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A) Normal learning b) Memantine BAX BAD BCL2 CASP3 pCASP9 Cytosolic BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9 c) Normal learning + Memantine.

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Presentation on theme: "A) Normal learning b) Memantine BAX BAD BCL2 CASP3 pCASP9 Cytosolic BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9 c) Normal learning + Memantine."— Presentation transcript:

1 a) Normal learning b) Memantine BAX BAD BCL2 CASP3 pCASP9 Cytosolic BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9 c) Normal learning + Memantine Supplementary Figure S1. Hippocampus, Apoptosis related proteins BAX BAD BCL2 CASP3 pCASP9 Nuclear BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9

2 SOD1 ITSN1 DYRK1A GAD2 GFAP nNOS SHH SNCA TH Ubiquitin SOD1 ITSN1 DYRK1A GAD2GFAPnNOS SHH SNCA TH Ubiquitin SOD1 ITSN1 DYRK1A GAD2GFAPnNOS SHH SNCA TH Ubiquitin SOD1 ITSN1 GAD2 GFAP nNOS SHH SNCA TH Ubiquitin DYRK1A SOD1 ITSN1 GAD2 GFAP nNOS SHH SNCA TH Ubiquitin SOD1 ITSN1 GAD2 GFAP nNOS SHH SNCA TH Ubiquitin DYRK1A a) Normal learning Nuclear b) Memantine Cytosolic c) Normal learning + Memantine Supplementary Figure S2. Hippocampus, Miscellaneous proteins

3 pGSK3B_Tyr216 BRAF pBRAF MEK pMEK ERK pERK RSK pRSK ELK CREB pCREB CAMKII pCAMKII PKCA pPKCA/B pPKCG JNK pJNK P38 pMTOR P70S6 pP70S6 S6 RAPTOR AMPKA AKT pAKT pS6 pEIF4B MTOR GSK3B pGSK3B_S9 pELK pGSK3B_Tyr216 BRAF pBRAF MEK pMEK ERK pERK RSK pRSK ELK CREB pCREB CAMKII pCAMKII PKCA pPKCA/B pPKCG JNK pJNK P38 pMTOR P70S6 pP70S6 S6 RAPTOR AMPKA AKT pAKT pS6 pEIF4B MTOR GSK3B pGSK3B_S9 pELK pGSK3B_Tyr216 BRAF pBRAF MEK pMEK ERK pERK RSK pRSK ELK CREB pCREB CAMKII pCAMKII PKCA pPKCA/B pPKCG JNK pJNK P38 pMTOR P70S6 pP70S6 S6 RAPTOR AMPKA AKT pAKT pS6 pEIF4B MTOR GSK3B pGSK3B_S9 pELK a) Normal learning b) Memantine c) Normal learning + Memantine MAPK MTOR Supplementary Figure S3. Cortex, Cytosol-MAPK and MTOR

4 APP RCAN1 CTNNB1 CDK5 P35/25 ERBB4 Tau IL1B PP2A FYN pSRC CaNA Cytosol Nuclear a) Normal learning b) Memantine c) Normal learning + Memantine APP RCAN1 CTNNB1 CDK5 P35/25 ERBB4 Tau IL1B PP2A FYN pSRCCaNA Supplementary Figure S4. Cortex, AD related proteins APP RCAN1 CTNNB1 CDK5 P35/25 ERBB4 Tau IL1B PP2A FYN pSRC CaNA APP RCAN1 CTNNB1 CDK5 FYN CaNA ERBB4 APP RCAN1 CTNNB1 CDK5 FYN CaNA ERBB4 APP RCAN1 CTNNB1 CDK5 FYN CaNA ERBB4 Membrane APP CTNNB1 CDK5 P35/25 ERBB4 Tau IL1B PP2A FYN pSRCCaNA RCAN1 APP CTNNB1 CDK5 P35/25 ERBB4 Tau IL1B PP2A FYN pSRC CaNA RCAN1 APP CTNNB1 CDK5 P35/25 ERBB4 Tau IL1B PP2A FYN pSRC CaNA RCAN1

5 GLUR3 NR2A pNR2A NR2B pNR2B pNR1 GLUR4 pGLUR2 TRKA BDNF NUMB pNUMB PSD95 NR1 CAMKII pCAMKII TIAM1 Supplementary Figure S5. Cortex, Cytosol-NMDA receptor subunits and related proteins b) Memantine GLUR3 NR2A pNR2A NR2B pNR2B pNR1 GLUR4 pGLUR2 TRKABDNF NUMB pNUMB PSD95 NR1 CAMKII pCAMKII TIAM1 GLUR3 NR2A pNR2A NR2B pNR2B pNR1 GLUR4 pGLUR2 TRKA BDNF NUMB pNUMB PSD95 NR1 CAMKII pCAMKII TIAM1 a) Normal learning c) Normal learning + Memantine

6 CFOS pCFOS ARC EGR1 H3 (AcK9) H3 (AcK18) H3 (MeK4) CFOS pCFOS ARC EGR1 H3 (AcK9) H3 (AcK18) H3 (MeK4) CFOS pCFOS ARC EGR1 H3 (AcK9) H3 (AcK18) H3 (MeK4) a) Normal learning b) Memantine c) Normal learning + Memantine Supplementary Figure S6. Cortex, Nuclear-IEgs and Histone modifications proteins

7 BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9 a) Normal learning Nuclear b) Memantine Cytosolic c) Normal learning + Memantine Supplementary Figure S7, Cortex, Apoptosis related proteins

8 SOD1 ITSN1 GAD2 GFAP nNOS SHH SNCA TH Ubiquitin DYRK1A SOD1 ITSN1 GAD2GFAP nNOS SHH SNCA TH Ubiquitin DYRK1A SOD1 ITSN1 GAD2 GFAP nNOS SHH SNCA TH Ubiquitin DYRK1A SOD1 ITSN1 GAD2 GFAP nNOS SHH SNCA TH Ubiquitin DYRK1A SOD1 ITSN1 GAD2 GFAP nNOS SHH SNCA TH Ubiquitin DYRK1A SOD1 ITSN1 GAD2 GFAP nNOS SHH SNCA TH Ubiquitin DYRK1A a) Normal learning Nuclear b) Memantine Cytosolic c) Normal learning + Memantine Supplementary Figure S8. Cortex, Miscellaneous proteins


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