: energy deficiency Marasmic/ Kwashiorkor: combination."— Presentation transcript:
Malnutrition Protein / Energy
Definitions of Malnutrition Kwashiorkor: protein deficiency Marasmus: energy deficiency Marasmic/ Kwashiorkor: combination of chronic energy deficiency and chronic or acute protein deficiency Failure to thrive: marasmus in U. S. children under 3.
Definitions of Malnutrition PEM Primary: inadequate food intake Secondary: result of disease FTT In-organic: inadequate food intake Organic: result of disease
History Marasmus well known for centuries Kwashiorkor: Cicely Williams – Ga tribe in Ghana “the sickness the older child gets when the next baby is born” – Starch edema, sugar babies Similar but different diseases
How many? 36% of children in the world are underweight 43% stunted 9% wasted Better nutrition, but more children in high risk areas, yields more children affected.
Causes Social and Economic – Poverty – Ignorance – Inadequate weaning practices – Child abuse – Cultural and social practices Vegan Low fat diets
Age of child Infants and young children – High nutritional needs – Early weaning or late weaning – Poor hygiene Marasmus < 1 year Kwashiorkor >18 months with starchy weaning foods
Pathophysiology Develops slowly, adapts to decreased intake – Marasmus – Less fragile metabolic equilibrium Less effective adaption or acute problem – Kwashiorkor, mixed
Energy Decreased intake yields decreased activity – Decreased play and physical activity Mobilization of body fat, weight loss, – Subcutaneous fat – Muscle wasting Maintains visceral protein in marasmus – Nl albumin Larger protein deficit leads to faster visceral protein falls and edema.
Biologic differences Marasmus – Weight loss – Nl or low protein – Boarderline hgb, hct – NL AA profile – Nl blood glucose – Nl enzymes – Nl transaminase Kwashiorkor – NO weight loss – High extracellular water – Low hgb, hct – Low protein – Elevated AA profile – Low enzymes – High transaminase
Pathophysiology Cardiac – Output, heart rate and blood pressure decrease – Postural hypotension Immune system – T lymphocytes and complement decreased – Susceptible to bacterial infection Cytokines (glycoproteins) – Poor immune response – TNF inc leading to anorexia, muscle wasting and lipid changes
Pathophysiology Decreased total body potassium – Not electrolytes, but problem in rehabilitation GI function – Poor absorption of lipids, and sugars – Decreased enzyme and bile production – Increase incidence of diarrhea, and bacterial overgrowth
Pathophysiology CNS – Decreased brain growth and myelnation – Electrical changes similar to dylexia Parental adaptation – Increased breastfeeding – Altered expectations
Diagnosis Anthropometry – Acute: Wasting: low weight for height – Chronic: Stunted: low height for age 4 groups – Normal – Wasted not stunted: acute PEM – Wasted and stunted: acute and chronic PEM – Stunted not wasted: past PEM, nutritional dwarfs
Diagnosis Normal: ± 1 SD Mild: -1.1 to -2 SD Moderate -2.1 to -3 SD Severe greater than -3 Less than 5 th percentile in US BMI in adolescents – Moderate <15 ages 11-13, <16.5 ages – Severe <13 ages 11-13, <14.5 ages 14-17
Diagnosis Mild to moderate – Weight loss if acute, decreased growth velocity of chronic – Decreased activity Marasmus – Skin and bones, thin hair, monkey face – Hypoglycemia, hypothermia
Diagnosis Kwashiorkor – Soft pitting edema, starting in feet and legs – Skin lesions – Skin dry, with hyperkeratosis and hyperpigmentation – Preserved fat layer, small weight deficit, ht may be normal – Dry brittle hair – Anorexia, with vomiting and diarrhea
Diagnosis Mixed – Edema, with or without skin lesions – Muscle wasting and loss of subcutaneous fat
Treatment Acute/ life threatening – Fluid and electrolyte K and Mg shifts Oral rehydration, slowly ml/kg – Infections: main cause of death Aggressive treatment, but disease alters metabolism of drugs – Other deficiencies Anemia and heart failure, care with transfusions and no diurretics Vitamin A: immediate treatment
Treatment Slow re-feeding – Small frequent feeding around the clock – Patient encouragement of food Nutritional rehabilitation – Play and teaching – controlinfections
Recovery? At home Reach weight for height and replete muscle mass – Normal is 25-75% weight for height and continue for one months after Treat other deficiencies Family problems Who does this include here? – Tube feeding. – Disabilities – FTT
What does it mean? Poverty – Correlation of income, wt, ht and hgb in US – What is wealth? – Importance of food choice Brain development – Iron deficiency: neuro transmitters – Brain waves:
What does it mean? Learning: – Difference in treatment by parents Duration of breastfeeding Expectations – Long term effects INCAP two villages, one protein and one calorie At 18 protein supplemented group had higher performance scores irrespective of educational exposure. They had taught themselves.
What does it mean? Learning: – Difference in treatment by parents Duration of breastfeeding Expectations – Slums of Kingston, Jamaica Educational intervention, early rise plateau Nutritional intervention, late rise Additive effect Education lasts, not nutrition, but high IQ mom’s and nutrition group did as well as education.
Implications Children learn by interacting with the environment – Poverty: limited environment – Malnutrition: limited interaction – Additive effect! Loss to society of human potential – Lead graph