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RECRUITMENT TALK Remember There are few positions and many candidates 200-500 candidates for any tenure track faculty position 10 qualified people for.

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Presentation on theme: "RECRUITMENT TALK Remember There are few positions and many candidates 200-500 candidates for any tenure track faculty position 10 qualified people for."— Presentation transcript:

1 RECRUITMENT TALK Remember There are few positions and many candidates 200-500 candidates for any tenure track faculty position 10 qualified people for each position I receive 30-50 unsolicited requests per month Step 1: Getting the Interview CV and personal statement Review standard University CV formats I do not care what you think your skills are I want to know what you have produced I want to know what your training is I will respond better to what I am used to seeing

2 What am I looking for in a trainee candidate What am I looking for in a faculty candidate RECRUITMENT TALK

3 You only get one chance to make a first impression –Arrive early –Dress Professionally Males Tie and Jacket Females Consider a suit –At least a dress or skirt. Live with your clothes. Do not fidget I am looking for a professional colleague –Slides must be clear, single format RECRUITMENT TALK

4 What am I looking for in a trainee candidate –Career goals What do you want to do in 5 years How will you get there: What are your strengths and weaknesses Are you driven to succeed –Talk Organization Thought process Much more important than the data Handling questions more important than the talk –NEVER EVER INTERRUPT –I am making a commitment to your career Will you be successful Are you teachable Do you want to learn or do you already know it all RECRUITMENT TALK

5 What am I looking for in a Faculty Candidate –Someone I trust Represent me in meetings Not cause problems in and for the department A team player and collaborator: Team sports There is no “I” in a talk –Someone I want to work with, go to dinner with, go to meetings with –Someone who will make me better or my life easier Will they teach classes well –Will they get grants –Are they going to be a good teacher –Are they intellectually curious; Will they listen to my questions. Will they review my grant and help me –Have they asked their supervisor about the project and what they can take with them RECRUITMENT TALK

6 –There are many candidates. –Recruitment is occasional. –For students, we are looking at being together for 4-6 years, PDFs 3-4 years, faculty a lifetime. –Divorce (termination) is painful –Estimated cost of a “wrong” faculty rectruitment: 750K –There are many ways to make a mistake, few to make a good first impression –Better to recruit no one than the wrong one RECRUITMENT TALK

7 3 PARTS Scientific Presentation One on one interviews Dinner

8 RECRUITMENT TALK PREPARATION FOR THE TRIP Its not all about the talk DO YOUR HOMEWORK. Institution If you are going to Duke, know about the basketball team If you are going to UT, know about the football team Texas A and M, know what an Aggie is. People Study your agenda Know who you are meeting. Review online. What is their latest paper. Know their history Many people have websites or lab websites IL2, LAKs and TILs Know who you are going to dinner with

9 RECRUITMENT TALK TALK Prepare practice and give it to as many people whowill listen Have people look at slides Spelling errors, too busy Use SpellCheck PDF presentation is safest approach Do not tell jokes or try to be funny. You can have an amusing slide NO motion slides unless absolutely necessary If possible overlay slides if motion needed

10 RECRUITMENT TALK THE TALK Expect to be nervous Where to stand Your slides can be crutches. Do not read your slides but they are there if you need them Speak slowly and clearly If you get lost, do not panic. Take a deep breath and start again. Make clear transitions. A few second gap is OK. Tell one or maybe two stories well, not many. Do not assume anyone has read your favorite papers including your own.

