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Thyroid gland firstname.lastname@example.org
Specifics Iodine is rare Ubiquitary receptors Highly potent action Very common disorders – 5% women – 0,5% men
T3, T4 synthesis
T3, T4 metabolism
Iodine intake 150 ug – daily intake of iodine 125 ug – taken up by the thyroid gland Iodine in the soil – region dependent Iodide supplementation of salt
Thyroid hormones In the thyroid gland – 90% T4 – 10% T3 TBG, transthyretin In the periphery – 80% T3 – 10% T4 – 10% rT3
Receptors Membrane bound receptors
Action Increase of number and size of mitochondria Synthesis of respiratory chain enzymes Na+ K+ ATPase Uncloupling proteins Increase in resting metabolic activity
Hyperthyroidism Symptoms Common Anxiety and irritability (~ >90%)Tachycardia (~ 100%) Palpitations (~ 90%)Tremor (~ 95%) Increased perspiration and heat intolerance (~ 90%) Goiter (~ 100%) Fatigability (~ 80%)Warm moist skin (~ 95%) Weakness (~ 70%) Increased appetite and weight loss (~ 85%) Less common Dyspnoea (~ 65%)Atrial fibrillation (~ 10%) Increased bowel frequency (~ 30%) Onycholysis (~ <5%) Anorexia (~ 10%)‘Liver palms’ (~ 5%) Weight gain (~ <5%)Heart failure (~ 5%) Oligomenorrhea (~ 25%) Rare Pruritus (~ <1%) Periodic paralysis (~ <1%)
Hyperthyroidism – Grave’s disease
Grave’s disease Grave’s Basedow trias – Goiter – Exophtalmus – Hyperthyroidism Autoimmune disease – Anti-TSH receptor
Hypothyroidism SymptomsSigns Common Fatigue (~ 90%)Dry, scaly skin (~ 90%) Cold intolerance (~ 80%) Coarse, brittle thinning hair (~ 60%) Depression (~ 70%)Bradycardia (~ 40%) Poor concentration (~ 65%)Hair loss or dryness (~ 70%) Musculoskeletal aches and pains (~ 25%) Anemia Carpal tunnel syndrome (~ 15%) Puffy eyes (~ 90%) Less common Constipation (~ 50%)Edema (~ 30%) Hoarse voice (~ 40%)Cerebellar signs* Menorrhagia (~ 30%)Deafness* Psychiatric*
Primary – Thyroid gland – Hashimoto’s disease Autoimmune thyroid destruction – Creteinism Neonatal screening Secondary – Pituitary gland
MLAB 2401: Clinical Chemistry Keri Brophy-Martinez Thyroid Gland.
Hyperthyroidism- is the result of a over active thyroid. It happens when immune system produces antibodies that attack the thyroid, make it produce.
Thyroid disorders Dr. Aishah Ekhzaimy December 2014.
Hyperthyroidism. TRH –Thyrotropin-releasing hormone Produced by Hypothalamus Release is pulsatile Downregulated by T 3 Travels through portal.
Thyroid disorders Dr. Aishah Ekhzaimy February 2016.
Thyroid Gland DR SYED SHAHID HABIB MBBS FCPS DSDM.
Frank P. Dawry Therapy of Hyperthyroid Thyroid Disease with Iodine-131.
Endocrine Disorders. System Review Simply put, endocrinology is the study of endocrine glands. Endocrine glands are a group of glands in the body which.
Endocrine Block 1 Lecture Dr. Usman Ghani Biochemistry of Thyroid Hormones and Thermogenesis.
PULSE October 28, 2009 Pennsylvania State College of Medicine Nicolai Wohns.
Thyroid Disease in Pregnancy Perinatal Conference April 14, 2006.
BIOCHEMISTRY OF THYROID HORMONES ENDOCRINE SYSTEM, 2009 NABIL BASHIR.
The thyroid (Greek thyreos, shield, plus eidos, form) consists of two lobes connected by isthmus Anterior to the trachea between the cricoid cartilage.
ENDOCRINOLOGY Ⅱ Pituitary Gland. Thyroid gland The thyroid hormones Synthesis and secretion: epithelioid cells Storage: in colloid,a large glycoprotein.
THYROID GLAND. Hormones: - 3,5,3',5‘ tetraiodothyronine (thyroxine, T 4 ) - 3,5,3' triiodothyronine (T 3 ) - 3,3',5‘ reverse triiodothyronine (RT 3 )
Endo 1.08 The thyroid gland Gross anatomy and histology of the thyroid gland Thyroid hormone synthesis Thyroid hormone secretion, peripheral conversion.
