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Colibacillosis F5+ group of E.coli Pili serogroups K99, K88, F41, 987P, F18. ST and LT enterotoxins Inadequate colostrum Sow agalactia Viruses, coccidia.

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Presentation on theme: "Colibacillosis F5+ group of E.coli Pili serogroups K99, K88, F41, 987P, F18. ST and LT enterotoxins Inadequate colostrum Sow agalactia Viruses, coccidia."— Presentation transcript:

1 Colibacillosis F5+ group of E.coli Pili serogroups K99, K88, F41, 987P, F18. ST and LT enterotoxins Inadequate colostrum Sow agalactia Viruses, coccidia

2 Clinical signs colibacillosis  Nursing attempts by littermates  Diarrhea- non odorous, non bloody  Shivering, cold  Piling up  Dehydration  Differentiate:  Septicemia  Clostridium perfringens type C  Coccidiosis  Edema disease

3 Treatment of colibacillosis zIntraperitoneal glucose, fluids zOral gentamicin, neomycin zProvide supplemental food yFeeding neonates y10 to 30% of body weight yGavage yMix whole milk with evaporated milk or cream ySupplemental solid starter with plasma yPROVIDE WATER

4 Alkaline stool pH (>7.4)

5 Prevention of colibacillosis zCount teats/piglets-cross foster zCull sows with MMA, check sow diets zDietary changes zVaccinate yCommercial vaccines yAutogenous bacterins yAutocthonous vaccination zWarmth, hygeine zDelay iron injections

6 Swine edema disease zSudden death or CNS signs in weaned piglets zFastest growing pigs zSporadic, and then endemic; 5 to 45% morbidity zEtiology - enteric toxemic E. coli zBacterium survives in moist crevices, water nipples zHigh soy protein diet

7 Swine edema disease zE. coli F18+ secretes verotoxin VT2e zAttaches to enterocyte receptors zEnterocyte receptors unexpressed in sucklers zToxin absorbed produces edema z5 to 45% case attack rate zBacteria survive disinfection

8 Edema disease Signs  Peracute form  Found Dead  Swelling around eyes  Acute form  Squealing  Circling or pivoting  Convulsions  Normothermic  Facial and subcutaneous edema  Diarrhea

9 Management of Edema Disease y100% mortality- Treatment in ineffective ySusceptibility of E. coli needed yFood additive- Tetracycline, Spectinomycin, Mecadox yIncrease food fiber, decrease soy protein y20% oats in feed yAutogenous bacterin yWater based modified live vaccine yPurchase F18+ resistant pigs yFumigate, or disinfect with Quaternary ammonium, Clorox in waterers

10 Transmissible Gastroenteritis(TGE) zAcute epizootic disease of swine. zSows - acute fever, vomition, anorexia and agalactia, recovery in 4 to 5 days zPiglets - Severe intractable diarrhea, dehydration. zAcidic stool pH z~100% death losses in piglets; 0% losses in sows

11 TGE Facts zEtiology = Corona virus z1 gene different from the respiratory corona virus of swine zLabile at 72 C, stable at freezing zWell managed herds zClinical course = 2 to 3 days zSows shed virus in milk for up to 2 weeks zInfection becomes sporadic after initial outbreak

12 More on TGE zVillus denuded, and lactose unabsorbed zOsmotic diarrhea, shortened intestinal villi zImmunity due to lactogenic IgA zVaccines stimulate IgG zBirds, mice, rats, dogs, cats, veterinarians feed trucks can transmit zEliminate with test and eradicate, all in all out, MEW or SPF pig facility.

13 TGE Lesions Normal TGE

14 Coccidiosis zPatency early in swine (1 to 3 weeks) zIsospora suis z4 to 5 day life cycle in pigs. Oocysts infective by 12 hours in summer z20% mortality, sporadic infections zCheck all diarrheas with a fecal flotation zAmprolium treatment zFarrowing crate sanitation critical

15 Students: zHow would you differentiate: zColibacillosis from coccidiosis? zColibacillosis from edema disease? zEdema disease from coccidiosis? zEdema disease from Clostridium perfringens type C?

