1. HOW CAN NEUROIMAGING HELP UNDERSTAND, DIAGNOSE, AND DEVELOP TREATMENTS FOR ALZHEIMER'S DISEASE? Part D2 – AD brain scans – metabolism - PET NUCLEAR MEDICINE GRAND ROUNDS Stanford University J. Wesson Ashford, M.D., Ph.D. Clinical Professor (affiliated), Department of Psychiatry and Behavioral Sciences Senior Research Scientist, Stanford / VA Aging Clinical Research Stanford University and VA Palo Alto Health Care System January 5, 2010 Slides at: www.medafile.com (Dr. Ashford’s lectures)www.medafile.com

2. Minoshima et al., 1997

3. Courtesy of S. Minoshima, University of Washington FDG-PET in AD and MCI

4. Regions of the Brain with Reduced Rates of Glucose Metabolism in 11 e4 Homozygotes and Their Relation to Brain Regions with Reduced Glucose Metabolism in 37 Patients with Probable Alzheimer's Disease. Reiman et al., 1996 The purple areas are regions in which glucose metabolism was significantly reduced only in the group with probable Alzheimer's disease, the blue areas regions in which glucose metabolism was significantly reduced in both the 4 homozygotes and the patients with probable Alzheimer's disease, and the green areas regions in which glucose metabolism was significantly reduced only in the 4 homozygotes.