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Rebecca Flint Fascioliasis. Fascioliasis has world wide effects WHO designated extremely neglected disease Cases in 51 different countries 17 million.

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Presentation on theme: "Rebecca Flint Fascioliasis. Fascioliasis has world wide effects WHO designated extremely neglected disease Cases in 51 different countries 17 million."— Presentation transcript:

1 Rebecca Flint Fascioliasis

2 Fascioliasis has world wide effects WHO designated extremely neglected disease Cases in 51 different countries 17 million people affected

3 Oral-fecal transmission route Reservoir in livestock Watercress

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5 Disease manifests in the liver Acute phase – Flukes traveling to bile ducts – Nausea, vomiting, abdominal pain – Inflammation and bleeding – Liver tissue destruction Chronic phase – Producing eggs in bile ducts – Asymptomatic – Symptomatic

6 Diagnosis can be difficult Stool ova test ELISA or Western Blot Liver ultrasound

7 Few drugs have been used for treatment Bithionol - Less effective  Triclabendazole - 1983 - Effective against early stage parasites - Inhibits parasitic microtubule formation - Resistance in 1995

8 Cathepsin L proteases vaccine testing Fascilitate in tissue penetration, feeding, and immune system evasion Cathepsin L1 and L2 are the major fasciola proteases

9 FhSAP2 as a potential vaccine Potential to protect against subsequent fasciola hepatica metacercariae infections Fluke burden – Reduced 83.3% with cDNA-FhSAP2 – Reduced 60% with FhSAP2 protein

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11 Difficulty controlling Fasciola spread Individualized control plans Separation of livestock and farming Sanitation Cooked vegetables

12 References http://www.stanford.edu/class/humbio103/ParaSites2006/Fascioliasis/index.htm http://perutravelnews.info/Peru_geography.html http://www.dpd.cdc.gov/dpdx/html/fascioliasis.htm http://www.bvgh.org/Biopharmaceutical-Solutions/Global-Health-Primer/Diseases/cid/ViewDetails/ItemID/23.aspx Farid Z, Kamal M, Woody J (1988). Treatment of acute toxemic fascioliasis. Trans R Soc Trop Med Hyg, 82, 299. Dawes B. Some apparent effects of Bithionol (Actamer) on Fasciola hepatica. Nature. 209. 424–425. http://www.cdc.gov/parasites/fasciola.html http://www.sciencedirect.com/science/article/pii/S0020751903001711 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260556/ http://www.who.int/foodsafety/foodborne_disease/Fascioliasis.pdf http://www.who.int/bulletin/archives/77(4)340.pdf Neglected tropical diseases of the Middle East and North Africa: Review of their prevalence, distribution and opportunities for control http://ac.els-cdn.com/S001448000700010X/1-s2.0-S001448000700010X- main.pdf?_tid=82eb0beb26d3784c63b3fcd658db039e&acdnat=1333563684_9e8fd6d27e3ffb1fd0161e28213982e4 http://ac.els-cdn.com/S0020751903001711/1-s2.0-S0020751903001711- main.pdf?_tid=34f4d59141feb9d940a11d5c27187d3b&acdnat=1333563744_ba4fe537c7008eb34a64f709d662597b http://ac.els-cdn.com/S0304401709001642/1-s2.0-S0304401709001642- main.pdf?_tid=2428d0ca1d59c164e22da2549d1bead9&acdnat=1333563799_59532b3db68dd198cec5000e8417e16d http://ac.els-cdn.com/S1090023399903775/1-s2.0-S1090023399903775- main.pdf?_tid=241c67a32596ceb3ca75909744fc71c6&acdnat=1333563903_2ff3d34d9679ff21d2ec7451b180156a http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260556/


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