Presentation on theme: "“DNA and Anti-Aging Management through Nature and Science”"— Presentation transcript:
“DNA and Anti-Aging Management through Nature and Science”
The information contained herein is furnished on a confidential basis to a limited number of sophisticated individuals for the purpose of providing certain information about LifeSpan International.
Innovator in the field of advanced proprietary DNA sciences and marketers of natural anti-aging solutions derived from patented extracts and processes AC-11® is a patented product designed to manage the effects of aging and cell damage by supporting the body's natural ability to repair and maintain its DNA. AC-11® is an extract from the bark of a specific Uncaria, a plant indigenous to the Amazon rainforest. Optigenex Inc. has developed a patented and proprietary process for isolating the plant's active compound, which is then converted into a water-soluble material that can remain in suspension or can be consumed in tablet or powder form as well as topically for cosmeceuticals, sun care, nutritional beverages and pet products. AC-11® has been shown to block the body's NF-kB pathway, the primary pathway for autoimmune diseases such as inflammatory bowel disease, arthritis, certain types of insulin dependency, lupus and other conditions – it’s a catalyst that sets DNA Repair in motion.
Patented extract from the bark of a specific Uncaria vine Patented extraction method that isolates the potent Carboxy Alkyl Esters which comprise the active ingredients in the bark No high molecular weight alkaloids associated with adverse reactions Sustainable Growth Project which is controlled by the Brazilian Environmental Institute (IBAMA) Work projects are conducted under the Floravida Institutes guidance
Patented natural DNA repair product Anti-inflammatory Boosts immune system function Highly water-soluble standardized product Protected, proprietary process eliminates 7 crude extracts known to cause side effects Validated in pre-clinical and clinical studies and published peer-reviewed articles Outstanding safety profile Measurable clinical endpoints
Stability data > 5 years LD50 > 8000 mg/kg – Our current recommended oral dosage is 350mg per day – Topical study doses range from 0.5% to 5.0% in solution No known toxicity Stability in activity & color as an ingredient in cosmetics Passes cosmetic micro-efficacy studies under USP challenge test method DSHEA registered Prop 65 Compliant
Production relationship with Centroflora Group, Brazil's premier natural ingredient producer State-of-the-art plant housing Optigenex-owned specialized AC-11® manufacturing equipment Patented Extraction Process U.S. Patent No. 6,039,949 Certified ISO 9002
AC-11® was developed and rigorously tested to ensure quality and effectiveness Comparison of a broad spectrum anti-aging nutritional supplement with and without the addition of a DNA repair enhancing AC-11® extract DNA repair enhancement of aqueous extracts of specific Uncaria in a human volunteer study Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae) Uncaria tomentosa inhibits TNFα production and scavenges free radicals: role in cytoprotection Anti-inflammatory actions of specific Uncaria: the role of NF-κB DNA repair enhancement of aqueous extracts of specific Uncaria in a human volunteer study Enhanced DNA repair, immune function and reduced toxicity of AC-11®, a novel aqueous extract from specific Uncaria Clinical studies abstracts Rainforest plants are responsible for 25%of the drugs used by Western medicine. 70% of the plants identified as having anti-cancer characteristics by the US National Cancer Institute are found only in the tropical rainforest. Well over 100 corporations and U.S. government agencies are studying rainforest plants for their medicinal capacities. However, the process of bringing a rainforest drug, or any pharmaceutical product, to market is long and costly.
AC-11® Bulk Cosmeceuticals Hair Care (In Development) Supplements Powders (near future) Sun Care launch scheduled for Spring of 2008 – Sun Care market valued at $1 billion – Will highlight AC-11® reversing effect on sun-damaged skin and a natural sunscreen.
$35 billion market, luxury brands growing 20+% annually – Anti-aging and cleansers show strongest growth – Simplicity of regimen, branding, and ingredients influence consumer use – Product efficacy and careful luxury distribution placement is key Anti-Aging Science
Supplements Sun Care- Anti-Aging Cosmeceutical Skin Car Cosmeceuticals are the fastest growing sector of the cosmetic industry. Their use has dramatically risen In recent years. The use of natural and especially botanical products is increasingly preferred by consumers The largest area of the Cosmeceutical market is skin care (60%) with special emphasis on the category of sun care and anti-aging. Figure 1. Source: Medical Insight Global Aesthetic Market Study, *All information on this page taken from data according to “Household and Personal Care TODAY” Figure 2. Cosmeceutical product demand. The figure was reproduced from:
U.S. Europe, Japan and Australia represent the largest markets From , annual growth rates averaged 20% per year Expected to continue to grow at approximately 24.3 % per year through 2007 DRIVING FACTORS Growing interest in anti-aging products (e.g. Propecia, Botox, etc.) by aging population Younger generation is keenly aware of aging signs and are interested in preventing aging process AC-11® DNA Repair Proprietary world wide potential market. *Source: Medical Insight Global Aesthetic Market Study, World population over 60 (million) Figure 3. Anti-aging product growth. The figure was reproduced from:
The world Cosmeceutical market is growing faster than any other cosmetic sectors. The world Cosmeceutical market today is about US$35 billion in sales. The largest markets for cosmeceuticals worldwide is the U.S. and Europe. LifeSpan distribution in all categories is targeted for the U.S. and International distribution. LifeSpan has worldwide connections to partner with the top distributors in the world for each country as well as duty-free.
