Presentation on theme: "Serum Lipid Profile, Apolipoprotein E Genotype and Visceral Leishmaniasis Infection in a Northeastern Brazilian Population Adam P. Simons 1, Gloria R."— Presentation transcript:
Serum Lipid Profile, Apolipoprotein E Genotype and Visceral Leishmaniasis Infection in a Northeastern Brazilian Population Adam P. Simons 1, Gloria R. Monteiro 2, Nubia N. Pontes 2, Taysa M. Feitosa 2, Upasna Gaur 3, Richard D. Pearson 4, Mary E. Wilson 3, Selma M. Jeronimo 2 1.University of California-Davis, Sacramento, CA, 2.Federal University of Rio Grande do Norte, Natal, Brazil, 3.University of Iowa, Iowa City, IA, 4.University of Virginia, Charlottesville, VA
Selective Pressure of ApoE Allele%Genotype% E28.32/21.4 E377.12/311.1 E414.63/358.3 2/42.8 3/426.4 4/40 n=72 children in Ceara Oriá et al (2005) Wiki commons
Future Directions Large-power study of ApoE genotype Lipid metabolic pathways in VL recovery –LXR, PPAR, Cholesterol Biosynthesis pathway gene expression across disease process.
Acknowledgments Mary E. Wilson, University of Iowa Richard D. Pearson, University of Virginia Noah Craft, University of California Edgar Carvalho, UFBA Cristina Otonis, UFRN Gloria Monteiro, UFRN Upasna Gaur, University of Iowa Selma Jerónimo, UFRN NIH, CNPq and UC Davis for financial support