Presentation on theme: "Chapter 32 Disorders of Endocrine Control of Growth and Metabolism"— Presentation transcript:
1 Chapter 32 Disorders of Endocrine Control of Growth and Metabolism
2 Hypothalamus- Pituitary Axis Releasing hormones from hypothalamus tell the pituitary what to release into the bloodTrophic hormones from the pituitary tell specific peripheral glands to grow and produce their hormones
3 Hormone DisordersTertiary: abnormality in stimulation from the hypothalamusSecondary: abnormality in stimulation from the pituitaryAuthor: Add text?Primary: abnormality in the gland
11 Question Tell whether the following statement is true or false: GH deficiency may result in dwarfism.
12 AnswerTrueLaron-type dwarfism is caused by a genetic inability to produce normal amounts of GH.
13 The Hypothalamus Controls Gonadal Hormone Release Excessive GnRH secretion can be stimulated by:Hypothalamus tumorsPituitary tumorsGiving high levels of GnRH causes the pituitary to become less responsive and reduces the effects of abnormal GnRH secretionGnRHstimulatesanterior pituitaryFSHLHproduction of gametesand gonadal hormones
14 Thyroid Control Thyroid releases T3 and T4 Both are carried by binding proteinsT3 stimulates metabolismT4 is inactive until converted into T3 in the tissuesBoth exert negative feedback on the hypothalamus
15 Thyroid Insufficiency Due to Lack of I- T3 and T4 are not madeThere is no negative feedback to the hypothalamusTRH and TSH continue to be madeIf it is able, the thyroid will grow in response to the TSH
17 Question Tell whether the following statement is true or false: Simple goiter is caused by increased production of thyroid hormone.
18 AnswerFalseSimple goiter is the result of iodine (I) insufficiency. Since I is necessary in order to produce thyroid hormone, a deficiency results in low serum levels of T3/T4. This causes TSH to stimulate the thyroid gland to make more hormone (which it cannot do because it needs I). The cells of the thyroid gland hypertrophy in an effort to function (make thyroid hormone).
24 Scenario Three men have adrenal problems… One has hypoaldosteronism, one has an inability to make cortisol, and one has an inability to make testosterone.QuestionWhich of them is most likely to develop:Hypotension?High CRH levels?Hypoglycemia?Hypervirilization?Decreased libido?Hyperkalemia?
25 Scenario Two women have benign pituitary tumors… One woman has lost weight and complains of being hot all the time; she presents as thin and nervous, with tachycardia and exophthalmosThe second woman has gained weight in her abdomen and presents with a round face and thin arms and legs with stretch marks; she says that at her last checkup her doctor told her she was pre- diabeticQuestionWhat hormones are being secreted by the pituitary tumors in these patients? Why?