The LifeSpan Anti-Aging Science with AC-11® contains some of the most effective anti-aging and potent anti-oxidant ingredients, which have been shown to reduce fine lines by 30%, and wrinkles by 60%, a new generation of cosmeceuticals. LifeSpan is the only Network Marketing Company in the world with AC-11® working at the source of aging itself. Before | After AC-11 Pentavitin Pepha-tight MDI Complex Matrixyl 3000 Sepilift DPHP
Scientifically proven to reverse the effects of sun damage. Before & After Ultra Violet Imaging
$2.4 billion Oral Supplement market Targeted consumers – 50+ consumers from upper incomes who attended college – Healthy lifestyle (healthy diet, non-smoker, normal weight, physically active) – Many health professionals Source: 2004 Nutrition Business Journal (NBJ)
A $25 billion market Aging boomers focus on health, quality of life and wellness Increased emphasis on disease prevention Complimentary and alternative treatments on the rise Growth in specialty supplements
“... the accumulation of random damage to the building blocks of life - especially to DNA, certain proteins, carbohydrates and lipids (fats) – that begins early in life and eventually exceeds the body’s self repair capabilities” Leonard Hayflick, PhD., UCSF S. Jay Olshanky, PhD., UIC Bruce Carnes, PhD., UIC Scientific American, June 2002; 286(6):92-95
Mutations Replication errors Persistent DNA damage Genomic instability DNA DAMAGE REPLICATION AGING CANCER National Institute of Health
Oxidative Stress Damage to DNA (nucleus & mitochondria) Poor DNA Repair Aging and Aging Conditions
YOUR ENVIRONMENT (Poor diet, stress, pollution, smoking, exercise, sun exposure generate free radicals) OXIDATIVE STRESS GOOD GENE REPAIR equals Antiaging GENE DAMAGE equals Aging ALTERED GENE EXPRESSION Hobbled Proteins (Glycation) Wrong soup mix (Mitochonria function) Misfiring genetic switches (Methylation and acetylation) Immune glitches (Inflammation) Faulty cell communication (Hormone imbalance)
DNA DAMAGE Mutagenic Diseases e.g. Cancer Mutagenic Diseases e.g. Cancer Chronic Disease e.g. Inflammation Chronic Disease e.g. Inflammation Two possible health consequences The major cause of human disease has been identified as DNA damage by reactive oxygen species. This has been reviewed as a contributing factor for the origin and progression of a number of conditions including aging, autoimmunity, HIV infection and cancer.
STEP 1. DNA damage detected. Enzymes uncoil and unzip DNA. (NFk-B inhibition works here also by stopping free radicals that damage DNA) STEP 2. Uncoiled structure gives access to repair enzymes. STEP 3. Damaged or misplaced nucleotides are cut out by DNA repair enzymes. (Active genes are repaired first, then less active genes) STEP 4. New segments are moved into place and the seams are sealed by other enzymes. #4#2#3#1
DNA repair of damage No disease Mutagenic and toxic disease IncompleteComplete Gene Deficiency Biochemical Inhibition
AC-11 Present Natural DNA Repair AC-11 Absent Natural DNA Repair
Articles by Dr. Noah Scheinfeld, Optigenex Chief Medical Consultant Botanical extract protects against UV Study results intriguing, researchers look to further applications Jul 1, 2006 Journal of Drugs in Dermatology AC-11 and Dimercine Two DNA Enhancers February 2006 Volume 5 Issue 2 Skin and Aging DNA Repair Adjuvants February 2006
Patents Include: U.S. patent no. 6,039,949 “Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria”. This patent is directed to a method for preparing the extract and for its administration generally. U.S. patent no. 6,238,675 B1 “Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria for Enhancing Immune, Anti-inflammatory and Anti-tumor Processes of Warm Blooded Animals”. This patent is directed to composition of the extract described in the ‘949 patent and its pharmaceutical use for the enhancement of the immune, anti-inflammatory, anti-tumor processes. U.S. patent no. 6,361,805 B2 “Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria for Enhancing Immune, Anti-inflammatory and Anti-tumor and DNA Repair Processes of Warm Blooded Animals”. This patent extends coverage to DNA repair. U.S. patent no. 6,974,784 B2 “Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-inflammatory and Anti-tumor and DNA Repair Processes of Warm Blooded Animals”. The patent is directed to administer the isolated purified active ingredient of the composition claimed in the ‘675 patent, quinic acid alkyl ester.
Pending Applications: “Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals “Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals “Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals. Foreign Patents: PCT Application WO 2003/ “Isolation, Purification and Structural Identification of a Bioactive Component of a Water Soluble Extract of a Botanical Species for Enhancing Immune, Anti-inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals”. This application covers the water soluble extract.
Nick Mangeris (C.E.O., Sales & Marketing Director) Darrel Davis, B.A. (Executive V.P.) George Berry (C.O.O. & Bio-Chemist) Kim Hubartt (Manager, IT & Customer Support) Bruce Wood (Vice President, Sales & Marketing) Dr. Neil Solomon, M.D., Ph.D. (Medical Advisor & Science Director) Anthony Worth, B.S., C.N., IAACN (Technical Director & Scientific Advisor) Serdar Abaci (Webmaster)