16 Clostridium perfringens type C Sharp demarcation zAcute diarrhea and death< 1week of age 5 to 20% morbidity zInfection from dam shortly after birth zJejunal proliferation zIntestinal necrosis zFibrinous bloody diarrhea zPeracute death (100%) zPeritonitis zMass medicate with lincomicin or tiamulin zVaccinate sows; antiserum to piglets good bad ugly

17 Ascaris suum (roundworm) zThick shelled egg long lived in soil zDevelopment and 1 molt L2 in egg zIngested (native or worm) molts in small intestine zBurrows goes to liver and molts L3 zMigrates to lungs (4 to 6 dy), coughed zSwallowed, molts 2 x to adults

18 Sowschwitz Normal pig Milk spots Hepatic fibrosis Lung lesions Adult Ascarids

19 Clinical signs ascarids zUnthrifty zCough zThumps zAscites zClay colored stool zWorms in stool or vomitus zColic, obstipation, Jaundice

20 Diagnosis and treatment of ascariasis zFecal egg count (>500 epg) zNecropsy  Treat L2 ’ s with pyrantel  L3 ’ s in liver with fenbendazole  L3 ’ s in lung with FBZ or thiabendazole  L4 ’ s in intestine with ivomec, pyrantel, fenbendazole, dichlorvos zAdults with any of the above plus piperazine

21 Prevention ascarids zWorm and shampoo sows prior to farrowing zWean piglets at 3 weeks of age zBanminth zClean pens and pastures Q3 weeks zRotate pastures Q 3 weeks

22 Trichuris suis zExtremely common zPastured pigs z21 day scours (Post pasturing), non patent infections, cramping, bloody scours zMostly asymptomatic zDirect life cycle zAtgard, fenbendazole zRaise pigs on concrete

23 Swine salmonellosis zCommon among feeder pigs zMixed source groups are particularly at risk z3 types: yS. typhimurium type B -bloody scours, rectal strictures yS. choleraesuis type C1-bloody scours secondary to Hog Cholera yS. typhisuis type C2 -swine adapted granulomatous colitis and pneumonia

24 Clinical signs of swine salmonellosis zFever, purplish lividity zBloody scours zAcute death zRectal stricture zPyogranulomatous colitis

25 Treatment/management salmonellosis zTreat with Ceftiofur or Nuflor zSegregate or euthanize affected pigs zAll in-All out, MEW, SPF, disinfect premises with bleach zAutogenous bacterin zPot bellied pigs may be treated with amikacin, timentin.

26 Lawsonia intracellularis zCommon small intestinal disease (96% herds positive) zSwine, horses, late feeder period zSyn = Proliferative enteropathy, necrotic enteritis, regional ileitis, proliferative ileitis, proliferative enteritis zGram negative, obligate intracellular desulfovibrio family

27 Lawsonia infection zInfection at 2-3 wks, prolonged shed, growers adults affected, stress related zClinical forms  “ Johne ’ s like ” form of chronic wasting, hypoalbuminemia, and loose stool yAcute fevers scours, with or without hematochezia. Mortality >10%. yFever, anorexia and dark stool in adult swine zPathologic lesion = thickened intestine; PCR test diagnostic zTreat with food tylosin or lincomycin

28 “Hosepipe gut”

29 Swine dysentery zHighly contagious zFeeders 6 to 8 weeks of age and adults zPrevalent in California zLarge bowel infection by Serpulina (Brachyspira) hyodysenteriae zIntestinal anaerobes enhance disease

30 Swine dysentery zSerpulina survives in manure 6 to 8 wks @ 98F zIn dogs for months, birds, mice, and humans zIn pigs for years zClinical signs yAcute, fever, bloody scours yFibrinous casts ySepsis, purplish discoloration of the ears yExsanguination (15 to 50% mortality)

31 Diagnosis swine dysentery zCecal scrapings darkfield - spiral shaped bacteria zVictoria Blue R stains of intestinal sections zDifferentiate from Serpulina pilosocoli and S. innocens z6 Strains of S. hyos. zHemolysin and enterotoxin Pathologic lesions restricted to colon

32 Treatment of Swine Dysentery zTiamulin zMecadox zLincomycin zVirginiamycin zNOT dimetridazole zInjection of lincocin for sick pigs zDrug delayed-enhanced forms of disease

33 Control of swine dysentery zRodent, dog, bird, cat, human control essential zBlitz treat (metaphylaxis) herd 30 days zShampoo pigs and disinfect with 0.5% Clorox zMove to new pen zFumigate or quaternary ammonium disinfectants

34 Gastric ulcers Pallor Stool zFeeder pigs and boars zCause unknown  “ Coffee grounds ” vomitus  Scant “ road ashpalt ” stool zPallor, and depression zCharacteristic blood loss hemogram

35 zPeach pits zSkewers zSofa cushion zTar paper zChristmas wrapping zDead babies Intestinal Obstructions

36 Signs of obstructions zColic zLethargy zObstipation zVomition zAnorexia zTachycardia

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