4. Mr. Holdt brings his wife to the clinic, concerned about her nervousness, heart palpitations, and excessive sweating. Tests show hypergycemia and hypertension.
Graves Disease Taylor Dobbs. Graves Disease The most common form of hyperthyroidism When the immune system mistakenly attacks your thyroid gland and causes.
Chapter 76: Thyroid Metabolic Hormones Guyton and Hall, Textbook of Medical Physiology, 12 edition.
Secretes three hormones essential for proper regulation of metabolism ◦ Thyroxine (T 4 ) ◦ Triiodothyronine (T 3 ) ◦ Calcitonin Located near the parathyroid.
Graves’ and Thyroid Disease: The Journey CHASE LAY MD ENT – OCULOPLASTICS – SKULL BASE Cupertino, CA.
The Endocrine System Chapter 18. Lesson 1. Endocrine Glands Ductless-or tubeless- organs or group of cells that secrete hormones directly into the bloodstream.
MONTANA WRIGLEY & SIERRA RYALS Graves Disease. What is Graves’ Disease? An immune system disorder that results in the production of thyroid hormones Causes.
Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. CHAPTER 30 Thyroid and Antithyroid Drugs.
Thyroid gland One of largest pure endocrine glands in the body ( 20gms). Its size depends on: 1. age … age size. 2. sex … female > male. 3.
Andy Herrera Francisco Diaz Jorge De Pena. What is Thyroxide? Thyroxine (T4) is one of the hormones produced by the thyroid gland that helps regulate.
Thyroid Disorders. Endocrine Glands Collection of glands that secrete hormones directly into the bloodstream. Adrenal glands, parathyroid glands, pancreas,
Thyroid Hormones. Thyroid Hormone Action Thyroid gland is the largest endocrine gland in the body Thyroid hormones facilitate normal growth and maturation.
Endocrine Block 1 Lecture Reem Sallam, MD, MSc, PhD Thyroid Hormones and Thermogenesis.
The Endocrine System. Consists of: –Glands: Tissue that secretes hormones –Hormones: Chemicals that are produced in ductless glands in one area and are.
By: Mark Torres Human Anatomy and Physiology II TR3:15-6:00.
Physiological roles Influence on many aspects of body function –Direct action –Indirect action Early growth and development Deficiency –Abnormalities Growth.
THYROID PATHOPHYSIOLOGY. Hypothalamic-Pituitary-Thyroid Axis This is a negative feedback system. TRH produced in the paraventricular nuclei of the hypothalamus.
METABOLISM Thyroid Gland is located in front of the trachea. It produces hormones: Thyroxine (T4) Triiodothyronine (T3) T4 and T3 regulate body metabolism.
MORNING REPORT Johana Rodriguez. ThyrotoxicosisThyrotoxicosis.
HYPERTHYROIDISM A presentation by Mohd Ruhaizie bin Riyadzi, one of the hyperthyroidism patient.
Diagnostic Tests for Thyroid Disease Diagnostic Tests for Thyroid Disease Problems with energy, mental capacity, and weight may be due to thyroid disease.
Mosby items and derived items © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. CHAPTER 31 Thyroid and Antithyroid Drugs.
THYROID GLAND Chloe Benner and Michelle Olson. LOCATION Situated in the anterior part of the neck “Adams’ apple” Originates in the back of the tongue.
Goiter. Thyroid Gland Thyroid Hormones: Functions PERMISSIVE ACTIONS –Growth and development –Reproduction DIRECT EFFECTS –Metabolic/thermogenic.
Hypothyroidism By Megan, Mackenzie and James. Symptoms of Hyperthyroidism Appetite change (decrease or increase) Difficulty sleeping (insomnia)
Thyroid in Health and Disease Richard B. Horenstein, MD Assistant Professor Department of Medicine Division of Endocrinology Diabetes & Nutrition.
Hyperthyroidism 于明香 Endocrinology Department Zhongshan Hospital, Fudan University Endocrinology Department Zhongshan Hospital, Fudan University.
Chapter 18 Lesson 1 Warm Up What do you think the function of the Endocrine Glands are?
The Trace Minerals Copyright 2005 Wadsworth Group, a division of Thomson Learning.
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THYROID Peer Support What hormones are secreted by the thyroid gland? T 4 (thyroxine) T 3 (tri-iodothyronine) These are referred to as the thyroid.
Definitions: 1. Metabolism – A term which refers to all the chemical reactions of a cell. 2. Enzymes – A protein catalyst. (Speeds up certain reactions)
CNA 2 OSBN Curriculum yer/movie.php?movie=http://ss1.medcomrn. com/flv/78723r_sec01_300k.flv&title=&dete ctflash=false&detectflash=false.
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