3 Concepts in Genetics 16Pigment in mouse fur is only produced when the C allele is present. Individuals of the cc genotype are white. If c olor is present it may be determined by the A,a allelesAA, results in agouti color, while aa results n black fur.
4 16(a)What F1 and F2 genotypic and phenotypic ratios are obtained from a cross between AACC and aacc miceF1 = AaCc = agoutiF2 = 9 agouti,4 white, 3 black
5 16(b) 1. How do you get 8 Agouti and 8 white AACc x AAcc How do you get 9 agouti, 10 blackaaCC x AaCCHow do you get 4 agouti, 5 black, and 10 whiteAaCc x aacc
6 Problem 23.Five human matings( 1-5) including both maternal and paternal phenotypes for ABO and MN blood group anitgen status, are shown in the following table:
7 Parental Phenotypes ( 1) A, M x A, B (2) B,M x B, M (3) O,N x B, N (4) AB,M x O,N(5) AB, MN x AB,MN
10 Color Vision- Problem 24 RG – normal vision Rg- color blind A husband and wife have normal vision , although both of their fathers are red-green color blind, an inherited X linked recessive condition. What is the probability that their first child will be
12 ExplanationNotice that the mother must be heterozygous for the rg allele( being normal and having inherited an Xrg from her father and the father because he has normal vision, must beXRG
13 Problems - 25In humans, the ABO blood type is under the control of autosomal alleles. Color blindness is a recessive X-linked trait. It two parents who are both type S and have normal vision produce a son who is color blind and is type O, what is the probability that their next child will be female with normal vision?
14 Based on the son who is colorblind and the blood type O XRGXrg, IAIO ,motherXrg/Y , father
15 Solutions - 25 The probability of having a female child is ½ The probabilty that she has normal vision is 1 ( because the father’s X is normal)Probability of type blood is 1/4
16 Problem 10 Fur color C ( full color) cch ( chinchilla) ch ( himalayan )ca ( albino )
17 Problem 10 Multiple alleles and rabbit fur Himalayan x Himalayan Albinochca x chca
18 Problem 10Full color x albinochinchillaCcch x caca cchca
19 Problem 1 – Incomplete dominance In shorthorn cattle, coat color may be red, white, or roan. Roan is an intermediate phenothype expressed as a mixture of re and white hairsRed x white roanRR x WW RW
20 Mixed Problem – Incomplete dominance and dominant and recessive In radishes, flower color may be red, pruple or white. The edible protion of the raidsh may be long or oval. When only flower color is studied not dominance is evident. Red x White yields all Purple. If these F1 purples are interbred, the F2 generation consists of ¼ red:1/2 purple:1/3 white. Regarding radish shape , long is dominant to oval in a Mendelian fashion
22 Problem based on radish facts If a red X unknown produced204 red and 198 purple what is the genotype of the unknown plant?What would the cross of a RWOo plant x RW oo plant produce( just phenotypes)
23 Problem 17In some plants, a red pigment cyanidin is synthesized by a colorless precursor. The addition of a hydroxyl group ( OH) to the molecule causes it to become purple
24 Epistasis Colorless is aa Purple is A_ B_ Red is A_bb In a cross between two purple plants the following results were obtained
25 Results 94 purple 31 red 43 white This is approximately what epistatic ratio?What does this tell you about the genotype of the original purple plants?
27 Problem 26The X linked recessive mutation, scalloped causes irregular wing margins in Drosophila melanogaster, the fruit fly.What occurs if a scalloped female is crossed with a normal male in the F1.
28 F1 Symbol for singed in Fruit flies is sd XsdXsd x X+Y – Parental F1=1/2 XsdX+ This is a female with normal long wings1/2 XsdY – This is a male with scalloped wings that have irregular edges
29 F2 - XsdX+ x XsdY Results in ¼ X+X+ ( normal female) ¼ XsdXsd ( scalloped wing female)¼ X+Y (normal male)¼ XsdY( male scalloped wings)