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Chapter 15 Enzyme Specificity and Regulation. 15.1 Specificity Is the Result of Molecular Recognition 15.1.1 Enzyme Specificity Structural specificity.

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Presentation on theme: "Chapter 15 Enzyme Specificity and Regulation. 15.1 Specificity Is the Result of Molecular Recognition 15.1.1 Enzyme Specificity Structural specificity."— Presentation transcript:

1 Chapter 15 Enzyme Specificity and Regulation

2 15.1 Specificity Is the Result of Molecular Recognition Enzyme Specificity Structural specificity Stereospecificity

3 Hypothesis of Enzyme Action the “lock and key” hypothesis the “induced fit” hypothesis

4 Active Site of Enzyme The specific site on the enzyme where substrate binds and catalysis occurs is called the active site.

5 15.2 Allosteric Regulation Feedback inhibition (or regulation) A B C D Z E1 E2 E3 En A B C D Y E Z E1 E2 E3 E4En E3* E4*En*

6 Sigmoidal curve

7 Allosteric activator Allosteric inhibitor CO 2 + Glu + ATP CTP N-carbamoylaspartate Asp ATCase Carbamoyl phosphate Activation Inhibition

8 15.3 Reversible covalent modification

9 15.4 Proteolytic Activation

10 Pancreatic Proteases Trypsinogen Enteropeptidase Trypsin Chymotrypsinogen Proelastase Chymotrypsin Elastase

11

12 Blood Clotting Cascade

13 15.5 Regulation of Enzyme Synthesis and breakdown 15.6 Isozyme


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