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CycLex Co., Ltd. All Rights Reserved. Antagonism of ubiquitination Differential protein-protein interaction Nuclear pore complex shuttling Subcellular.

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Presentation on theme: "CycLex Co., Ltd. All Rights Reserved. Antagonism of ubiquitination Differential protein-protein interaction Nuclear pore complex shuttling Subcellular."— Presentation transcript:

1 CycLex Co., Ltd. All Rights Reserved. Antagonism of ubiquitination Differential protein-protein interaction Nuclear pore complex shuttling Subcellular localization Integrity of PML nuclear bodies Regulation of DNA binding Transcription factor activity Higher-order chromatin structure Sumo Substrate Signaling functions of SUMO

2 CycLex Co., Ltd. All Rights Reserved. Sumo GGHSTV Sumo CO SAE2 SAE1 O SH Sumo SAE2 SAE1 S O C UBC9 SC Sumo UBC9 SH Substrate φKXE NH 2 Substrate φKXE HNC O Sumo C-terminal hydrolase ATP Ligase E3 Sumo conjugating pathway Activating enzyme E1 Conjugating enzyme E2 O

3 CycLex Co., Ltd. All Rights Reserved.

4 MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGGHST V MSDQDSSEIH FKVKMTTHLK KLKESYCQRQ GVPMNSLRFL FEGQRIADNH TPKELGMEEE DVIEVYQEQT GGHSTV Sumo 1 MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLSMRQIRF RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGVY Sumo 2 MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QLEMEDEDTI DVFQQQTGGV Y MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ GLSMRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGVPESSLAG HSF Sumo 3

5 CycLex Co., Ltd. All Rights Reserved. RanGAP1 HMGLLKSEDKV PML (1) PML (2) HQWFLKHEARP PRKVIKMESEE Sp100 RLVDIKKEKPF p53 KKLMFKTEGPD IκBα PRDGLKKERLL c-Jun RLQALKEEPQT IE2 (1) IE2 (2) MLPLIKQEDIK KQEDIKPEPDF HSF2 DSGIVKQERDG AR PHARIKLENPL CONSENSUS (φ)KXE(φ)KXE SubstrateTarget Site Sumoylation Target Site

6 CycLex Co., Ltd. All Rights Reserved. PIAS1 PIAS2 PIAS3 PIASxα/ARIP3 STAT1 STAT3 Androgen Receptor PIASxβ/Miz1Msx2GBP mouseDisable (mDab) DJ-1 p53 HMGI-CGfi-1 Sumo Ligase E3 PIASyLEF1 p73α c-Myb PLAG1 RanBP2RanGAP1HDAC4 Sumoylation Target Protein


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