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Everything You Wanted to Know about Nano-Engineered Materials * (* But Only Had an Hour) Michael Ochs, CIH Jonathan Klane, M.S.Ed., CIH, CHMM, CET ASSE.

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Presentation on theme: "Everything You Wanted to Know about Nano-Engineered Materials * (* But Only Had an Hour) Michael Ochs, CIH Jonathan Klane, M.S.Ed., CIH, CHMM, CET ASSE."— Presentation transcript:

1 Everything You Wanted to Know about Nano-Engineered Materials * (* But Only Had an Hour) Michael Ochs, CIH Jonathan Klane, M.S.Ed., CIH, CHMM, CET ASSE December 2013 Focus Areas and Research CentersNews and Events ObjectivesApplied Nanoionics AINE Kick-Off Worksho p April 4, 2008 Agenda and Presentati ons Agenda and Presentati ons ASU's nanotech program is ranked 6 in the nation- according to Small Times. We are also ranked #1 in commerci alization and #3 in facilities for nanotech nology. The link below will provide more informatio n. View Articles in SmallTim es View Articles in SmallTim es RationaleBiomolecular Integrated Circuits (CBIC) StructureComputational Nanoscience PeoplePhotonics Innovation

2 What’s in a name? Nanotechnology Nanoscale Nano-engineered materials (NEMs) Nanoscience Nanometer! (“Nano Nano!” – Mork)

3 Nanoscale: 1 nm = m A sheet of paper is about 100,000 nanometers thick A strand of human DNA is 2.5 nanometers in diameter There are 25,400,000 nanometers in one inch A human hair is approximately 80, ,000 nanometers wide

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5 Properties of Nanoscale Materials: Nanomaterials have a larger surface area … (When compared to an equal mass of the same material in larger form) More chemically reactive ( toxicity) Strength & electrical properties affected Optical and magnetic behavioral changes

6 Hazard Identification Factors Chemical form Size Shape Surface Area Number Density Mass Agglomeration Porosity Charge Reactivity Solubility Durability Crystalline structure Purity Antigenicity

7 Different Types of Nanomaterials Carbon nanotubes (CNTs) Single Wall (SWNT) Multi Wall (MWNT) Carbon Black Fullerenes, C60 Nanoclays Polymeric Nanoparticles Silver nanoparticles Silicon Dioxide Titanium Dioxide Quantum Dots

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10 Medical app’s: Appetite Control Bone Replacement Cancer Chemical Substitutes Cholesterol Diagnostic Tests Drug Development Hormone Therapy Imaging Immunosuppressant Medical Tools

11 Health and Safety Concerns  Absorption  Ability to penetrate cellular membranes maybe able to past through blood brain barrier  Dermal  Respiratory  Human exposures to airborne nanomaterials must be restricted.

12 More health effects: Mesothelioma in mice (asbestos and erionite) Pulmonary inflammation Possible fibrosis Portal effect = URI

13 Exposures: Need 3 different means of measurements Mass = mg/day Surface area = m 2 /day Number = #/day

14 Potential pathways: Nose … Lower resp. tract … Lymph … Blood … Brain … CSF …

15 Nano Research at ASU: ‘Nanoprospecting’ project: fate/transport and impact of nanomaterials (Paul Westerhoff) Nanoscale energy transport processes (Patrick Phelan) CNTs in ISTB2 Others

16 Nano Research at ASU: AZ Initiative for Nano-Electronics (AINE) Coordinated network nanophotonics, molecular electronics, nanoionics and computational nanoscience ultra-low power/ultra-high speed electronics, and hybrid biomolecular electronics at the interface between the biological and electronics worlds CSSER, LE-CSSS and Bio-Design

17 Nano Research at ASU: ASU’s Center for Nanotech in Society – world’s largest on societal aspects Research (RTTA and TRC) Education (students) Outreach (general public)

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20 Traditional approach to keeping workers healthy… Regulations Toxicological Data Engineering Controls Administrative Controls PPE

21 With nanomaterials, uncertainty creates a dilemma Which PPE? What Regulations? Will Engineering Controls work? What Toxicological Data? Administrative Controls?

22 Can We Manage Exposures? Absolutely What Methods Are Available? The Same Ones We’ve Been Applying

23 Draft guidelines using numerous resources

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25 guide.org/ Nanomat erial+Occ upational +Risk+Ma nagement +Matrix

26 Do you perform exposure sampling? Quantitative sampling have been deemed not necessary for the some risk management programs NIOSH’s strategy relies on area sampling What PEL to reference? Will direct air sampling work? Particle counters are expensive

27 Occupational Exposure Limits NIOSH NIOSH RELs for Nanoscale substances CNT and CNF1 ug/m3 Titanium Dioxide 0.3 mg/3

28 Occupational Exposure Limits OSHA PEL’s of Nanomaterials SUBSTANCE PEL Aluminum oxide 10 mg/m 3 Carbon Black 3.5 mg/m 3 Magnesium oxide 10 mg/m 3 Silver, metal 0.1 mg/m 3 Iron Oxide 5 mg/m 3 Silica, crystalline 0.25 mg/m 3 Chromium, metal 0.5 mg/m 3 Copper, dusts 1 mg/m 3 Titanium dioxide 10 mg/m 3 Tin, metal 2 mg/m 3

29 Occupational Exposure Standards

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31 EH&S Approach Prudent industrial hygiene practice Professional judgment ALARA - as low as reasonably achievable

32 Determine the risk level Low – No potential for airborne Moderate – May become airborne High – Likely to become airborne

33 Determine your risk level Nanotoolkit California Nanosafety Consortium of Higher Education

34 EH&S Approach Regulate all nanomaterial use through the Chemical Safety Committee Engineering Controls – Biosafety Cabinet, HEPA filter in specific fume hoods or self contained animal cages Administrative Controls Developed General Guidelines Use Safer Sharps On-going evaluation of literature and studies Exposure Assessment through EH&S Hazard Assessment through PeopleSoft PPE Lab coat Double gloving

35 Determine your risk level

36 Identify the controls needed Engineering Work Practices PPE

37 EH&S Approach Engineering Controls – exhausted hoods Administrative Controls Develop General Guidelines On-going evaluation of literature and studies Exposure Assessment through EH&S Hazard Assessment PPE Lab coat (disposable non fabric) Double gloving

38 Determine the Controls

39 Exhaust Hoods Highlight: All airborne free particulate nanomaterials should be manipulated in exhausted enclosures Preferably Class II Type B2 hoods, or VAV fume hoods

40 Exhaust Hoods Prefilters & HEPA filters will be serviced by vendors using bag in / bag out methods

41 Standard Operating Procedure Hazards Controls Accident and Spill Procedures Training Disposal

42 References

43 Conclusion An effort to create prudent practices in the absence of regulation Utilized existing and proven risk assessment systems Guidelines at your site


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