Presentation on theme: "Experimentally induced gastric ulcer in the rat MUDr. Michal Jurajda."— Presentation transcript:
Experimentally induced gastric ulcer in the rat MUDr. Michal Jurajda
Objective n To study the influence of H2-receptor antagonist on the development of the peptic ulcers of the stomach in the rats.The peptic ulcers will be induced experimentally by NSAID (cyclo- oxygenase inhibitor).
Physiology n Motor functions of the stomach n Gastric secretion
Physiology n Motor functions of the stomach –storage: reduction of the tone in the muscular wall –mixing and propulsion: constrictor ring leading to the retropulsion –emptying
Pathology n Gastritis –Acute - stress (Cushing’s ulcer), infection, radiation, corrosives –Chronic A type – autoimmune destruction of the parietal cells, B type – inflammation of the antral mucosa caused by H. pylori
Ulcerogenic factors n NSAID n Stress n Chronic gastritis type B n A habitual increase of oxyntic glands secretion (increased number, increased sensitivity to k histamine or gastrin. n Zollinger-Ellison syndrom