11 THE TALK Every slide should have a message and a reason to be in the talk Tell a story. The talk should have a beginning middle and end. –Place the topic in context Big picture –Logic flow: A set of slides showing what you will present: Fade in an out. –Results –Conclusion –Appropriate amount of time 45 minutes RECRUITMENT TALK

12 THE TALK –Are you logical –Are you careful –Acknowledge anyone who did the work on the slide –Introduction Put the topic in context –Enough background so people understand the question –What is the question –Why is this important RECRUITMENT TALK

13 The four slide cassette Introduction slide Set the question Present a model describing the question A picture is worth a thousand words! Method slide What was done and why Explain the approach and why Data slide Make a new slide for the talk with key points only NOT from your paper Controls are critical Are you careful. Conclusion/transition slide What does the data show you Go back to your model Present a revised model slide What is the next question Set the next cassette RECRUITMENT TALK

14 THE END What have you learned What are the next questions One and maybe two slides –What would the title of your grant application be –What is the model –What are the aims RECRUITMENT TALK

15 THE DREADED DINNER –Do not drink AT ALL It is too easy to sip too many times. If they order you a drink or a glass of wine pick it up put it to your lips occasionally and do not drink –Think about what you order Order a salad Main course should be easy to eat Skip desert Only order coffee after others DO NOT order spaghetti. –Do not discuss politics or religion unless asked and then say little and try to change the topic –Nobody cares about how they do things at home –You must participate –People like to talk about themselves Where are they from. How did they get to the institution. Why did they come –Try to sit next to someone you know or the recruit leader –The Dinner is not a time to ask contentious questions RECRUITMENT TALK

16 THE OFFER Review carefully Ask questions but not too many –No one wants to work with someone who is a pain Your best chance to negotiate is up front –No one wants to work with someone who is not excited about the job. Too much negotiation will lose the job Produce and renegotiate Produce and move elsewhere

17 Gordon B. Mills Department of Systems Biology WHAT GOES AROUND COMES AROUND: MULTIPLE GENOMIC AMPLICONS TARGET VESICLE RECYCLING AND BIOENERGETICS Joe Gray William Muller Jim Norman

18 JOE GRAY LBL AND FRIEND FISHING CAN WORK IF YOU USE THE RIGHT BAIT 15 years of fishing in the genome pool

19 * * * * * ** ** * Melissa Bondy, Patricia Thompson, Spyros Tsavichidis Early Stage Breast Cancer Resource (2408 tumors Stage 1,2 paraffin n= 971 MIP arrays) Decision tree analysis

20 GENOMIC ABERRATIONS TARGET ENDOCYTOSIS AND POLARITY PKCi PIK3CA MDS1 EVI1 Mir PVT1 Myc Rab11FIP1 RCP Rab25 ZNF217 Cyclin D1 ERBB2 Grb7

21 RAB11FIPS AND RAB11 FAMILY MEMBERS ARE OVEREXPRESSED IN CANCER Bittner Oncomine

22 RAB25 AND RCP COOPERATE IN LUMINAL B TUMORS Rab25 is expressed in ER positive and HER2 positive, low in basal, absent in Claudin low Ju-Seog Lee Fan Zhang

23 RAB25 AND RCP COOPERATE IN LUMINAL B TUMORS Ju-Seog Lee Fan Zhang

24 DEGRADATION RECYCLING DECISION Specific Signaling Complexes RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE PLEIOMORPHIC FUNCTIONS Polarity Proliferation Migration Invasiveness Apoptosis Cargoes Integrins Gluts EGFR family Transferrin Polarity Proliferation Migration Invasiveness Apoptosis Cargoes Integrins Gluts EGFR family Transferrin Jim Norman

25 RAB25 AND RCP REGULATE MOTILITY AND INVASION THROUGH SPATIALLY RESTRICTED RECYCLING AND LOCALIZED SIGNALING Jim Norman

26 Rab25 drives extension of invasive pseudopods Patrick Caswell/Heather Spence N Rab25/  5  1 compartment is located near the tip GFP-  5 integrin Cherry-Rab25

