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Lectures on respiratory physiology Blood gas transport.

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Presentation on theme: "Lectures on respiratory physiology Blood gas transport."— Presentation transcript:

1 Lectures on respiratory physiology Blood gas transport

2 PO 2 = 0.21 x 760 mm Hg = 160 mm Hg As P B = 760 mm Hg CONCENTRATION AND PARTIAL PRESSURE [O 2 ] = 21 ml/dl FO 2 = 0.21 DRY AIR: 21% IS OXYGEN O 2 MOLECULES IN AIR

3 PO 2 = 0.21 x 713 mm Hg = 150 mm Hg P B = 760 mm Hg P DRY = 713 mm Hg 37 o C EFFECT OF WATER VAPOR P H 2 O = 47 mm Hg

4 WATER O 2 IN PHYSICAL SOLUTION AIR: PO 2 = 150 mm Hg 37 o C AIR AFTER EQUILIBRATION, WATER: PO 2 = 150 mm Hg AIR: [O 2 ] = 21 ml/dl WATER: [O 2 ] = 0.45 ml/dl SOLUBILITY = 0.45 / 150 = ml/(dl.mmHg) 37 o C

5 TRANSPORT OF O 2 IN SOLUTION DURING EXERCISE Solubility = ml/(dl. mmHg ) [O 2 ] = 0.3 ml/dl = 3 ml/liter PO 2 in arterial blood = 100 mm Hg Cardiac output = 30 liters/min Maximum O 2 available = 90 ml/min But O 2 requirement is 3000 ml/min

6 Structure of hemoglobin

7 Normal cells Sickle cells

8 Oxygen dissociation curve

9 ARTERIAL BLOOD VENOUS BLOOD P 50 27

10 TOTAL O 2 IN BLOOD IS THE SUM OF Hb-BOUND AND DISSOLVED O 2 TOTAL [O 2 ] = 1.39 x [Hb] x % SATURATION/ x PO 2

11 TOTAL O 2 IN ARTERIAL BLOOD (1.39 x 15 x 0.97) + (0.003 x 100) = 20.5 ml/dl

12 Effects of changing hemoglobin concentration

13 Shifting the O 2 dissociation curve

14 PARTIAL PRESSURE, mm Hg CO-Hb DISSOCIATION CURVE SATURATION, % CO O2O2

15 Effects of CO on the O 2 dissociation curve

16 Carbon dioxide is carried in the blood in three forms 1. Dissolved 2. As bicarbonate 3. As carbamino compounds

17 Solubility of Oxygen ml/(dl.mmHg) Solubility of Carbon Dioxide ml/(dl.mmHg)

18 Carriage of CO 2 in the blood

19 CO 2 + H 2 O H 2 CO 3 C.A. H 2 CO 3 H + + HCO 3 - Formation of bicarbonate

20 Hb.NH2 + CO2 Hb.NH.COOH Formation of carbamino compounds

21 Uptake of CO 2 in systemic capillaries

22 Carriage of CO 2 in the blood

23 CO 2 dissociation curves

24 Comparison of O 2 and CO 2 dissociation curves


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