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H1 M1 D2 1 conventional antipsychotic drug 11-7 Stahl S M, Essential Psychopharmacology (2000)

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Presentation on theme: "H1 M1 D2 1 conventional antipsychotic drug 11-7 Stahl S M, Essential Psychopharmacology (2000)"— Presentation transcript:

1 H1 M1 D2 1 conventional antipsychotic drug 11-7 Stahl S M, Essential Psychopharmacology (2000)

2 pure D2 blocker 11-2 Stahl S M, Essential Psychopharmacology (2000)

3 Increase in negative symptoms 11-3 Stahl S M, Essential Psychopharmacology (2000) Mesocortical pathway

4 EPSs 11-4 Stahl S M, Essential Psychopharmacology (2000) Nigrostriatal pathway

5 Blockade of receptors in the nigrostriatal dopamine pathway causes them to up- regulate This up-regulation may lead to tardive dyskinesia 11-5 Stahl S M, Essential Psychopharmacology (2000)

6 Motor and mental features of neuroleptic- induced extrapyramidal side effects ParkinsonismTremor (resting), rigidity, bradykinesia, masklike facies AkathisiaRestlessness, pacing, fidgeting, shifting from jitteriness, anxiety, irritability, anger, difficulty concentrating DystoniaMuscle contractions, tongue protrusion, torticollis, opisthotonos, fear, distress, paranoia Tardive Buccolingual-masticatory movements of irregular dyskinesia (nonrhythmic) nature; choreiform or athetoid (writhing) movements of fingers, extremities, trunk Adapted from Ayd 1995; Casey 1995

7 D2 receptor prolactin D2 antagonist 11-32 Stahl S M, Essential Psychopharmacology (2000) pituitary lactotroph

8 Typical antipsychotic drugs: potencies and side effect profiles Drug Approximate Sedative Hypotensive Anticholinergic Extrapyramidal dose (mg) effect effect effect effect Phenothiazines Chlorpromazine (Thorazine) 100 H H M L Piperidines Thioridazine (Mellaril) 95 H H H L Piperazines Fluphenazine (Prolixin) 2 M L L H Perphenazine (Trilafon) 8 L L L H Trifluoperazine (Stelazine) 5 M L L H Thioxanthene Thiothixene (Navane) 5 L L L H Butyrophenones Haloperidol (Haldol) 2 L L L H

9 5HT2A D2 SDA 11-16 Stahl S M, Essential Psychopharmacology (2000)

10 5HT-DA Interactions 11-17 Stahl S M, Essential Psychopharmacology (2000) Substantia nigra raphe nucleus brake

11 serotonin neuron dopamine neuron Substantia nigra Raphe dopamine 5HT2A receptor serotonin 5HT2A receptor 11-18 Stahl S M, Essential Psychopharmacology (2000)

12 mesocortical pathway primary dopamine deficiency secondary dopamine deficiency dopamine release serotonin SDA 11-27 Stahl S M, Essential Psychopharmacology (2000)

13 5HT2A receptor Nigrostriatal pathway 11-24 Stahl S M, Essential Psychopharmacology (2000)

14 5HT7 5HT65HT3 5HT2C 5HT1A M1 H1 1 2 D1 D3 D4 5HT2A D2 clozapine 11-37 Stahl S M, Essential Psychopharmacology (2000)

15 5HT7 1 2 5HT2A D2 risperidone 11-39 Stahl S M, Essential Psychopharmacology (2000)

16 5HT65HT3 5HT2C M1 H1 1 D1 D3 D4 5HT2A D2 olanzapine 11-40 Stahl S M, Essential Psychopharmacology (2000)

17 5HT7 5HT6 H1 1 2 5HT2A D2 quetiapine 11-41 Stahl S M, Essential Psychopharmacology (2000)

18 5HT1D SRI NRI 5HT7 5HT2C 5HT1A 1 D3 5HT2A D2 ziprasidone 11-43 Stahl S M, Essential Psychopharmacology (2000)

19 Side effects of selected atypical agents

20 POSITIVE SYMPTOM PHARMACY 3rd line treatment 2nd line treatment noncompliant (depot) 1st line treatment in case of emergency polypharmacycombos D2 clozapine D2 SDA D2 BZ 11-52 Stahl S M, Essential Psychopharmacology (2000)

21 Hierarchy of Treatment Goals in Medical Psychotherapy of Schizophrenia Acute Phase –Medical/neuropsychiatric assessment –Rapid symptom reduction –Reduce impact of episode on friends, family, housing, activities Convalescent Phase –Gain trust/alliance with family/caregivers –Assess and mobilize social supports –Ensure human service needs are met (food, clothing, housing) –Ensure safety and predictability of environment Adaptive Plateau –Establish therapeutic alliance/supportive treatment routine –Achieve effective maintenance medication regime Stable plateau –Psychoeducation: Promote illness self-management strategies, awareness of relationship between stress and symptoms –Rehabilitation: Teach adaptive competencies


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