27 RAB25 INTERACTS WITH EGFR Roshan Agarwal Kwai Wa Cheng

28 RAB11 GDP RAB25 GTP RAB25 includes a sequence change found in mutant RAS and should be GTP bound Dominant active Rab11 family member Rab25 preferentially binds RCP and integrins in presence of Rab11 DEGRADATION RECYCLING DECISION Specific Signaling Complexes RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE PLEIOMORPHIC FUNCTIONS Polarity Proliferation Migration Invasiveness Apoptosis Cargoes Integrins Gluts EGFR family Transferrin Polarity Proliferation Migration Invasiveness Apoptosis Cargoes Integrins Gluts EGFR family Transferrin

29 RAS Raf Mek MAPK AKT GSK 3 DEGRADATION RECYCLING DECISION Specific Signaling Complexes TGF  signaling TGF  signaling RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE PLEIOMORPHIC FUNCTIONS Polarity Proliferation Migration Invasiveness Apoptosis Cargoes Integrins Gluts EGFR family Transferrin Polarity Proliferation Migration Invasiveness Apoptosis Cargoes Integrins Gluts EGFR family Transferrin

30 Rab25 RCP RAB25 AND RCP EXIST AS A HETEROTETRAMERIC COMPLEX Greg Verdine Stapled peptides

31 RAB25 INTERACTION NET: ReMTH, Yeast two hybrid, ip Mass Spec, Lumiere, Literature, STRING Igor Jurisica, Roshan Agarwal, Zhiyong Ding, Kwai Wa Cheng, Jim Norman GLUT1 Integrin  5  1 EGFR TGF  R1 AKT RCP Actin capping protein

32 RAB25 TRANSCRIPTOME IMPLICATES RAB25 IN BIOENERGETICS 53-gene signature Roshan Agarwal Kwai Wa Cheng

33 GLYCOGEN IS A POTENTIAL ENERGY SOURCE GSK3 AKT GPI Rab 25

34 ATP and GLYCOGEN ARE INCREASED BY RAB25 Kwai Wa Cheng

35 GLYCOGEN STORES CONTRIBUTE TO THE ABILITY OF RAB25 TO MAINTAIN ATP LEVELS Roshan Agarwal Kwai Wa Cheng Rab 25

36 Mechanisms of action of Rab25

37 COLLABORATORS MILLS LABJoe GrayLBL Rab25 Kwai Wa ChengBill MullerMcGill Canada Roshan Agarwal Sofie ClaerhoutJim Norman Beatson Scotland Yiling Lu Qinghua YuIgor JurisicaUniversity of Toronto Shuangxing Yu Shreya Mitra ReMTH Zhiyong DingRobert BastMD Anderson BioenergeticsJu Seog LeeMD Anderson Jae Ho Cheong Jiyong Liang RPPA/PI3K/Patient samples outcomes Yiling Lu Bryan Hennessy Ana Gonzalez Mark Carey Fan Zhang

38 COLLABORATORS MDACCSan FranciscoJoe Gray Wenlin Kuo Ju-Seog Lee Prahlad Ram BostonJoan BruggeLevi Garraway Gabor Balazsi John AlbeckYoko Irie Shiaw-Yih “Phoebus” Lin St. Louis Chuck Perou Georg Halder VanderbiltCarlos Arteaga Gabriel Hortobagyi UBC Sam AparicioDavid Huntsman Funda Meric-Bernstam Baylor Zhou “Sunny” Songyang Robert Bast Cheryl Walker Powel Brown Adrian Lee Jenny Chang Steve Kornblau Holland Rene Bernards Melissa Bondy John Heymach Norway Anne-Lise Boerresen-Dale Michael Andreeff Therese Sorlie Eric JonaschSpain Jose BaselgaAna Lluch Tissue Bank Ayesegul SahinToronto Patricia Shaw Heather Begley Karen Lu Ignacio WistubaSan Francisco Karen Smith McCune Rosemarie Schmandt Bioinformatics Toronto Igor Jurisica Kevin CoombesJohn WeinsteinSan Francisco Paul Spellman, William Gibb Jonas AlmeidaKeith Baggerly Sach Murkherjee Mandri ObeyesekereGSK/Semafore/Abbott/Exelixis/Keryx

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