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Published byBraydon Tranter
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Specifics Iodine is rare Ubiquitary receptors Highly potent action Very common disorders – 5% women – 0,5% men
T3, T4 synthesis
T3, T4 metabolism
Iodine intake 150 ug – daily intake of iodine 125 ug – taken up by the thyroid gland Iodine in the soil – region dependent Iodide supplementation of salt
Thyroid hormones In the thyroid gland – 90% T4 – 10% T3 TBG, transthyretin In the periphery – 80% T3 – 10% T4 – 10% rT3
Receptors Membrane bound receptors
Action Increase of number and size of mitochondria Synthesis of respiratory chain enzymes Na+ K+ ATPase Uncloupling proteins Increase in resting metabolic activity
Hyperthyroidism Symptoms Common Anxiety and irritability (~ >90%)Tachycardia (~ 100%) Palpitations (~ 90%)Tremor (~ 95%) Increased perspiration and heat intolerance (~ 90%) Goiter (~ 100%) Fatigability (~ 80%)Warm moist skin (~ 95%) Weakness (~ 70%) Increased appetite and weight loss (~ 85%) Less common Dyspnoea (~ 65%)Atrial fibrillation (~ 10%) Increased bowel frequency (~ 30%) Onycholysis (~ <5%) Anorexia (~ 10%)‘Liver palms’ (~ 5%) Weight gain (~ <5%)Heart failure (~ 5%) Oligomenorrhea (~ 25%) Rare Pruritus (~ <1%) Periodic paralysis (~ <1%)
Hyperthyroidism – Grave’s disease
Grave’s disease Grave’s Basedow trias – Goiter – Exophtalmus – Hyperthyroidism Autoimmune disease – Anti-TSH receptor
Hypothyroidism SymptomsSigns Common Fatigue (~ 90%)Dry, scaly skin (~ 90%) Cold intolerance (~ 80%) Coarse, brittle thinning hair (~ 60%) Depression (~ 70%)Bradycardia (~ 40%) Poor concentration (~ 65%)Hair loss or dryness (~ 70%) Musculoskeletal aches and pains (~ 25%) Anemia Carpal tunnel syndrome (~ 15%) Puffy eyes (~ 90%) Less common Constipation (~ 50%)Edema (~ 30%) Hoarse voice (~ 40%)Cerebellar signs* Menorrhagia (~ 30%)Deafness* Psychiatric*
Primary – Thyroid gland – Hashimoto’s disease Autoimmune thyroid destruction – Creteinism Neonatal screening Secondary – Pituitary gland
1Elsevier items and derived items © 2007 by Saunders, an imprint of Elsevier, Inc. Chapter 45 Thyroid and Parathyroid Disorders.
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Minerals: Major and Trace. Major Minerals sodium sodium chloride chloride potassium potassium calcium calcium phosphorus phosphorus magnesium magnesium.
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© 2013 Pearson Education, Inc. Thyroid Gland Two lateral lobes connected by median mass called isthmus Composed of follicles that produce glycoprotein.
Received his master degree in 1994 at Shanghai Second Medical University; Took his doctors degree on Endocrinology at shanghai Jiaotong University school.
Endocrine System 2011 Summary. Body conditions are controlled by which systems? 1.The nervous system 2.The endocrine system.
THYROID DISORDERS Sarah Chaudhry and Eugenia Gisin 10/21/13.
DISTURBANCES OF THE ENDOCRINE SYSTEM THE ADRENAL GLAND.
Thyroid Health. The Thyroid Gland is a small gland, normally weighing less than one ounce, located in the front of the neck. It is made up of two halves,
Daniel Orr The Highs and Lows Thyroid Problems in the ICU.
Terminology Gland: ghiandola Disease: malattia, disfunzione Thyroid gland: ghiandola tiroidea To affect: colpire To harm: compromettere, danneggiare, arrecare.
Chapter 11 Care of the Patient with an Endocrine Disorder Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc.
Endocrine System Diseases Introduction to Human Diseases: Chapter 14.
A ppt on THYROID HORMONESAND THYROID INHIBITORS By Dr.Nanita Agrawal, Dr. Prashant,MD Pharmacology4students.com 1dr prashant's.
PowerPoint ® Lecture Slides prepared by Janice Meeking, Mount Royal College C H A P T E R Copyright © 2010 Pearson Education, Inc. 16 The Endocrine System:
1Elsevier items and derived items © 2007 by Saunders, an imprint of Elsevier, Inc. Chapter 14 Fluids and Electrolytes.
การให้ยาระงับความรู้สึก ในผู้ป่วยโรคเบาหวาน และโรคต่อมไทรอยด์ พญ. รัตนาภรณ์ บุริมสิทธิชัย ภาควิชาวิสัญญีวิทยา โรงพยาบาลจุฬาลงกรณ์
Aim: How do cells of the body communicate? HW 1 Read pages Fill in the handout.
Chapter 1 Organization of the Human Body- Life-Span Changes.
1 Chapter 21 Water, Electrolyte, and Acid-Base Balance D- water and electrolyte balance Anatomy and Physiology.
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Human Anatomy & Physiology, Sixth Edition Elaine N. Marieb PowerPoint ® Lecture.
Richard Allan Bettis, Fourth-Year Pharm.D. Candidate Preceptor: Dr. Ali Rahimi University of Georgia College of Pharmacy Geriatric Malnutrition.
By: Mike McKenna Lou Maselli Brendan Quinn. Cushing’s Syndrome Hyperthyroidism Glucagonoma Multiple Endocrine Neoplasia (MEN) Hypopituitarism.
TIME TO ACT Type 2 diabetes, the metabolic syndrome and cardiovascular disease in Europe.
Copyright © 2012 Pearson Education, Inc. 9 C H A P T E R Nutrients Involved in Bone Health and In Depth.
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